Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection

Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection

Poly(ADP) ribose polymerase (PARP) activity promotes, but is not required for, chromosome break repair by polymerase theta-mediated end joining (TMEJ). PARP activity promotes TMEJ by stimulating resection, a process that controls pathway choice.

Bibliographic Details
Main Authors: Megan E. Luedeman, Susanna Stroik, Wanjuan Feng, Adam J. Luthman, Gaorav P. Gupta, Dale A. Ramsden
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32166-7

Internet

https://doi.org/10.1038/s41467-022-32166-7

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