Lung Cancer Screening With Low-dose Chest Computed Tomography: Experience From Radon-contaminated Regions in Kazakhstan
Objectives The aim of this study was to present the baseline results of a pilot project conducted to evaluate the effectiveness of lung cancer screening using low-dose chest computed tomography (CT) in regions with excessive radon levels in the Republic of Kazakhstan. Methods In total, 3671 particip...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Preventive Medicine
2022-05-01
|
| Series: | Journal of Preventive Medicine and Public Health |
| Subjects: | |
| Online Access: | http://jpmph.org/upload/pdf/jpmph-21-600.pdf |
| _version_ | 1817969545444327424 |
|---|---|
| author | Alexandra Panina Dilyara Kaidarova Zhamilya Zholdybay Akmaral Ainakulova Jandos Amankulov Dias Toleshbayev Zhanar Zhakenova Arman Khozhayev |
| author_facet | Alexandra Panina Dilyara Kaidarova Zhamilya Zholdybay Akmaral Ainakulova Jandos Amankulov Dias Toleshbayev Zhanar Zhakenova Arman Khozhayev |
| author_sort | Alexandra Panina |
| collection | DOAJ |
| description | Objectives The aim of this study was to present the baseline results of a pilot project conducted to evaluate the effectiveness of lung cancer screening using low-dose chest computed tomography (CT) in regions with excessive radon levels in the Republic of Kazakhstan. Methods In total, 3671 participants were screened by low-dose chest CT. Current, former, and never-smokers who resided in regions with elevated levels of radon in drinking water sources and indoor air, aged between 40 and 75 with no history of any cancer, and weighing less than 140 kg were included in the study. All lung nodules were categorized according to the American College of Radiology Lung Imaging Reporting and Data System (Lung-RADS 1.0). Results Overall, 614 (16.7%) participants had positive baseline CT findings (Lung-RADS categories 3 and 4). Seventy-four cancers were detected, yielding an overall cancer detection rate of 2.0%, with 10.8% (8/74) stage I and a predominance of stage III (59.4%; 44/74). Women never-smokers and men current smokers had the highest cancer detection rates, at 2.9% (12/412) and 6.1% (12/196), respectively. Compared to never-smokers, higher odds ratios (ORs) of lung cancer detection were found in smokers (OR,2.48; 95% confidence interval [CI], 1.52 to 4.05, p<0.001) and former smokers (OR, 2.32; 95% CI, 1.06 to 5.06, p=0.003). The most common histologic type of cancer was adenocarcinoma (58.1%). Conclusions Implementation of low-dose CT screening for lung cancer in regions with elevated radon levels is an effective method for both smokers and never-smokers. |
| first_indexed | 2024-04-13T20:22:29Z |
| format | Article |
| id | doaj.art-00754487912e48209e927b9cbaa9c2bc |
| institution | Directory Open Access Journal |
| issn | 1975-8375 2233-4521 |
| language | English |
| last_indexed | 2024-04-13T20:22:29Z |
| publishDate | 2022-05-01 |
| publisher | Korean Society for Preventive Medicine |
| record_format | Article |
| series | Journal of Preventive Medicine and Public Health |
| spelling | doaj.art-00754487912e48209e927b9cbaa9c2bc2022-12-22T02:31:30ZengKorean Society for Preventive MedicineJournal of Preventive Medicine and Public Health1975-83752233-45212022-05-0155327327910.3961/jpmph.21.6002207Lung Cancer Screening With Low-dose Chest Computed Tomography: Experience From Radon-contaminated Regions in KazakhstanAlexandra Panina0Dilyara Kaidarova1Zhamilya Zholdybay2Akmaral Ainakulova3Jandos Amankulov4Dias Toleshbayev5Zhanar Zhakenova6Arman Khozhayev7 Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan Asfendiyarov Kazakh National Medical University, Almaty, KazakhstanObjectives The aim of this study was to present the baseline results of a pilot project conducted to evaluate the effectiveness of lung cancer screening