Drosophila DNA-Binding Proteins in Polycomb Repression
The formation of individual gene expression patterns in different cell types is required during differentiation and development of multicellular organisms. Polycomb group (PcG) proteins are key epigenetic regulators responsible for gene repression, and dysregulation of their activities leads to deve...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-01-01
|
| Series: | Epigenomes |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2075-4655/2/1/1 |
| _version_ | 1827880304852860928 |
|---|---|
| author | Maksim Erokhin Pavel Georgiev Darya Chetverina |
| author_facet | Maksim Erokhin Pavel Georgiev Darya Chetverina |
| author_sort | Maksim Erokhin |
| collection | DOAJ |
| description | The formation of individual gene expression patterns in different cell types is required during differentiation and development of multicellular organisms. Polycomb group (PcG) proteins are key epigenetic regulators responsible for gene repression, and dysregulation of their activities leads to developmental abnormalities and diseases. PcG proteins were first identified in Drosophila, which still remains the most convenient system for studying PcG-dependent repression. In the Drosophila genome, these proteins bind to DNA regions called Polycomb response elements (PREs). A major role in the recruitment of PcG proteins to PREs is played by DNA-binding factors, several of which have been characterized in detail. However, current knowledge is insufficient for comprehensively describing the mechanism of this process. In this review, we summarize and discuss the available data on the role of DNA-binding proteins in PcG recruitment to chromatin. |
| first_indexed | 2024-03-12T18:20:44Z |
| format | Article |
| id | doaj.art-006983b7b2864e92afb7316b5aa479a8 |
| institution | Directory Open Access Journal |
| issn | 2075-4655 |
| language | English |
| last_indexed | 2024-03-12T18:20:44Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Epigenomes |
| spelling | doaj.art-006983b7b2864e92afb7316b5aa479a82023-08-02T08:55:25ZengMDPI AGEpigenomes2075-46552018-01-0121110.3390/epigenomes2010001epigenomes2010001Drosophila DNA-Binding Proteins in Polycomb RepressionMaksim Erokhin0Pavel Georgiev1Darya Chetverina2Department of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, RussiaDepartment of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, RussiaDepartment of the Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, RussiaThe formation of individual gene expression patterns in different cell types is required during differentiation and development of multicellular organisms. Polycomb group (PcG) proteins are key epigenetic regulators responsible for gene repression, and dysregulation of their activities leads to developmental abnormalities and diseases. PcG proteins were first identified in Drosophila, which still remains the most convenient system for studying PcG-dependent repression. In the Drosophila genome, these proteins bind to DNA regions called Polycomb response elements (PREs). A major role in the recruitment of PcG proteins to PREs is played by DNA-binding factors, several of which have been characterized in detail. However, current knowledge is insufficient for comprehensively describing the mechanism of this process. In this review, we summarize and discuss the available data on the role of DNA-binding proteins in PcG recruitment to chromatin.http://www.mdpi.com/2075-4655/2/1/1DNA bindingPolycombPolycomb response elementsPRErecruitmentepigeneticschromatintranscription regulationrepressionsilencing |
| spellingShingle | Maksim Erokhin Pavel Georgiev Darya Chetverina Drosophila DNA-Binding Proteins in Polycomb Repression Epigenomes DNA binding Polycomb Polycomb response elements PRE recruitment epigenetics chromatin transcription regulation repression silencing |
| title | Drosophila DNA-Binding Proteins in Polycomb Repression |
| title_full | Drosophila DNA-Binding Proteins in Polycomb Repression |
| title_fullStr | Drosophila DNA-Binding Proteins in Polycomb Repression |
| title_full_unstemmed | Drosophila DNA-Binding Proteins in Polycomb Repression |
| title_short | Drosophila DNA-Binding Proteins in Polycomb Repression |
| title_sort | drosophila dna binding proteins in polycomb repression |
| topic | DNA binding Polycomb Polycomb response elements PRE recruitment epigenetics chromatin transcription regulation repression silencing |
| url | http://www.mdpi.com/2075-4655/2/1/1 |
| work_keys_str_mv | AT maksimerokhin drosophiladnabindingproteinsinpolycombrepression AT pavelgeorgiev drosophiladnabindingproteinsinpolycombrepression AT daryachetverina drosophiladnabindingproteinsinpolycombrepression |