Management of Multiple Myeloma: A Review for General Practitioners in Oncology
Multiple myeloma (MM) is a malignant clonal plasma cell disorder in the bone marrow and is the second-most common hematologic malignancy in adults. Although patients with MM have a moderate life expectancy, it remains a heterogeneous disease that often requires multiple lines of chemotherapy for dur...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/30/5/334 |
| _version_ | 1827741590027763712 |
|---|---|
| author | Bethany E. Monteith Irwindeep Sandhu Ann S. Lee |
| author_facet | Bethany E. Monteith Irwindeep Sandhu Ann S. Lee |
| author_sort | Bethany E. Monteith |
| collection | DOAJ |
| description | Multiple myeloma (MM) is a malignant clonal plasma cell disorder in the bone marrow and is the second-most common hematologic malignancy in adults. Although patients with MM have a moderate life expectancy, it remains a heterogeneous disease that often requires multiple lines of chemotherapy for durable control and long-term survival. This review outlines current management strategies for both transplant-eligible and transplant-ineligible patients as well as for relapsed and refractory disease. Advances in drug therapies have widened management options and improved survival. In this paper, we also discuss implications for special populations and survivorship care. |
| first_indexed | 2024-03-11T03:49:16Z |
| format | Article |
| id | doaj.art-0067e073c92548b393026763617fe3f5 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-11T03:49:16Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-0067e073c92548b393026763617fe3f52023-11-18T01:01:10ZengMDPI AGCurrent Oncology1198-00521718-77292023-04-013054382440110.3390/curroncol30050334Management of Multiple Myeloma: A Review for General Practitioners in OncologyBethany E. Monteith0Irwindeep Sandhu1Ann S. Lee2Department of Medicine, Queen’s University, Kingston, ON K7L 3N6, CanadaDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton AB T6G 1Z2, CanadaDepartment of Family Medicine, University of Alberta, Edmonton, AB T6G 2T4, CanadaMultiple myeloma (MM) is a malignant clonal plasma cell disorder in the bone marrow and is the second-most common hematologic malignancy in adults. Although patients with MM have a moderate life expectancy, it remains a heterogeneous disease that often requires multiple lines of chemotherapy for durable control and long-term survival. This review outlines current management strategies for both transplant-eligible and transplant-ineligible patients as well as for relapsed and refractory disease. Advances in drug therapies have widened management options and improved survival. In this paper, we also discuss implications for special populations and survivorship care.https://www.mdpi.com/1718-7729/30/5/334multiple myelomalymphoproliferative disorderssurvivorship |
| spellingShingle | Bethany E. Monteith Irwindeep Sandhu Ann S. Lee Management of Multiple Myeloma: A Review for General Practitioners in Oncology Current Oncology multiple myeloma lymphoproliferative disorders survivorship |
| title | Management of Multiple Myeloma: A Review for General Practitioners in Oncology |
| title_full | Management of Multiple Myeloma: A Review for General Practitioners in Oncology |
| title_fullStr | Management of Multiple Myeloma: A Review for General Practitioners in Oncology |
| title_full_unstemmed | Management of Multiple Myeloma: A Review for General Practitioners in Oncology |
| title_short | Management of Multiple Myeloma: A Review for General Practitioners in Oncology |
| title_sort | management of multiple myeloma a review for general practitioners in oncology |
| topic | multiple myeloma lymphoproliferative disorders survivorship |
| url | https://www.mdpi.com/1718-7729/30/5/334 |
| work_keys_str_mv | AT bethanyemonteith managementofmultiplemyelomaareviewforgeneralpractitionersinoncology AT irwindeepsandhu managementofmultiplemyelomaareviewforgeneralpractitionersinoncology AT annslee managementofmultiplemyelomaareviewforgeneralpractitionersinoncology |