using low-dose chest computed tomography (CT) in regions with excessive radon levels in the Republic of Kazakhstan. Methods In total, 3671 participants were screened by low-dose chest CT. Current, former, and never-smokers who resided in regions with elevated levels of radon in drinking water sources and indoor air, aged between 40 and 75 with no history of any cancer, and weighing less than 140 kg were included in the study. All lung nodules were categorized according to the American College of Radiology Lung Imaging Reporting and Data System (Lung-RADS 1.0). Results Overall, 614 (16.7%) participants had positive baseline CT findings (Lung-RADS categories 3 and 4). Seventy-four cancers were detected, yielding an overall cancer detection rate of 2.0%, with 10.8% (8/74) stage I and a predominance of stage III (59.4%; 44/74). Women never-smokers and men current smokers had the highest cancer detection rates, at 2.9% (12/412) and 6.1% (12/196), respectively. Compared to never-smokers, higher odds ratios (ORs) of lung cancer detection were found in smokers (OR,2.48; 95% confidence interval [CI], 1.52 to 4.05, p<0.001) and former smokers (OR, 2.32; 95% CI, 1.06 to 5.06, p=0.003). The most common histologic type of cancer was adenocarcinoma (58.1%). Conclusions Implementation of low-dose CT screening for lung cancer in regions with elevated radon levels is an effective method for both smokers and never-smokers.http://jpmph.org/upload/pdf/jpmph-21-600.pdflung neoplasmsradonmass screeningkazakhstan |
| spellingShingle | Alexandra Panina Dilyara Kaidarova Zhamilya Zholdybay Akmaral Ainakulova Jandos Amankulov Dias Toleshbayev Zhanar Zhakenova Arman Khozhayev Lung Cancer Screening With Low-dose Chest Computed Tomography: Experience From Radon-contaminated Regions in Kazakhstan Journal of Preventive Medicine and Public Health lung neoplasms radon mass screening kazakhstan |
| title | Lung Cancer Screening With Low-dose Chest Computed Tomography: Experience From Radon-contaminated Regions in Kazakhstan |
| title_full | Lung Cancer Screening With Low-dose Chest Computed Tomography: Experience From Radon-contaminated Regions in Kazakhstan |
| title_fullStr | Lung Cancer Screening With Low-dose Chest Computed Tomography: Experience From Radon-contaminated Regions in Kazakhstan |
| title_full_unstemmed | Lung Cancer Screening With Low-dose Chest Computed Tomography: Experience From Radon-contaminated Regions in Kazakhstan |
| title_short | Lung Cancer Screening With Low-dose Chest Computed Tomography: Experience From Radon-contaminated Regions in Kazakhstan |
| title_sort | lung cancer screening with low dose chest computed tomography experience from radon contaminated regions in kazakhstan |
| topic | lung neoplasms radon mass screening kazakhstan |
| url | http://jpmph.org/upload/pdf/jpmph-21-600.pdf |
| work_keys_str_mv | AT alexandrapanina lungcancerscreeningwithlowdosechestcomputedtomographyexperiencefromradoncontaminatedregionsinkazakhstan AT dilyarakaidarova lungcancerscreeningwithlowdosechestcomputedtomographyexperiencefromradoncontaminatedregionsinkazakhstan AT zhamilyazholdybay lungcancerscreeningwithlowdosechestcomputedtomographyexperiencefromradoncontaminatedregionsinkazakhstan AT akmaralainakulova lungcancerscreeningwithlowdosechestcomputedtomographyexperiencefromradoncontaminatedregionsinkazakhstan AT jandosamankulov lungcancerscreeningwithlowdosechestcomputedtomographyexperiencefromradoncontaminatedregionsinkazakhstan AT diastoleshbayev lungcancerscreeningwithlowdosechestcomputedtomographyexperiencefromradoncontaminatedregionsinkazakhstan AT zhanarzhakenova lungcancerscreeningwithlowdosechestcomputedtomographyexperiencefromradoncontaminatedregionsinkazakhstan AT armankhozhayev lungcancerscreeningwithlowdosechestcomputedtomographyexperiencefromradoncontaminatedregionsinkazakhstan |