Emerging applications of cancer bacteriotherapy towards treatment of pancreatic cancer
Pancreatic cancer is a highly aggressive form of cancer with a five-year survival rate of only ten percent. Pancreatic ductal adenocarcinoma (PDAC) accounts for ninety percent of those cases. PDAC is associated with a dense stroma that confers resistance to current treatment modalities. Increasing r...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1217095/full |
| _version_ | 1797768454645743616 |
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| author | Emily A. Henderson Slawomir Lukomski Slawomir Lukomski Brian A. Boone Brian A. Boone Brian A. Boone |
| author_facet | Emily A. Henderson Slawomir Lukomski Slawomir Lukomski Brian A. Boone Brian A. Boone Brian A. Boone |
| author_sort | Emily A. Henderson |
| collection | DOAJ |
| description | Pancreatic cancer is a highly aggressive form of cancer with a five-year survival rate of only ten percent. Pancreatic ductal adenocarcinoma (PDAC) accounts for ninety percent of those cases. PDAC is associated with a dense stroma that confers resistance to current treatment modalities. Increasing resistance to cancer treatments poses a challenge and a need for alternative therapies. Bacterial mediated cancer therapies were proposed in the late 1800s by Dr. William Coley when he injected osteosarcoma patients with live streptococci or a fabrication of heat-killed Streptococcus pyogenes and Serratia marcescens known as Coley’s toxin. Since then, several bacteria have gained recognition for possible roles in potentiating treatment response, enhancing anti-tumor immunity, and alleviating adverse effects to standard treatment options. This review highlights key bacterial mechanisms and structures that promote anti-tumor immunity, challenges and risks associated with bacterial mediated cancer therapies, and applications and opportunities for use in PDAC management. |
| first_indexed | 2024-03-12T20:54:08Z |
| format | Article |
| id | doaj.art-0076cc2628404b40905f55a8759dfaa0 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T20:54:08Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-0076cc2628404b40905f55a8759dfaa02023-07-31T21:47:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-07-011310.3389/fonc.2023.12170951217095Emerging applications of cancer bacteriotherapy towards treatment of pancreatic cancerEmily A. Henderson0Slawomir Lukomski1Slawomir Lukomski2Brian A. Boone3Brian A. Boone4Brian A. Boone5Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, United StatesDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, United StatesWest Virginia Cancer Institute, West Virginia University, Morgantown, WV, United StatesDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV, United StatesWest Virginia Cancer Institute, West Virginia University, Morgantown, WV, United StatesDepartment of Surgery, West Virginia University, Morgantown, WV, United StatesPancreatic cancer is a highly aggressive form of cancer with a five-year survival rate of only ten percent. Pancreatic ductal adenocarcinoma (PDAC) accounts for ninety percent of those cases. PDAC is associated with a dense stroma that confers resistance to current treatment modalities. Increasing resistance to cancer treatments poses a challenge and a need for alternative therapies. Bacterial mediated cancer therapies were proposed in the late 1800s by Dr. William Coley when he injected osteosarcoma patients with live streptococci or a fabrication of heat-killed Streptococcus pyogenes and Serratia marcescens known as Coley’s toxin. Since then, several bacteria have gained recognition for possible roles in potentiating treatment response, enhancing anti-tumor immunity, and alleviating adverse effects to standard treatment options. This review highlights key bacterial mechanisms and structures that promote anti-tumor immunity, challenges and risks associated with bacterial mediated cancer therapies, and applications and opportunities for use in PDAC management.https://www.frontiersin.org/articles/10.3389/fonc.2023.1217095/fullbacterial therapypancreatic ductal adenocarcinomaimmunotherapyanti-tumor immunitybioengineering |
| spellingShingle | Emily A. Henderson Slawomir Lukomski Slawomir Lukomski Brian A. Boone Brian A. Boone Brian A. Boone Emerging applications of cancer bacteriotherapy towards treatment of pancreatic cancer Frontiers in Oncology bacterial therapy pancreatic ductal adenocarcinoma immunotherapy anti-tumor immunity bioengineering |
| title | Emerging applications of cancer bacteriotherapy towards treatment of pancreatic cancer |
| title_full | Emerging applications of cancer bacteriotherapy towards treatment of pancreatic cancer |
| title_fullStr | Emerging applications of cancer bacteriotherapy towards treatment of pancreatic cancer |
| title_full_unstemmed | Emerging applications of cancer bacteriotherapy towards treatment of pancreatic cancer |
| title_short | Emerging applications of cancer bacteriotherapy towards treatment of pancreatic cancer |
| title_sort | emerging applications of cancer bacteriotherapy towards treatment of pancreatic cancer |
| topic | bacterial therapy pancreatic ductal adenocarcinoma immunotherapy anti-tumor immunity bioengineering |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1217095/full |
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