A Prospective Study of Causes of Illness and Death in Preterm Infants in Ethiopia: The SIP Study Protocol
Abstract Background With nearly 15 million annual preterm births globally, preterm birth is the most common cause of neonatal death. Forty to 60 % of neonatal deaths are directly or indirectly associated with preterm mortality. As countries aim to meet the Sustainable Development Goals to reduce neo...
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | Reproductive Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12978-018-0555-y |
| _version_ | 1818614566055051264 |
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| author | Lulu M. Muhe Elizabeth M. McClure Amha Mekasha Bogale Worku Alemayehu Worku Asrat Dimtse Goitom Gebreyesus Zemene Tigabu Mahlet Abayneh Netsanet Workneh Beza Eshetu Abayneh Girma Mesfin Asefa Ramon Portales Mahlet Arayaselassie Yirgu Gebrehiwot Tiruzer Bekele Mesele Bezabih Gesit Metaferia Mulatu Gashaw Bewketu Abebe Alemu Geleta Abdulkadir Shehibo Yohanes Hailu Hailu Berta Addisu Alemu Tigist Desta Rahel Hailu Janna Patterson Assaye K Nigussie Robert L. Goldenberg |
| author_facet | Lulu M. Muhe Elizabeth M. McClure Amha Mekasha Bogale Worku Alemayehu Worku Asrat Dimtse Goitom Gebreyesus Zemene Tigabu Mahlet Abayneh Netsanet Workneh Beza Eshetu Abayneh Girma Mesfin Asefa Ramon Portales Mahlet Arayaselassie Yirgu Gebrehiwot Tiruzer Bekele Mesele Bezabih Gesit Metaferia Mulatu Gashaw Bewketu Abebe Alemu Geleta Abdulkadir Shehibo Yohanes Hailu Hailu Berta Addisu Alemu Tigist Desta Rahel Hailu Janna Patterson Assaye K Nigussie Robert L. Goldenberg |
| author_sort | Lulu M. Muhe |
| collection | DOAJ |
| description | Abstract Background With nearly 15 million annual preterm births globally, preterm birth is the most common cause of neonatal death. Forty to 60 % of neonatal deaths are directly or indirectly associated with preterm mortality. As countries aim to meet the Sustainable Development Goals to reduce neonatal mortality, significant reductions in preterm mortality are needed. This study aims to identify the common causes of preterm illness and their contribution to preterm mortality in low-resource settings. This article will describe the methods used to undertake the study. Methods This is a prospective, multi-centre, descriptive clinical study. Socio-demographic, obstetric, and maternal factors, and clinical and laboratory findings will be documented. The major causes of preterm mortality will be identified using clinical, laboratory, imaging, and autopsy methods and use the national Ethiopian guidelines on management of preterm infants including required investigations to reach final diagnoses. The study will document the clinical and management protocols followed in these settings. The approach consists of clinical examinations and monitoring, laboratory investigations, and determination of primary and contributory causes of mortality through both clinical means and by post-mortem examinations. An independent panel of experts will validate the primary and contributory causes of mortality. To obtain the estimated sample size of 5000 preterm births, the study will be undertaken in five hospitals in three regions of Ethiopia, which are geographically distributed across the country. All preterm infants who are either born or transferred to these hospitals will be eligible for the study. Three methods (last menstrual period, physical examination using the New Ballard Score, and ultrasound) will be used to determine gestational age. All clinical procedures will be conducted per hospital protocol and informed consent will be taken from parents or caretakers prior to their participation in the study as well as for autopsy if the infant dies. Discussion This study will determine the major causes of death and illness among hospitalized preterm infants in a low-resource setting. The result will inform policy makers and implementers of areas that can be prioritized in order to contribute to a significant reduction in neonatal mortality. |
| first_indexed | 2024-12-16T16:20:03Z |
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| institution | Directory Open Access Journal |
| issn | 1742-4755 |
| language | English |
| last_indexed | 2024-12-16T16:20:03Z |
| publishDate | 2018-06-01 |
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| series | Reproductive Health |
