Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome

Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome

Methylation of histone H3K4 is a hallmark of actively transcribed genes that depends on mono-ubiquitination of histone H2B (H2B-Ub). H3K4 methylation in yeast is catalyzed by Set1, the methyltransferase subunit of COMPASS. We report here the cryo-EM structure of a six-protein core COMPASS subcomplex...

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Bibliographic Details
Main Authors: Evan J Worden, Xiangbin Zhang, Cynthia Wolberger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-01-01
Series:eLife
Subjects:
ubiquitin
histone methylation
chromatin
transcription
Online Access:https://elifesciences.org/articles/53199

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