Fatigue and Quality of Life in Children with Chronic Kidney Disease
Background: This study investigates the effect of chronic kidney disease (CKD) stage on fatigue and health-related quality of life (HRQoL) in the pediatric population. Material and Methods: The PedsQL (Pediatric Quality of Life Inventory) Multidimensional Fatigue Scale (subcategories: general, sleep...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/9/1414 |
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| author | Vasiliki Karava Sofia Goutou John Dotis Antonia Kondou Evangelia Charela Olympia Dadoudi Theodoros Eleftheriadis Ioannis Stefanidis Nikoleta Printza |
| author_facet | Vasiliki Karava Sofia Goutou John Dotis Antonia Kondou Evangelia Charela Olympia Dadoudi Theodoros Eleftheriadis Ioannis Stefanidis Nikoleta Printza |
| author_sort | Vasiliki Karava |
| collection | DOAJ |
| description | Background: This study investigates the effect of chronic kidney disease (CKD) stage on fatigue and health-related quality of life (HRQoL) in the pediatric population. Material and Methods: The PedsQL (Pediatric Quality of Life Inventory) Multidimensional Fatigue Scale (subcategories: general, sleep/rest, and cognitive fatigue) and HRQoL Generic Core Scales (subcategories: physical, emotional, social, and school functioning) questionnaires were completed by 30 patients aged from 7 to 18 years old with CKD stage 2–4, CKD stage 5 on dialysis (CKD 5D), and kidney transplantation (KTx), as well as their parents. Results: Both low “Total Fatigue” and “Total HRQoL” scores were reported in 16.7% of patients. “Sleep/Rest Fatigue”, “Emotional Functioning”, and “School functioning” were the lowest scored subcategories. CKD 5D/KTx patients presented lower “Sleep/Rest Fatigue” (<i>p</i> = 0.022) and, more frequently, low “School Functioning” scores (<i>p</i> = 0.029). The “Total HRQoL” score was correlated to the “Total Fatigue” score (rs = 0.625, <i>p</i> < 0.001). A low “Sleep/Rest Fatigue” score was associated with low “Physical Functioning”, “School Functioning”, and “Total HRQoL” scores (<i>p</i> = 0.016, <i>p</i> = 0.001, and <i>p</i> = 0.047 respectively). Parents’ HRQoL score was lower than patients’ score on “Physical Functioning” (<i>p</i> = 0.040) and “School Functioning” subcategories (<i>p</i> = 0.045). Conclusions: Fatigue and disturbed HRQoL are mostly observed in CKD 5D and KTx pediatric patients, and are associated with sleep disorders and school dysfunction. Fatigue affects HRQoL, which is perceived as more deteriorated by the patients’ parents. |
| first_indexed | 2024-03-10T00:22:23Z |
| format | Article |
| id | doaj.art-0067834d64694459a1511e961d395ac8 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T00:22:23Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-0067834d64694459a1511e961d395ac82023-11-23T15:38:42ZengMDPI AGChildren2227-90672022-09-0199141410.3390/children9091414Fatigue and Quality of Life in Children with Chronic Kidney DiseaseVasiliki Karava0Sofia Goutou1John Dotis2Antonia Kondou3Evangelia Charela4Olympia Dadoudi5Theodoros Eleftheriadis6Ioannis Stefanidis7Nikoleta Printza8Pediatric Nephrology Unit, 1st Department of Pediatrics, Hippokratio General Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, GreecePediatric Nephrology Unit, 1st Department of Pediatrics, Hippokratio General Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, GreecePediatric Nephrology Unit, 1st Department of Pediatrics, Hippokratio General Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, GreecePediatric Nephrology Unit, 1st Department of Pediatrics, Hippokratio General Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, GreecePediatric Nephrology Unit, 1st Department of Pediatrics, Hippokratio General Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, GreeceBSc Psychology, University of Birmingham, Birmingham B15 2TT, UKDivision of Nephrology, University Hospital of Larissa, University of Thessaly School of Medicine, 41334 Larissa, GreeceDivision of Nephrology, University Hospital of Larissa, University of Thessaly School of Medicine, 41334 Larissa, GreecePediatric Nephrology Unit, 1st Department of Pediatrics, Hippokratio General Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, GreeceBackground: This study investigates the effect of chronic kidney disease (CKD) stage on fatigue and health-related quality of life (HRQoL) in the pediatric population. Material and Methods: The PedsQL (Pediatric Quality of Life Inventory) Multidimensional Fatigue Scale (subcategories: general, sleep/rest, and cognitive fatigue) and HRQoL Generic Core Scales (subcategories: physical, emotional, social, and school functioning) questionnaires were completed by 30 patients aged from 7 to 18 years old with CKD stage 2–4, CKD stage 5 on dialysis (CKD 5D), and kidney transplantation (KTx), as well as their parents. Results: Both low “Total Fatigue” and “Total HRQoL” scores were reported in 16.7% of patients. “Sleep/Rest Fatigue”, “Emotional Functioning”, and “School functioning” were the lowest scored subcategories. CKD 5D/KTx patients presented lower “Sleep/Rest Fatigue” (<i>p</i> = 0.022) and, more frequently, low “School Functioning” scores (<i>p</i> = 0.029). The “Total HRQoL” score was correlated to the “Total Fatigue” score (rs = 0.625, <i>p</i> < 0.001). A low “Sleep/Rest Fatigue” score was associated with low “Physical Functioning”, “School Functioning”, and “Total HRQoL” scores (<i>p</i> = 0.016, <i>p</i> = 0.001, and <i>p</i> = 0.047 respectively). Parents’ HRQoL score was lower than patients’ score on “Physical Functioning” (<i>p</i> = 0.040) and “School Functioning” subcategories (<i>p</i> = 0.045). Conclusions: Fatigue and disturbed HRQoL are mostly observed in CKD 5D and KTx pediatric patients, and are associated with sleep disorders and school dysfunction. Fatigue affects HRQoL, which is perceived as more deteriorated by the patients’ parents.https://www.mdpi.com/2227-9067/9/9/1414PedsQLquestionnairekidney transplantationdialysissleepschool |
| spellingShingle | Vasiliki Karava Sofia Goutou John Dotis Antonia Kondou Evangelia Charela Olympia Dadoudi Theodoros Eleftheriadis Ioannis Stefanidis Nikoleta Printza Fatigue and Quality of Life in Children with Chronic Kidney Disease Children PedsQL questionnaire kidney transplantation dialysis sleep school |
| title | Fatigue and Quality of Life in Children with Chronic Kidney Disease |
| title_full | Fatigue and Quality of Life in Children with Chronic Kidney Disease |
| title_fullStr | Fatigue and Quality of Life in Children with Chronic Kidney Disease |
| title_full_unstemmed | Fatigue and Quality of Life in Children with Chronic Kidney Disease |
| title_short | Fatigue and Quality of Life in Children with Chronic Kidney Disease |
| title_sort | fatigue and quality of life in children with chronic kidney disease |
| topic | PedsQL questionnaire kidney transplantation dialysis sleep school |
| url | https://www.mdpi.com/2227-9067/9/9/1414 |
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