A Crosstalk between the Cannabinoid Receptors and Nociceptin Receptors in Colitis—Clinical Implications
Inflammatory bowel diseases (IBD) refer to a group of gastrointestinal (GI) disorders with complex pathogenesis characterized by chronic intestinal inflammation with a variety of symptoms. Cannabinoid and nociceptin opioid receptors (NOPs) and their ligands are widely distributed in the GI tract. Th...
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MDPI AG
2022-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/22/6675 |
| _version_ | 1797464939741315072 |
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| author | Maria Wołyniak Ewa Małecka-Wojciesko Marta Zielińska Adam Fabisiak |
| author_facet | Maria Wołyniak Ewa Małecka-Wojciesko Marta Zielińska Adam Fabisiak |
| author_sort | Maria Wołyniak |
| collection | DOAJ |
| description | Inflammatory bowel diseases (IBD) refer to a group of gastrointestinal (GI) disorders with complex pathogenesis characterized by chronic intestinal inflammation with a variety of symptoms. Cannabinoid and nociceptin opioid receptors (NOPs) and their ligands are widely distributed in the GI tract. The nociceptin opioid receptor is a newly discovered member of the opioid receptor family with unique characteristics. Both cannabinoid and NOP systems exhibit antinociceptive and anti-inflammatory activity and contribute to maintaining proper motility, secretion and absorption in the GI tract. Furthermore, they influence high and low voltage calcium channels, which play a crucial role in the processing of pain, and share at least two kinases mediating their action. Among them there is NF-κB, a key factor in the regulation of inflammatory processes. Therefore, based on functional similarities between cannabinoid and nociceptin receptors and the anti-inflammatory effects exerted by their ligands, there is a high likelihood that there is an interaction between cannabinoid receptors 1 and 2 and the nociceptin receptor in colitis. In this review, we discuss potential overlaps between these two systems on a molecular and functional level in intestinal inflammation to create the basis for novel treatments of IBD. |
| first_indexed | 2024-03-09T18:14:20Z |
| format | Article |
| id | doaj.art-0074c5b5fae34c8ebcb695f2fac3f885 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T18:14:20Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0074c5b5fae34c8ebcb695f2fac3f8852023-11-24T08:48:16ZengMDPI AGJournal of Clinical Medicine2077-03832022-11-011122667510.3390/jcm11226675A Crosstalk between the Cannabinoid Receptors and Nociceptin Receptors in Colitis—Clinical ImplicationsMaria Wołyniak0Ewa Małecka-Wojciesko1Marta Zielińska2Adam Fabisiak3Department of Digestive Tract Diseases, Faculty of Medicine, Medical University of Lodz, 90-153 Lodz, PolandDepartment of Digestive Tract Diseases, Faculty of Medicine, Medical University of Lodz, 90-153 Lodz, PolandDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, 92-215 Lodz, PolandDepartment of Digestive Tract Diseases, Faculty of Medicine, Medical University of Lodz, 90-153 Lodz, PolandInflammatory bowel diseases (IBD) refer to a group of gastrointestinal (GI) disorders with complex pathogenesis characterized by chronic intestinal inflammation with a variety of symptoms. Cannabinoid and nociceptin opioid receptors (NOPs) and their ligands are widely distributed in the GI tract. The nociceptin opioid receptor is a newly discovered member of the opioid receptor family with unique characteristics. Both cannabinoid and NOP systems exhibit antinociceptive and anti-inflammatory activity and contribute to maintaining proper motility, secretion and absorption in the GI tract. Furthermore, they influence high and low voltage calcium channels, which play a crucial role in the processing of pain, and share at least two kinases mediating their action. Among them there is NF-κB, a key factor in the regulation of inflammatory processes. Therefore, based on functional similarities between cannabinoid and nociceptin receptors and the anti-inflammatory effects exerted by their ligands, there is a high likelihood that there is an interaction between cannabinoid receptors 1 and 2 and the nociceptin receptor in colitis. In this review, we discuss potential overlaps between these two systems on a molecular and functional level in intestinal inflammation to create the basis for novel treatments of IBD.https://www.mdpi.com/2077-0383/11/22/6675nociceptin opioid receptorendocannabinoidcolitisinflammatory bowel diseasesinflammationnociception |
| spellingShingle | Maria Wołyniak Ewa Małecka-Wojciesko Marta Zielińska Adam Fabisiak A Crosstalk between the Cannabinoid Receptors and Nociceptin Receptors in Colitis—Clinical Implications Journal of Clinical Medicine nociceptin opioid receptor endocannabinoid colitis inflammatory bowel diseases inflammation nociception |
| title | A Crosstalk between the Cannabinoid Receptors and Nociceptin Receptors in Colitis—Clinical Implications |
| title_full | A Crosstalk between the Cannabinoid Receptors and Nociceptin Receptors in Colitis—Clinical Implications |
| title_fullStr | A Crosstalk between the Cannabinoid Receptors and Nociceptin Receptors in Colitis—Clinical Implications |
| title_full_unstemmed | A Crosstalk between the Cannabinoid Receptors and Nociceptin Receptors in Colitis—Clinical Implications |
| title_short | A Crosstalk between the Cannabinoid Receptors and Nociceptin Receptors in Colitis—Clinical Implications |
| title_sort | crosstalk between the cannabinoid receptors and nociceptin receptors in colitis clinical implications |
| topic | nociceptin opioid receptor endocannabinoid colitis inflammatory bowel diseases inflammation nociception |
| url | https://www.mdpi.com/2077-0383/11/22/6675 |
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