Molecular profiling of a real-world breast cancer cohort with genetically inferred ancestries reveals actionable tumor biology differences between European ancestry and African ancestry patient populations

Molecular profiling of a real-world breast cancer cohort with genetically inferred ancestries reveals actionable tumor biology differences between European ancestry and African ancestry patient populations

Abstract Background Endocrine-resistant HR+/HER2- breast cancer (BC) and triple-negative BC (TNBC) are of interest for molecularly informed treatment due to their aggressive natures and limited treatment profiles. Patients of African Ancestry (AA) experience higher rates of TNBC and mortality than E...

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Bibliographic Details
Main Authors: Minoru Miyashita, Joshua S. K. Bell, Stephane Wenric, Ezgi Karaesmen, Brooke Rhead, Matthew Kase, Kristiyana Kaneva, Francisco M. De La Vega, Yonglan Zheng, Toshio F. Yoshimatsu, Galina Khramtsova, Fang Liu, Fangyuan Zhao, Frederick M. Howard, Rita Nanda, Nike Beaubier, Kevin P. White, Dezheng Huo, Olufunmilayo I. Olopade
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Ancestry
Genomics
Transcriptomics
Online Access:https://doi.org/10.1186/s13058-023-01627-2

Internet

https://doi.org/10.1186/s13058-023-01627-2

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