An Ultrafast UPLC–MS/MS Method for Characterizing the In Vitro Metabolic Stability of Acalabrutinib

An Ultrafast UPLC–MS/MS Method for Characterizing the In Vitro Metabolic Stability of Acalabrutinib

Acalabrutinib, commercially known as Calquence<sup>®</sup>, is a pharmacological molecule that has robust inhibitory activity against Bruton tyrosine kinase. The medicine in question was carefully developed by the esteemed pharmaceutical company AstraZeneca. The FDA granted authorization...

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Bibliographic Details
Main Authors: Mohamed W. Attwa, Ahmed H. Bakheit, Ali S. Abdelhameed, Adnan A. Kadi
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Molecules
Subjects:
acalabrutinib
intrinsic clearance
in vitro half-life
metabolic stability
P450 metabolic program
UPLC–MS/MS
Online Access:https://www.mdpi.com/1420-3049/28/20/7220

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