Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma
Abstract Current data advocate that oropharyngeal squamous cell carcinoma (OPSCC) should be divided into subsites when evaluating the presence of human papillomavirus (HPV) and prognosis. More specifically, tonsillar squamous cell carcinoma (TSCC) and base of tongue squamous cell carcinoma (BOTSCC)...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-05-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.1400 |
| _version_ | 1811154938879803392 |
|---|---|
| author | Linnea Haeggblom Tove Attoff Lalle Hammarstedt‐Nordenvall Anders Näsman |
| author_facet | Linnea Haeggblom Tove Attoff Lalle Hammarstedt‐Nordenvall Anders Näsman |
| author_sort | Linnea Haeggblom |
| collection | DOAJ |
| description | Abstract Current data advocate that oropharyngeal squamous cell carcinoma (OPSCC) should be divided into subsites when evaluating the presence of human papillomavirus (HPV) and prognosis. More specifically, tonsillar squamous cell carcinoma (TSCC) and base of tongue squamous cell carcinoma (BOTSCC) have much higher HPV prevalence compared to other OPSCC. Moreover, patients with HPV positive (HPV+) TSCC and BOTSCC have a better prognosis as compared to patients with HPV negative (HPV−) corresponding tumors, while the prognostic role of HPV in other OPSCC is unclear. Furthermore, in a recent report from Denmark, TSCC was further subclassified into specified TSCC (STSCC) and nonspecified TSCC (NSTSCC), with HPV significantly more prevalent in STSCC. In this study, the histopathological influence of HPV prevalence and survival in TSCC was analyzed in a TSCC cohort with known HPV status, of patients diagnosed 1970–2002 in Stockholm. In total, 139 TSCC biopsies with both tumor and adjacent normal tissue were separated into STSCC and NSTSCC. HPV was significantly more commonly found in STSCC than in NSTSCC. Patients with HPV+ STSCC had a better disease‐specific and overall survival as compared to patients with HPV+ NSTSCC, but no survival differences were observed in patients with HPV− STSCC and NSTCC. These findings confirm previous reports and suggest that TSCC subsite may also be of relevance for clinical outcome and should be further followed up in future studies. |
| first_indexed | 2024-04-10T04:24:33Z |
| format | Article |
| id | doaj.art-007479cb4061456281823134037c1d73 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-10T04:24:33Z |
| publishDate | 2018-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-007479cb4061456281823134037c1d732023-03-10T15:42:21ZengWileyCancer Medicine2045-76342018-05-01751717172210.1002/cam4.1400Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinomaLinnea Haeggblom0Tove Attoff1Lalle Hammarstedt‐Nordenvall2Anders Näsman3Department of Oncology‐Pathology Karolinska Institutet 171 76 Stockholm SwedenDepartment of Oncology‐Pathology Karolinska Institutet 171 76 Stockholm SwedenDepartment of Oto‐Rhino‐Laryngology, Head and Neck Surgery Karolinska University Hospital 171 76 Stockholm SwedenDepartment of Oncology‐Pathology Karolinska Institutet 171 76 Stockholm SwedenAbstract Current data advocate that oropharyngeal squamous cell carcinoma (OPSCC) should be divided into subsites when evaluating the presence of human papillomavirus (HPV) and prognosis. More specifically, tonsillar squamous cell carcinoma (TSCC) and base of tongue squamous cell carcinoma (BOTSCC) have much higher HPV prevalence compared to other OPSCC. Moreover, patients with HPV positive (HPV+) TSCC and BOTSCC have a better prognosis as compared to patients with HPV negative (HPV−) corresponding tumors, while the prognostic role of HPV in other OPSCC is unclear. Furthermore, in a recent report from Denmark, TSCC was further subclassified into specified TSCC (STSCC) and nonspecified TSCC (NSTSCC), with HPV significantly more prevalent in STSCC. In this study, the histopathological influence of HPV prevalence and survival in TSCC was analyzed in a TSCC cohort with known HPV status, of patients diagnosed 1970–2002 in Stockholm. In total, 139 TSCC biopsies with both tumor and adjacent normal tissue were separated into STSCC and NSTSCC. HPV was significantly more commonly found in STSCC than in NSTSCC. Patients with HPV+ STSCC had a better disease‐specific and overall survival as compared to patients with HPV+ NSTSCC, but no survival differences were observed in patients with HPV− STSCC and NSTCC. These findings confirm previous reports and suggest that TSCC subsite may also be of relevance for clinical outcome and should be further followed up in future studies.https://doi.org/10.1002/cam4.1400Human papillomavirusoropharyngeal cancersurvivaltonsillar cancer |
| spellingShingle | Linnea Haeggblom Tove Attoff Lalle Hammarstedt‐Nordenvall Anders Näsman Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma Cancer Medicine Human papillomavirus oropharyngeal cancer survival tonsillar cancer |
| title | Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma |
| title_full | Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma |
| title_fullStr | Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma |
| title_full_unstemmed | Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma |
| title_short | Human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma |
| title_sort | human papillomavirus and survival of patients per histological subsite of tonsillar squamous cell carcinoma |
| topic | Human papillomavirus oropharyngeal cancer survival tonsillar cancer |
| url | https://doi.org/10.1002/cam4.1400 |
| work_keys_str_mv | AT linneahaeggblom humanpapillomavirusandsurvivalofpatientsperhistologicalsubsiteoftonsillarsquamouscellcarcinoma AT toveattoff humanpapillomavirusandsurvivalofpatientsperhistologicalsubsiteoftonsillarsquamouscellcarcinoma AT lallehammarstedtnordenvall humanpapillomavirusandsurvivalofpatientsperhistologicalsubsiteoftonsillarsquamouscellcarcinoma AT andersnasman humanpapillomavirusandsurvivalofpatientsperhistologicalsubsiteoftonsillarsquamouscellcarcinoma |