Dying to Defend: Neutrophil Death Pathways and their Implications in Immunity
Abstract Neutrophils, accounting for ≈70% of human peripheral leukocytes, are key cells countering bacterial and fungal infections. Neutrophil homeostasis involves a balance between cell maturation, migration, aging, and eventual death. Neutrophils undergo different death pathways depending on their...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202306457 |
| _version_ | 1827197103212855296 |
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| author | Haiyue Tu Haoyu Ren Junjie Jiang Changshun Shao Yufang Shi Peishan Li |
| author_facet | Haiyue Tu Haoyu Ren Junjie Jiang Changshun Shao Yufang Shi Peishan Li |
| author_sort | Haiyue Tu |
| collection | DOAJ |
| description | Abstract Neutrophils, accounting for ≈70% of human peripheral leukocytes, are key cells countering bacterial and fungal infections. Neutrophil homeostasis involves a balance between cell maturation, migration, aging, and eventual death. Neutrophils undergo different death pathways depending on their interactions with microbes and external environmental cues. Neutrophil death has significant physiological implications and leads to distinct immunological outcomes. This review discusses the multifarious neutrophil death pathways, including apoptosis, NETosis, pyroptosis, necroptosis, and ferroptosis, and outlines their effects on immune responses and disease progression. Understanding the multifaceted aspects of neutrophil death, the intersections among signaling pathways and ramifications of immunity will help facilitate the development of novel therapeutic methods. |
| first_indexed | 2024-03-07T22:48:08Z |
| format | Article |
| id | doaj.art-006ebbb2f9a54fa89054d2b39c725abd |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2025-03-21T09:55:48Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-006ebbb2f9a54fa89054d2b39c725abd2024-07-05T09:51:16ZengWileyAdvanced Science2198-38442024-02-01118n/an/a10.1002/advs.202306457Dying to Defend: Neutrophil Death Pathways and their Implications in ImmunityHaiyue Tu0Haoyu Ren1Junjie Jiang2Changshun Shao3Yufang Shi4Peishan Li5The First Affiliated Hospital of Soochow University State Key Laboratory of Radiation Medicine and Protection Institutes for Translational Medicine Suzhou Medical College of Soochow University Suzhou Jiangsu 215123 ChinaThe First Affiliated Hospital of Soochow University State Key Laboratory of Radiation Medicine and Protection Institutes for Translational Medicine Suzhou Medical College of Soochow University Suzhou Jiangsu 215123 ChinaThe First Affiliated Hospital of Soochow University State Key Laboratory of Radiation Medicine and Protection Institutes for Translational Medicine Suzhou Medical College of Soochow University Suzhou Jiangsu 215123 ChinaThe First Affiliated Hospital of Soochow University State Key Laboratory of Radiation Medicine and Protection Institutes for Translational Medicine Suzhou Medical College of Soochow University Suzhou Jiangsu 215123 ChinaThe First Affiliated Hospital of Soochow University State Key Laboratory of Radiation Medicine and Protection Institutes for Translational Medicine Suzhou Medical College of Soochow University Suzhou Jiangsu 215123 ChinaThe First Affiliated Hospital of Soochow University State Key Laboratory of Radiation Medicine and Protection Institutes for Translational Medicine Suzhou Medical College of Soochow University Suzhou Jiangsu 215123 ChinaAbstract Neutrophils, accounting for ≈70% of human peripheral leukocytes, are key cells countering bacterial and fungal infections. Neutrophil homeostasis involves a balance between cell maturation, migration, aging, and eventual death. Neutrophils undergo different death pathways depending on their interactions with microbes and external environmental cues. Neutrophil death has significant physiological implications and leads to distinct immunological outcomes. This review discusses the multifarious neutrophil death pathways, including apoptosis, NETosis, pyroptosis, necroptosis, and ferroptosis, and outlines their effects on immune responses and disease progression. Understanding the multifaceted aspects of neutrophil death, the intersections among signaling pathways and ramifications of immunity will help facilitate the development of novel therapeutic methods.https://doi.org/10.1002/advs.202306457ferroptosisnecroptosisNETosisneutrophil apoptosispyroptosis |
| spellingShingle | Haiyue Tu Haoyu Ren Junjie Jiang Changshun Shao Yufang Shi Peishan Li Dying to Defend: Neutrophil Death Pathways and their Implications in Immunity Advanced Science ferroptosis necroptosis NETosis neutrophil apoptosis pyroptosis |
| title | Dying to Defend: Neutrophil Death Pathways and their Implications in Immunity |
| title_full | Dying to Defend: Neutrophil Death Pathways and their Implications in Immunity |
| title_fullStr | Dying to Defend: Neutrophil Death Pathways and their Implications in Immunity |
| title_full_unstemmed | Dying to Defend: Neutrophil Death Pathways and their Implications in Immunity |
| title_short | Dying to Defend: Neutrophil Death Pathways and their Implications in Immunity |
| title_sort | dying to defend neutrophil death pathways and their implications in immunity |
| topic | ferroptosis necroptosis NETosis neutrophil apoptosis pyroptosis |
| url | https://doi.org/10.1002/advs.202306457 |
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