Cutaneous drug hypersensitivity : Immunological and genetic perspective
Drug hypersensitivity is an unpredictable, immunologically mediated adverse reaction, clustered in a genetically predisposed individual. The role of "hapten concept" in immune sensitization has recently been contested by the "pharmacological interaction" hypothesis. After complet...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2011;volume=56;issue=2;spage=137;epage=144;aulast=Ghosh |
| _version_ | 1828267887216820224 |
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| author | Kisalay Ghosh Gautam Banerjee Asok Kumar Ghosal Jayoti Nandi |
| author_facet | Kisalay Ghosh Gautam Banerjee Asok Kumar Ghosal Jayoti Nandi |
| author_sort | Kisalay Ghosh |
| collection | DOAJ |
| description | Drug hypersensitivity is an unpredictable, immunologically mediated adverse reaction, clustered in a genetically predisposed individual. The role of "hapten concept" in immune sensitization has recently been contested by the "pharmacological interaction" hypothesis. After completion of the "human genome project" and with the availability of high-resolution genotyping, genetic susceptibility to hypersensitivity for certain drugs has been proved beyond doubt though the trend is ethnicity and phenotype dependent. Application of this newly acquired knowledge may reduce or abolish the morbidity and mortality associated with cutaneous drug hypersensitivity. |
| first_indexed | 2024-04-13T05:10:38Z |
| format | Article |
| id | doaj.art-0075cc4837004feeba5d8275876b513f |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-04-13T05:10:38Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-0075cc4837004feeba5d8275876b513f2022-12-22T03:01:02ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112011-01-0156213714410.4103/0019-5154.80402Cutaneous drug hypersensitivity : Immunological and genetic perspectiveKisalay GhoshGautam BanerjeeAsok Kumar GhosalJayoti NandiDrug hypersensitivity is an unpredictable, immunologically mediated adverse reaction, clustered in a genetically predisposed individual. The role of "hapten concept" in immune sensitization has recently been contested by the "pharmacological interaction" hypothesis. After completion of the "human genome project" and with the availability of high-resolution genotyping, genetic susceptibility to hypersensitivity for certain drugs has been proved beyond doubt though the trend is ethnicity and phenotype dependent. Application of this newly acquired knowledge may reduce or abolish the morbidity and mortality associated with cutaneous drug hypersensitivity.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2011;volume=56;issue=2;spage=137;epage=144;aulast=GhoshCutaneous drug hypersensitivitydanger signalethnicityhaptenlinkage disequilibriummajor histocompatibility complexpharmacogenomicspharmacological interaction |
| spellingShingle | Kisalay Ghosh Gautam Banerjee Asok Kumar Ghosal Jayoti Nandi Cutaneous drug hypersensitivity : Immunological and genetic perspective Indian Journal of Dermatology Cutaneous drug hypersensitivity danger signal ethnicity hapten linkage disequilibrium major histocompatibility complex pharmacogenomics pharmacological interaction |
| title | Cutaneous drug hypersensitivity : Immunological and genetic perspective |
| title_full | Cutaneous drug hypersensitivity : Immunological and genetic perspective |
| title_fullStr | Cutaneous drug hypersensitivity : Immunological and genetic perspective |
| title_full_unstemmed | Cutaneous drug hypersensitivity : Immunological and genetic perspective |
| title_short | Cutaneous drug hypersensitivity : Immunological and genetic perspective |
| title_sort | cutaneous drug hypersensitivity immunological and genetic perspective |
| topic | Cutaneous drug hypersensitivity danger signal ethnicity hapten linkage disequilibrium major histocompatibility complex pharmacogenomics pharmacological interaction |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2011;volume=56;issue=2;spage=137;epage=144;aulast=Ghosh |
| work_keys_str_mv | AT kisalayghosh cutaneousdrughypersensitivityimmunologicalandgeneticperspective AT gautambanerjee cutaneousdrughypersensitivityimmunologicalandgeneticperspective AT asokkumarghosal cutaneousdrughypersensitivityimmunologicalandgeneticperspective AT jayotinandi cutaneousdrughypersensitivityimmunologicalandgeneticperspective |