Multiple Targeting Approaches on Histamine H3 Receptor Antagonists

Multiple Targeting Approaches on Histamine H3 Receptor Antagonists

With the very recent market approval of pitolisant (Wakix®), the interest in clinical applications of novel multifunctional histamine H3 receptor antagonists has clearly increased. Since histamine H3 receptor antagonists in clinical development have been tested for a variety of different indications...

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Bibliographic Details
Main Authors: Mohammad eKhanfar, Anna eAffini, Kiril eLutsenko, Katarina eNikolic, Stefania eButini, Holger eStark
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Neuroscience
Subjects:
Enzymes
Histamine
transporter
NO
GPCR
Multiple targeting
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00201/full

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