| spelling | doaj.art-005a3105690c4ad4a5ec0f8c96ee92c12022-12-21T22:24:55ZengBMCReproductive Health1742-47552018-06-011511910.1186/s12978-018-0555-yA Prospective Study of Causes of Illness and Death in Preterm Infants in Ethiopia: The SIP Study ProtocolLulu M. Muhe0Elizabeth M. McClure1Amha Mekasha2Bogale Worku3Alemayehu Worku4Asrat Dimtse5Goitom Gebreyesus6Zemene Tigabu7Mahlet Abayneh8Netsanet Workneh9Beza Eshetu10Abayneh Girma11Mesfin Asefa12Ramon Portales13Mahlet Arayaselassie14Yirgu Gebrehiwot15Tiruzer Bekele16Mesele Bezabih17Gesit Metaferia18Mulatu Gashaw19Bewketu Abebe20Alemu Geleta21Abdulkadir Shehibo22Yohanes Hailu23Hailu Berta24Addisu Alemu25Tigist Desta26Rahel Hailu27Janna Patterson28Assaye K Nigussie29Robert L. Goldenberg30College of Medical Sciences, Addis Ababa UniversityRTI InternationalCollege of Medical Sciences, Addis Ababa UniversityEthiopian Pediatric SocietyCollege of Medical Sciences, Addis Ababa UniversityCollege of Medical Sciences, Addis Ababa UniversityCollege of Medical Sciences, Addis Ababa UniversityUniversity of GondarSt Paul’s Hospital Millennium Medical CollegeJimma UniversityJimma UniversityUniversity of GondarSt Paul’s Hospital Millennium Medical CollegeSt Paul’s Hospital Millennium Medical CollegeCollege of Medical Sciences, Addis Ababa UniversityCollege of Medical Sciences, Addis Ababa UniversityUniversity of GondarJimma UniversitySt Paul’s Hospital Millennium Medical CollegeJimma UniversityUniversity of GondarJimma UniversityUniversity of GondarUniversity of GondarCollege of Medical Sciences, Addis Ababa UniversityJimma UniversityCollege of Medical Sciences, Addis Ababa UniversityCollege of Medical Sciences, Addis Ababa UniversityAmerican Academy of PediatricsBill and Melinda Gates FoundationColumbia UniversityAbstract Background With nearly 15 million annual preterm births globally, preterm birth is the most common cause of neonatal death. Forty to 60 % of neonatal deaths are directly or indirectly associated with preterm mortality. As countries aim to meet the Sustainable Development Goals to reduce neonatal mortality, significant reductions in preterm mortality are needed. This study aims to identify the common causes of preterm illness and their contribution to preterm mortality in low-resource settings. This article will describe the methods used to undertake the study. Methods This is a prospective, multi-centre, descriptive clinical study. Socio-demographic, obstetric, and maternal factors, and clinical and laboratory findings will be documented. The major causes of preterm mortality will be identified using clinical, laboratory, imaging, and autopsy methods and use the national Ethiopian guidelines on management of preterm infants including required investigations to reach final diagnoses. The study will document the clinical and management protocols followed in these settings. The approach consists of clinical examinations and monitoring, laboratory investigations, and determination of primary and contributory causes of mortality through both clinical means and by post-mortem examinations. An independent panel of experts will validate the primary and contributory causes of mortality. To obtain the estimated sample size of 5000 preterm births, the study will be undertaken in five hospitals in three regions of Ethiopia, which are geographically distributed across the country. All preterm infants who are either born or transferred to these hospitals will be eligible for the study. Three methods (last menstrual period, physical examination using the New Ballard Score, and ultrasound) will be used to determine gestational age. All clinical procedures will be conducted per hospital protocol and informed consent will be taken from parents or caretakers prior to their participation in the study as well as for autopsy if the infant dies. Discussion This study will determine the major causes of death and illness among hospitalized preterm infants in a low-resource setting. The result will inform policy makers and implementers of areas that can be prioritized in order to contribute to a significant reduction in neonatal mortality.http://link.springer.com/article/10.1186/s12978-018-0555-yNeonatal mortalityPreterm birthLow-middle income countriesCause of death |
| spellingShingle | Lulu M. Muhe Elizabeth M. McClure Amha Mekasha Bogale Worku Alemayehu Worku Asrat Dimtse Goitom Gebreyesus Zemene Tigabu Mahlet Abayneh Netsanet Workneh Beza Eshetu Abayneh Girma Mesfin Asefa Ramon Portales Mahlet Arayaselassie Yirgu Gebrehiwot Tiruzer Bekele Mesele Bezabih Gesit Metaferia Mulatu Gashaw Bewketu Abebe Alemu Geleta Abdulkadir Shehibo Yohanes Hailu Hailu Berta Addisu Alemu Tigist Desta Rahel Hailu Janna Patterson Assaye K Nigussie Robert L. Goldenberg A Prospective Study of Causes of Illness and Death in Preterm Infants in Ethiopia: The SIP Study Protocol Reproductive Health Neonatal mortality Preterm birth Low-middle income countries Cause of death |
| title | A Prospective Study of Causes of Illness and Death in Preterm Infants in Ethiopia: The SIP Study Protocol |
| title_full | A Prospective Study of Causes of Illness and Death in Preterm Infants in Ethiopia: The SIP Study Protocol |
| title_fullStr | A Prospective Study of Causes of Illness and Death in Preterm Infants in Ethiopia: The SIP Study Protocol |
| title_full_unstemmed | A Prospective Study of Causes of Illness and Death in Preterm Infants in Ethiopia: The SIP Study Protocol |
| title_short | A Prospective Study of Causes of Illness and Death in Preterm Infants in Ethiopia: The SIP Study Protocol |
| title_sort | prospective study of causes of illness and death in preterm infants in ethiopia the sip study protocol |
| topic | Neonatal mortality Preterm birth Low-middle income countries Cause of death |
| url | http://link.springer.com/article/10.1186/s12978-018-0555-y |
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