Hearing loss is associated with gray matter differences in older adults at risk for and with Alzheimer’s disease
Using data from the COMPASS-ND study we investigated associations between hearing loss and hippocampal volume as well as cortical thickness in older adults with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer’s dementia (AD). SCD participants with greater pure-tone...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
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| Series: | Aging Brain |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589958921000141 |
| _version_ | 1818873619682426880 |
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| author | N. Giroud M.K. Pichora-Fuller P. Mick W. Wittich F. Al-Yawer S. Rehan J.B. Orange N.A. Phillips |
| author_facet | N. Giroud M.K. Pichora-Fuller P. Mick W. Wittich F. Al-Yawer S. Rehan J.B. Orange N.A. Phillips |
| author_sort | N. Giroud |
| collection | DOAJ |
| description | Using data from the COMPASS-ND study we investigated associations between hearing loss and hippocampal volume as well as cortical thickness in older adults with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer’s dementia (AD). SCD participants with greater pure-tone hearing loss exhibited lower hippocampal volume, but more cortical thickness in the left superior temporal gyrus and right pars opercularis. Greater speech-in-noise reception thresholds were associated with lower cortical thickness bilaterally across much of the cortex in AD. The AD group also showed a trend towards worse speech-in-noise thresholds compared to the SCD group. |
| first_indexed | 2024-12-19T12:57:35Z |
| format | Article |
| id | doaj.art-006c67151d634a3baa537e420bf67749 |
| institution | Directory Open Access Journal |
| issn | 2589-9589 |
| language | English |
| last_indexed | 2024-12-19T12:57:35Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aging Brain |
| spelling | doaj.art-006c67151d634a3baa537e420bf677492022-12-21T20:20:21ZengElsevierAging Brain2589-95892021-01-011100018Hearing loss is associated with gray matter differences in older adults at risk for and with Alzheimer’s diseaseN. Giroud0M.K. Pichora-Fuller1P. Mick2W. Wittich3F. Al-Yawer4S. Rehan5J.B. Orange6N.A. Phillips7Department of Psychology, Centre for Research in Human Development, Concordia University, Montréal, Québec, Canada; Centre for Research on Brain, Language, and Music, Montréal, Québec, CanadaDepartment of Psychology, University of Toronto, Mississauga, Ontario, CanadaDepartment of Surgery, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, CanadaSchool of Optometry, Université de Montréal, Montreal, Quebec, CanadaDepartment of Psychology, Centre for Research in Human Development, Concordia University, Montréal, Québec, CanadaDepartment of Psychology, Centre for Research in Human Development, Concordia University, Montréal, Québec, CanadaSchool of Communication Sciences and Disorders, Western University, London, CanadaDepartment of Psychology, Centre for Research in Human Development, Concordia University, Montréal, Québec, Canada; Centre for Research on Brain, Language, and Music, Montréal, Québec, Canada; Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada; Corresponding author at: Department of Psychology, Concordia University, Cognition, Aging, and Psychophysiology Laboratory, 7141 Sherbrooke Street West, H4B 1R6 Montreal, Quebec, Canada.Using data from the COMPASS-ND study we investigated associations between hearing loss and hippocampal volume as well as cortical thickness in older adults with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer’s dementia (AD). SCD participants with greater pure-tone hearing loss exhibited lower hippocampal volume, but more cortical thickness in the left superior temporal gyrus and right pars opercularis. Greater speech-in-noise reception thresholds were associated with lower cortical thickness bilaterally across much of the cortex in AD. The AD group also showed a trend towards worse speech-in-noise thresholds compared to the SCD group.http://www.sciencedirect.com/science/article/pii/S2589958921000141Subjective cognitive declineMild cognitive impairmentAlzheimer’s dementiaHearing lossCLSA |
| spellingShingle | N. Giroud M.K. Pichora-Fuller P. Mick W. Wittich F. Al-Yawer S. Rehan J.B. Orange N.A. Phillips Hearing loss is associated with gray matter differences in older adults at risk for and with Alzheimer’s disease Aging Brain Subjective cognitive decline Mild cognitive impairment Alzheimer’s dementia Hearing loss CLSA |
| title | Hearing loss is associated with gray matter differences in older adults at risk for and with Alzheimer’s disease |
| title_full | Hearing loss is associated with gray matter differences in older adults at risk for and with Alzheimer’s disease |
| title_fullStr | Hearing loss is associated with gray matter differences in older adults at risk for and with Alzheimer’s disease |
| title_full_unstemmed | Hearing loss is associated with gray matter differences in older adults at risk for and with Alzheimer’s disease |
| title_short | Hearing loss is associated with gray matter differences in older adults at risk for and with Alzheimer’s disease |
| title_sort | hearing loss is associated with gray matter differences in older adults at risk for and with alzheimer s disease |
| topic | Subjective cognitive decline Mild cognitive impairment Alzheimer’s dementia Hearing loss CLSA |
| url | http://www.sciencedirect.com/science/article/pii/S2589958921000141 |
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