Mechanisms for regulation of RAS palmitoylation and plasma membrane trafficking in hematopoietic malignancies
Palmitoylation is a critical posttranslational modification that enables the cellular membrane localization and subsequent activation of RAS proteins, including HRAS, KRAS, and NRAS. However, the molecular mechanism that regulates RAS palmitoylation in malignant diseases remains unclear. In this iss...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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American Society for Clinical Investigation
2023-06-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI171104 |
| _version_ | 1797634405569658880 |
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| author | Fang Yu Zhijian Qian |
| author_facet | Fang Yu Zhijian Qian |
| author_sort | Fang Yu |
| collection | DOAJ |
| description | Palmitoylation is a critical posttranslational modification that enables the cellular membrane localization and subsequent activation of RAS proteins, including HRAS, KRAS, and NRAS. However, the molecular mechanism that regulates RAS palmitoylation in malignant diseases remains unclear. In this issue of the JCI, Ren, Xing, and authors shed light on this topic and revealed how upregulation of RAB27B, as a consequence of CBL loss and Janus kinase 2 (JAK2) activation, contributes to leukemogenesis. The authors found that RAB27B mediated NRAS palmitoylation and plasma membrane localization by recruiting ZDHHC9. The findings suggest that targeting RAB27B could provide a promising therapeutic strategy for NRAS-driven cancers. |
| first_indexed | 2024-03-11T12:08:22Z |
| format | Article |
| id | doaj.art-006ad66114364133b740fbdc988154ec |
| institution | Directory Open Access Journal |
| issn | 1558-8238 |
| language | English |
| last_indexed | 2024-03-11T12:08:22Z |
| publishDate | 2023-06-01 |
| publisher | American Society for Clinical Investigation |
| record_format | Article |
| series | The Journal of Clinical Investigation |
| spelling | doaj.art-006ad66114364133b740fbdc988154ec2023-11-07T16:20:29ZengAmerican Society for Clinical InvestigationThe Journal of Clinical Investigation1558-82382023-06-0113312Mechanisms for regulation of RAS palmitoylation and plasma membrane trafficking in hematopoietic malignanciesFang YuZhijian QianPalmitoylation is a critical posttranslational modification that enables the cellular membrane localization and subsequent activation of RAS proteins, including HRAS, KRAS, and NRAS. However, the molecular mechanism that regulates RAS palmitoylation in malignant diseases remains unclear. In this issue of the JCI, Ren, Xing, and authors shed light on this topic and revealed how upregulation of RAB27B, as a consequence of CBL loss and Janus kinase 2 (JAK2) activation, contributes to leukemogenesis. The authors found that RAB27B mediated NRAS palmitoylation and plasma membrane localization by recruiting ZDHHC9. The findings suggest that targeting RAB27B could provide a promising therapeutic strategy for NRAS-driven cancers.https://doi.org/10.1172/JCI171104 |
| spellingShingle | Fang Yu Zhijian Qian Mechanisms for regulation of RAS palmitoylation and plasma membrane trafficking in hematopoietic malignancies The Journal of Clinical Investigation |
| title | Mechanisms for regulation of RAS palmitoylation and plasma membrane trafficking in hematopoietic malignancies |
| title_full | Mechanisms for regulation of RAS palmitoylation and plasma membrane trafficking in hematopoietic malignancies |
| title_fullStr | Mechanisms for regulation of RAS palmitoylation and plasma membrane trafficking in hematopoietic malignancies |
| title_full_unstemmed | Mechanisms for regulation of RAS palmitoylation and plasma membrane trafficking in hematopoietic malignancies |
| title_short | Mechanisms for regulation of RAS palmitoylation and plasma membrane trafficking in hematopoietic malignancies |
| title_sort | mechanisms for regulation of ras palmitoylation and plasma membrane trafficking in hematopoietic malignancies |
| url | https://doi.org/10.1172/JCI171104 |
| work_keys_str_mv | AT fangyu mechanismsforregulationofraspalmitoylationandplasmamembranetraffickinginhematopoieticmalignancies AT zhijianqian mechanismsforregulationofraspalmitoylationandplasmamembranetraffickinginhematopoieticmalignancies |