Cisplatin Concentrations in Long and Short Duration Infusion: Implications for the Optimal Time of Radiation Delivery
Introduction: Cisplatin has radiosensitizing properties and the best sensitization to radiotherapy occurs with a higher plasma concentration of cisplatin. To our knowledge the optimal time sequence between chemotherapy and administration of radiation therapy, to obtain maximum effect from concur...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8126/18181_CE(RA1)_F(T)_PF1(ROAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Cisplatin has radiosensitizing properties and the
best sensitization to radiotherapy occurs with a higher plasma
concentration of cisplatin. To our knowledge the optimal
time sequence between chemotherapy and administration of
radiation therapy, to obtain maximum effect from concurrent
chemoradiation is unclear.
Aim: The aim of this study was to measure the two cisplatin
infusion regimens in order to determine the total and free
cisplatin post infusion concentration changes over time. These
changes may have clinical implications on the optimum time of
administration of post infusion radiation therapy.
Materials and Methods: Two cohorts of patients were recruited
and both, total and free plasma concentration of cisplatin
following long and short durations of intravenous infusion was
determined. Blood samples were collected at 0.5, 1, 1.5, 2, 3
and 5 hours from the start of the infusion in the 1hour infusion
group and at 2, 3, 3.5, 4, 6 and 24 hours from the start of the
infusion, in the 3 hour infusion group. Total and free cisplatin
concentrations were measured using a validated HPLC-UV
method.
Results: The highest concentration of total and free cisplatin
was achieved at the end of the infusion in both regimens. Total
cisplatin concentration declined 30 minutes after the end of
infusion in both the groups. After 1hour of discontinuing cisplatin,
the free cisplatin concentration also declined significantly.
Conclusion: We conclude that radiation should be administered
within 30 minutes of completion of the infusion irrespective of
the duration of infusion. |
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| ISSN: | 2249-782X 0973-709X |