Diagnosis of leptospira by metagenomics next-generation sequencing with extracorporeal membrane oxygenation support: a case report
Abstract Background Leptospirosis is an infectious disease caused by pathogenic Leptospira spp., which could result in severe illnesses. Indirect contact with these pathogens is more common. Individuals could contract this disease through contact with contaminated water or during floods. In this cas...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-023-08793-w |
| _version_ | 1797577859103981568 |
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| author | Jianyu Ji Wei Wang Shulin Xiang Xiutian Wei Guangbao Pang Huirong Shi Jinda Dong Jing Pang |
| author_facet | Jianyu Ji Wei Wang Shulin Xiang Xiutian Wei Guangbao Pang Huirong Shi Jinda Dong Jing Pang |
| author_sort | Jianyu Ji |
| collection | DOAJ |
| description | Abstract Background Leptospirosis is an infectious disease caused by pathogenic Leptospira spp., which could result in severe illnesses. Indirect contact with these pathogens is more common. Individuals could contract this disease through contact with contaminated water or during floods. In this case, we present the details of a 40-year-old male pig farmer who suffered from severe pulmonary hemorrhagic leptospirosis and multiple organ failure. The diagnosis of leptospirosis was confirmed through metagenomics next-generation sequencing (mNGS) while the patient received extracorporeal membrane oxygenation (ECMO) support, and antibiotic treatment was adjusted accordingly. The patient underwent comprehensive treatment and rehabilitation in the intensive care unit. Conclusion This case illustrates the importance of early diagnosis and treatment of leptospirosis. While obtaining the epidemiological history, second-generation metagenomics sequencing was utilized to confirm the etiology. The prompt initiation of ECMO therapy provided a crucial window of opportunity for addressing the underlying cause. This case report offers valuable insights for diagnosing patients with similar symptoms. |
| first_indexed | 2024-03-10T22:13:57Z |
| format | Article |
| id | doaj.art-0068641c01a04310a7d2ef326cb70415 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-10T22:13:57Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-0068641c01a04310a7d2ef326cb704152023-11-19T12:29:34ZengBMCBMC Infectious Diseases1471-23342023-11-012311710.1186/s12879-023-08793-wDiagnosis of leptospira by metagenomics next-generation sequencing with extracorporeal membrane oxygenation support: a case reportJianyu Ji0Wei Wang1Shulin Xiang2Xiutian Wei3Guangbao Pang4Huirong Shi5Jinda Dong6Jing Pang7Research Center of Communicable and Severe Diseases, Department of Intensive Care Unit, Guangxi Academy of Medical Sciences, The People’s Hospital of Guangxi Zhuang Autonomous RegionResearch Center of Communicable and Severe Diseases, Department of Intensive Care Unit, Guangxi Academy of Medical Sciences, The People’s Hospital of Guangxi Zhuang Autonomous RegionResearch Center of Communicable and Severe Diseases, Department of Intensive Care Unit, Guangxi Academy of Medical Sciences, The People’s Hospital of Guangxi Zhuang Autonomous RegionResearch Center of Communicable and Severe Diseases, Department of Intensive Care Unit, Guangxi Academy of Medical Sciences, The People’s Hospital of Guangxi Zhuang Autonomous RegionResearch Center of Communicable and Severe Diseases, Department of Intensive Care Unit, Guangxi Academy of Medical Sciences, The People’s Hospital of Guangxi Zhuang Autonomous RegionResearch Center of Communicable and Severe Diseases, Department of Intensive Care Unit, Guangxi Academy of Medical Sciences, The People’s Hospital of Guangxi Zhuang Autonomous RegionDepartment of blood transfusion, The People’s Hospital of Guangxi Zhuang Autonomous RegionResearch Center of Communicable and Severe Diseases, Department of Intensive Care Unit, Guangxi Academy of Medical Sciences, The People’s Hospital of Guangxi Zhuang Autonomous RegionAbstract Background Leptospirosis is an infectious disease caused by pathogenic Leptospira spp., which could result in severe illnesses. Indirect contact with these pathogens is more common. Individuals could contract this disease through contact with contaminated water or during floods. In this case, we present the details of a 40-year-old male pig farmer who suffered from severe pulmonary hemorrhagic leptospirosis and multiple organ failure. The diagnosis of leptospirosis was confirmed through metagenomics next-generation sequencing (mNGS) while the patient received extracorporeal membrane oxygenation (ECMO) support, and antibiotic treatment was adjusted accordingly. The patient underwent comprehensive treatment and rehabilitation in the intensive care unit. Conclusion This case illustrates the importance of early diagnosis and treatment of leptospirosis. While obtaining the epidemiological history, second-generation metagenomics sequencing was utilized to confirm the etiology. The prompt initiation of ECMO therapy provided a crucial window of opportunity for addressing the underlying cause. This case report offers valuable insights for diagnosing patients with similar symptoms.https://doi.org/10.1186/s12879-023-08793-wLeptospirosisMetagenomics next-generation sequencingExtracorporeal membrane oxygenationMulti-organ failure |
| spellingShingle | Jianyu Ji Wei Wang Shulin Xiang Xiutian Wei Guangbao Pang Huirong Shi Jinda Dong Jing Pang Diagnosis of leptospira by metagenomics next-generation sequencing with extracorporeal membrane oxygenation support: a case report BMC Infectious Diseases Leptospirosis Metagenomics next-generation sequencing Extracorporeal membrane oxygenation Multi-organ failure |
| title | Diagnosis of leptospira by metagenomics next-generation sequencing with extracorporeal membrane oxygenation support: a case report |
| title_full | Diagnosis of leptospira by metagenomics next-generation sequencing with extracorporeal membrane oxygenation support: a case report |
| title_fullStr | Diagnosis of leptospira by metagenomics next-generation sequencing with extracorporeal membrane oxygenation support: a case report |
| title_full_unstemmed | Diagnosis of leptospira by metagenomics next-generation sequencing with extracorporeal membrane oxygenation support: a case report |
| title_short | Diagnosis of leptospira by metagenomics next-generation sequencing with extracorporeal membrane oxygenation support: a case report |
| title_sort | diagnosis of leptospira by metagenomics next generation sequencing with extracorporeal membrane oxygenation support a case report |
| topic | Leptospirosis Metagenomics next-generation sequencing Extracorporeal membrane oxygenation Multi-organ failure |
| url | https://doi.org/10.1186/s12879-023-08793-w |
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