Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection
Poly(ADP) ribose polymerase (PARP) activity promotes, but is not required for, chromosome break repair by polymerase theta-mediated end joining (TMEJ). PARP activity promotes TMEJ by stimulating resection, a process that controls pathway choice.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32166-7 |
| _version_ | 1811345222870761472 |
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| author | Megan E. Luedeman Susanna Stroik Wanjuan Feng Adam J. Luthman Gaorav P. Gupta Dale A. Ramsden |
| author_facet | Megan E. Luedeman Susanna Stroik Wanjuan Feng Adam J. Luthman Gaorav P. Gupta Dale A. Ramsden |
| author_sort | Megan E. Luedeman |
| collection | DOAJ |
| description | Poly(ADP) ribose polymerase (PARP) activity promotes, but is not required for, chromosome break repair by polymerase theta-mediated end joining (TMEJ). PARP activity promotes TMEJ by stimulating resection, a process that controls pathway choice. |
| first_indexed | 2024-04-13T19:59:48Z |
| format | Article |
| id | doaj.art-006e3279553f49e2bd2debeaa1b1755c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T19:59:48Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-006e3279553f49e2bd2debeaa1b1755c2022-12-22T02:32:14ZengNature PortfolioNature Communications2041-17232022-08-0113111010.1038/s41467-022-32166-7Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resectionMegan E. Luedeman0Susanna Stroik1Wanjuan Feng2Adam J. Luthman3Gaorav P. Gupta4Dale A. Ramsden5Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel HillLineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillLineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel HillCurriculum in Genetics and Molecular Biology, University of North Carolina at Chapel HillCurriculum in Genetics and Molecular Biology, University of North Carolina at Chapel HillPoly(ADP) ribose polymerase (PARP) activity promotes, but is not required for, chromosome break repair by polymerase theta-mediated end joining (TMEJ). PARP activity promotes TMEJ by stimulating resection, a process that controls pathway choice.https://doi.org/10.1038/s41467-022-32166-7 |
| spellingShingle | Megan E. Luedeman Susanna Stroik Wanjuan Feng Adam J. Luthman Gaorav P. Gupta Dale A. Ramsden Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection Nature Communications |
| title | Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection |
| title_full | Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection |
| title_fullStr | Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection |
| title_full_unstemmed | Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection |
| title_short | Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection |
| title_sort | poly adp ribose polymerase promotes dna polymerase theta mediated end joining by activation of end resection |
| url | https://doi.org/10.1038/s41467-022-32166-7 |
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