Vitamin D3 ameliorates nitrogen mustard‐induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3–SOD2–mtROS signaling pathway

Vitamin D3 ameliorates nitrogen mustard‐induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3–SOD2–mtROS signaling pathway

Abstract Nitrogen mustard (NM) causes severe skin injury with an obvious inflammatory response, which is lack of effective and targeted therapies. Vitamin D3 (VD3) has excellent anti‐inflammatory properties and is considered as a potential candidate for the treatment of NM‐induced dermal toxicity; h...

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Bibliographic Details
Main Authors: Xunhu Dong, Ying He, Feng Ye, Yuanpeng Zhao, Jin Cheng, Jingsong Xiao, Wenpei Yu, Jiqing Zhao, Yan Sai, Guorong Dan, Mingliang Chen, Zhongmin Zou
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Clinical and Translational Medicine
Subjects:
cutaneous inflammation
nitrogen mustard
NLRP3 inflammasome
SIRT3
vitamin D3
Online Access:https://doi.org/10.1002/ctm2.312

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