Acute Increase in O-GlcNAc Improves Survival in Mice With LPS-Induced Systemic Inflammatory Response Syndrome

Acute Increase in O-GlcNAc Improves Survival in Mice With LPS-Induced Systemic Inflammatory Response Syndrome

Sepsis is a systemic inflammatory response syndrome (SIRS) resulting from a severe infection that is characterized by immune dysregulation, cardiovascular derangements, and end-organ dysfunction. The modification of proteins by O-linked N-acetylglucosamine (O-GlcNAcylation) influences many of the ke...

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Bibliographic Details
Main Authors: Josiane Fernandes Silva, Vania C. Olivon, Fabiola Leslie A. C. Mestriner, Camila Ziliotto Zanotto, Raphael Gomes Ferreira, Nathanne Santos Ferreira, Carlos Alberto Aguiar Silva, João Paulo Mesquita Luiz, Juliano Vilela Alves, Rubens Fazan, Fernando Queiróz Cunha, Jose Carlos Alves-Filho, Rita C. Tostes
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Physiology
Subjects:
O-GlcNAc
sepsis
LPS
inflammation
vascular reactivity
blood pressure
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01614/full

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