COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells
The new pandemic of SARS-CoV-2 Betacoronavirus, has spread worldwide, and infected millions of individuals causing the disease denominated of COVID-19. Further on flu symptoms, due to the high tropism of virus, has most been observed in the COVID-19 pathophysiology: acute heart failure, thromboembo...
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| Format: | Article |
| Language: | English |
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Unidad Central del Valle del Cauca
2021-12-01
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| Series: | Magna Scientia UCEVA |
| Subjects: | |
| Online Access: | https://190.97.80.24:443/index.php/magnascientia/article/view/2 |
| _version_ | 1797296247526129664 |
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| author | Carla Longo de Freitas Priscilla Yuri Okochi Alves da silva Maria do Carmo Pinho Franco Danilo Candido de Almeida |
| author_facet | Carla Longo de Freitas Priscilla Yuri Okochi Alves da silva Maria do Carmo Pinho Franco Danilo Candido de Almeida |
| author_sort | Carla Longo de Freitas |
| collection | DOAJ |
| description |
The new pandemic of SARS-CoV-2 Betacoronavirus, has spread worldwide, and infected millions of individuals causing the disease denominated of COVID-19. Further on flu symptoms, due to the high tropism of virus, has most been observed in the COVID-19 pathophysiology: acute heart failure, thromboembolism events, acute renal failure, neurological and liver damage, and multiple organ failure, with special attention to endothelial disfunction. Hence, elucidate whether virus target the endothelium is a crucial step to understand COVID-19 pathogenesis. However, the permissiveness of blood vessels during SARS-CoV-2 infection remains unclear, but regardless endothelial infection, the vascular disfunction may occurred in response to molecular inflammatory signaling triggered by immune cells that attempt to limit infection. Thus, alternative therapies using mesenchymal stromal cells (MSCs) can change this scenario and help critically ill patients. In this reflection, we attempt to discuss COVID-19 pathophysiology with impact in endothelial function and explore the applicability of MSC-based therapies as alternative treatment.
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| first_indexed | 2024-03-07T22:00:42Z |
| format | Article |
| id | doaj.art-005f3921a8d24311839ed6ecffb3cbc9 |
| institution | Directory Open Access Journal |
| issn | 2805-6884 2805-6701 |
| language | English |
| last_indexed | 2024-03-07T22:00:42Z |
| publishDate | 2021-12-01 |
| publisher | Unidad Central del Valle del Cauca |
| record_format | Article |
| series | Magna Scientia UCEVA |
| spelling | doaj.art-005f3921a8d24311839ed6ecffb3cbc92024-02-24T04:31:49ZengUnidad Central del Valle del CaucaMagna Scientia UCEVA2805-68842805-67012021-12-0111COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal CellsCarla Longo de Freitas0Priscilla Yuri Okochi Alves da silva1Maria do Carmo Pinho Franco2Danilo Candido de Almeida3University of São Paulo, São Paulo, BrazilDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, BrazilDivision of Nephrology, Medicine Department, School of Medicine, Federal University of São Paulo, São Paulo, BrazilDivision of Nephrology, Medicine Department, School of Medicine, Federal University of São Paulo, São Paulo, Brazil The new pandemic of SARS-CoV-2 Betacoronavirus, has spread worldwide, and infected millions of individuals causing the disease denominated of COVID-19. Further on flu symptoms, due to the high tropism of virus, has most been observed in the COVID-19 pathophysiology: acute heart failure, thromboembolism events, acute renal failure, neurological and liver damage, and multiple organ failure, with special attention to endothelial disfunction. Hence, elucidate whether virus target the endothelium is a crucial step to understand COVID-19 pathogenesis. However, the permissiveness of blood vessels during SARS-CoV-2 infection remains unclear, but regardless endothelial infection, the vascular disfunction may occurred in response to molecular inflammatory signaling triggered by immune cells that attempt to limit infection. Thus, alternative therapies using mesenchymal stromal cells (MSCs) can change this scenario and help critically ill patients. In this reflection, we attempt to discuss COVID-19 pathophysiology with impact in endothelial function and explore the applicability of MSC-based therapies as alternative treatment. https://190.97.80.24:443/index.php/magnascientia/article/view/2COVID-19 pathophysiologyEndothelial disfunctionImmune cellsMesenchymal Stromal CellsPathogenesis |
| spellingShingle | Carla Longo de Freitas Priscilla Yuri Okochi Alves da silva Maria do Carmo Pinho Franco Danilo Candido de Almeida COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells Magna Scientia UCEVA COVID-19 pathophysiology Endothelial disfunction Immune cells Mesenchymal Stromal Cells Pathogenesis |
| title | COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells |
| title_full | COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells |
| title_fullStr | COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells |
| title_full_unstemmed | COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells |
| title_short | COVID-19: Impact in endothelial function and therapy with Mesenchymal Stromal Cells |
| title_sort | covid 19 impact in endothelial function and therapy with mesenchymal stromal cells |
| topic | COVID-19 pathophysiology Endothelial disfunction Immune cells Mesenchymal Stromal Cells Pathogenesis |
| url | https://190.97.80.24:443/index.php/magnascientia/article/view/2 |
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