Effect of Temperature and Humidity on the Allegro-inflammatory Factors and Allergic Rhinitis-related Behavior
Allergic rhinitis (AR) is an allergic disease induced by the T helper 2 (TH2) lymphocyte immune response, where its mediators are the primary cause of clinical symptoms. Environmental factors are the primary determinants of the allergic response in genetically susceptible individuals. This study in...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2022-12-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3545 |
| _version_ | 1828054730889232384 |
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| author | Shen Yonghua Entezar Mehrabi Nasab Yen Liuo |
| author_facet | Shen Yonghua Entezar Mehrabi Nasab Yen Liuo |
| author_sort | Shen Yonghua |
| collection | DOAJ |
| description |
Allergic rhinitis (AR) is an allergic disease induced by the T helper 2 (TH2) lymphocyte immune response, where its mediators are the primary cause of clinical symptoms. Environmental factors are the primary determinants of the allergic response in genetically susceptible individuals. This study investigates the effects of climate conditions (warm, cold, humid, and dry) on allergic rhinitis.
AR models were created in mice under 4 different conditions. We investigated AR-related behavior (sneezing and nose rubbing), as well as total immunoglobulin E (IgE), histamine, interleukin-4 (IL-4), leukotriene (LT) B4 and LTC4 levels, and gene expression of CysLT1R, HRH1, and MUC5a.
Nose rubbing, histamine levels, and the expression of MUC5a and HRH1 were increased in AR models in cold conditions, and sneezing was increased in AR models kept in dry conditions. LTB4 and LTC4 levels and the expression of CysLT1R in AR models kept in a wet environment also significantly increased compared with the control group. The levels of total IgE and IL-4 showed no significant changes.
Air temperature and humidity affect AR pathophysiology, and weather conditions can be essential in controlling AR.
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| first_indexed | 2024-04-10T20:28:06Z |
| format | Article |
| id | doaj.art-006a139f09df4dcdba8212ca98aafd67 |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-04-10T20:28:06Z |
| publishDate | 2022-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-006a139f09df4dcdba8212ca98aafd672023-01-25T07:43:22ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492022-12-0121610.18502/ijaai.v21i6.11531Effect of Temperature and Humidity on the Allegro-inflammatory Factors and Allergic Rhinitis-related BehaviorShen Yonghua0Entezar Mehrabi Nasab1Yen Liuo2Department of Otolaryngology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Jiangsu, ChinaDepartment of Cardiology, School of Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, IranOtorhinolaryngology Head and Neck Surgery, HongiHui Hospital, Xi’an University, Xi'an, China Allergic rhinitis (AR) is an allergic disease induced by the T helper 2 (TH2) lymphocyte immune response, where its mediators are the primary cause of clinical symptoms. Environmental factors are the primary determinants of the allergic response in genetically susceptible individuals. This study investigates the effects of climate conditions (warm, cold, humid, and dry) on allergic rhinitis. AR models were created in mice under 4 different conditions. We investigated AR-related behavior (sneezing and nose rubbing), as well as total immunoglobulin E (IgE), histamine, interleukin-4 (IL-4), leukotriene (LT) B4 and LTC4 levels, and gene expression of CysLT1R, HRH1, and MUC5a. Nose rubbing, histamine levels, and the expression of MUC5a and HRH1 were increased in AR models in cold conditions, and sneezing was increased in AR models kept in dry conditions. LTB4 and LTC4 levels and the expression of CysLT1R in AR models kept in a wet environment also significantly increased compared with the control group. The levels of total IgE and IL-4 showed no significant changes. Air temperature and humidity affect AR pathophysiology, and weather conditions can be essential in controlling AR. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3545Gene expressionHistamineLeukotrienesSneezing |
| spellingShingle | Shen Yonghua Entezar Mehrabi Nasab Yen Liuo Effect of Temperature and Humidity on the Allegro-inflammatory Factors and Allergic Rhinitis-related Behavior Iranian Journal of Allergy, Asthma and Immunology Gene expression Histamine Leukotrienes Sneezing |
| title | Effect of Temperature and Humidity on the Allegro-inflammatory Factors and Allergic Rhinitis-related Behavior |
| title_full | Effect of Temperature and Humidity on the Allegro-inflammatory Factors and Allergic Rhinitis-related Behavior |
| title_fullStr | Effect of Temperature and Humidity on the Allegro-inflammatory Factors and Allergic Rhinitis-related Behavior |
| title_full_unstemmed | Effect of Temperature and Humidity on the Allegro-inflammatory Factors and Allergic Rhinitis-related Behavior |
| title_short | Effect of Temperature and Humidity on the Allegro-inflammatory Factors and Allergic Rhinitis-related Behavior |
| title_sort | effect of temperature and humidity on the allegro inflammatory factors and allergic rhinitis related behavior |
| topic | Gene expression Histamine Leukotrienes Sneezing |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3545 |
| work_keys_str_mv | AT shenyonghua effectoftemperatureandhumidityontheallegroinflammatoryfactorsandallergicrhinitisrelatedbehavior AT entezarmehrabinasab effectoftemperatureandhumidityontheallegroinflammatoryfactorsandallergicrhinitisrelatedbehavior AT yenliuo effectoftemperatureandhumidityontheallegroinflammatoryfactorsandallergicrhinitisrelatedbehavior |