Predictors of persistent symptoms after mRNA SARS-CoV-2 vaccine-related myocarditis (myovacc registry)
AimsEpidemiological surveillance has raised safety concerns for mRNA SARS-CoV-2-vaccination-related myocarditis. We aimed to analyze epidemiological, clinical and imaging findings associated with clinical outcomes in these patients in an international multi-center registry (NCT05268458).Methods and...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1204232/full |
| _version_ | 1827919838088003584 |
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| author | Daniel Schroth Ria Garg Xhoi Bocova Jochen Hansmann Markus Haass Andrew Yan Carlos Fernando Binita Chacko Anastasia Oikonomou James White Muhammad Mustafa Alhussein Sorin Giusca Andreas Ochs Grigorios Korosoglou Florian André Matthias G. Friedrich Marco Ochs |
| author_facet | Daniel Schroth Ria Garg Xhoi Bocova Jochen Hansmann Markus Haass Andrew Yan Carlos Fernando Binita Chacko Anastasia Oikonomou James White Muhammad Mustafa Alhussein Sorin Giusca Andreas Ochs Grigorios Korosoglou Florian André Matthias G. Friedrich Marco Ochs |
| author_sort | Daniel Schroth |
| collection | DOAJ |
| description | AimsEpidemiological surveillance has raised safety concerns for mRNA SARS-CoV-2-vaccination-related myocarditis. We aimed to analyze epidemiological, clinical and imaging findings associated with clinical outcomes in these patients in an international multi-center registry (NCT05268458).Methods and resultsPatients with clinical and CMR diagnosis of acute myocarditis within 30 days after mRNA SARS-CoV-2—vaccination were included from five centers in Canada and Germany between 05/21 and 01/22. Clinical follow-up on persistent symptoms was collected. We enrolled 59 patients (80% males, mean age 29 years) with CMR-derived mild myocarditis (hs-Troponin-T 552 [249–1,193] ng/L, CRP 28 [13–51] mg/L; LVEF 57 ± 7%, LGE 3 [2–5] segments). Most common symptoms at baseline were chest pain (92%) and dyspnea (37%). Follow-up data from 50 patients showed overall symptomatic burden improvement. However, 12/50 patients (24%, 75% females, mean age 37 years) reported persisting symptoms (median interval 228 days) of chest pain (n = 8/12, 67%), dyspnea (n = 7/12, 58%), with increasing occurrence of fatigue (n = 5/12, 42%) and palpitations (n = 2/12, 17%). These patients had initial lower CRP, lower cardiac involvement in CMR, and fewer ECG changes. Significant predictors of persisting symptoms were female sex and dyspnea at initial presentation. Initial severity of myocarditis was not associated with persisting complaints.ConclusionA relevant proportion of patients with mRNA SARS-CoV-2-vaccination-related myocarditis report persisting complaints. While young males are usually affected, patients with persisting symptoms were predominantly females and older. The severity of the initial cardiac involvement not predicting these symptoms may suggest an extracardiac origin. |
| first_indexed | 2024-03-13T04:03:46Z |
| format | Article |
| id | doaj.art-00779fd8a8d44779a9f50f26603cd1de |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-13T04:03:46Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-00779fd8a8d44779a9f50f26603cd1de2023-06-21T09:52:20ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-06-011010.3389/fcvm.2023.12042321204232Predictors of persistent symptoms after mRNA SARS-CoV-2 vaccine-related myocarditis (myovacc registry)Daniel Schroth0Ria Garg1Xhoi Bocova2Jochen Hansmann3Markus Haass4Andrew Yan5Carlos Fernando6Binita Chacko7Anastasia Oikonomou8James White9Muhammad Mustafa Alhussein10Sorin Giusca11Andreas Ochs12Grigorios Korosoglou13Florian André14Matthias G. Friedrich15Marco Ochs16Departments of Radiology and Cardiology, Theresien Hospital, Mannheim, GermanyDepartments of Medicine and Diagnostic Radiology, McGill University Health Centre (MUHC), Montreal, QC, CanadaDepartments of Radiology and Cardiology, Theresien Hospital, Mannheim, GermanyDepartments of Radiology and Cardiology, Theresien Hospital, Mannheim, GermanyDepartments of Radiology and Cardiology, Theresien Hospital, Mannheim, GermanyDivision of Cardiology, Unity Health Toronto, St. Michael’s Hospital, Toronto, ON, CanadaDivision of Cardiology, Unity Health Toronto, St. Michael’s Hospital, Toronto, ON, CanadaDepartment of Medical Imaging, Sunnybrook Health Sciences Center, Toronto, ON, CanadaDepartment of Medical Imaging, Sunnybrook Health Sciences Center, Toronto, ON, CanadaStephenson Cardiac Imaging Centre, Foothills Medical Centre, Calgary, AB, CanadaStephenson Cardiac Imaging Centre, Foothills Medical Centre, Calgary, AB, CanadaDepartment of Cardiology, GRN Hospital, Weinheim, GermanyDepartment of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, GermanyDepartment of Cardiology, GRN Hospital, Weinheim, GermanyDepartment of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Heidelberg, GermanyDepartments of Medicine and Diagnostic Radiology, McGill University Health Centre (MUHC), Montreal, QC, CanadaDepartments of Radiology and Cardiology, Theresien Hospital, Mannheim, GermanyAimsEpidemiological surveillance has raised safety concerns for mRNA SARS-CoV-2-vaccination-related myocarditis. We aimed to analyze epidemiological, clinical and imaging findings associated with clinical outcomes in these patients in an international multi-center registry (NCT05268458).Methods and resultsPatients with clinical and CMR diagnosis of acute myocarditis within 30 days after mRNA SARS-CoV-2—vaccination were included from five centers in Canada and Germany between 05/21 and 01/22. Clinical follow-up on persistent symptoms was collected. We enrolled 59 patients (80% males, mean age 29 years) with CMR-derived mild myocarditis (hs-Troponin-T 552 [249–1,193] ng/L, CRP 28 [13–51] mg/L; LVEF 57 ± 7%, LGE 3 [2–5] segments). Most common symptoms at baseline were chest pain (92%) and dyspnea (37%). Follow-up data from 50 patients showed overall symptomatic burden improvement. However, 12/50 patients (24%, 75% females, mean age 37 years) reported persisting symptoms (median interval 228 days) of chest pain (n = 8/12, 67%), dyspnea (n = 7/12, 58%), with increasing occurrence of fatigue (n = 5/12, 42%) and palpitations (n = 2/12, 17%). These patients had initial lower CRP, lower cardiac involvement in CMR, and fewer ECG changes. Significant predictors of persisting symptoms were female sex and dyspnea at initial presentation. Initial severity of myocarditis was not associated with persisting complaints.ConclusionA relevant proportion of patients with mRNA SARS-CoV-2-vaccination-related myocarditis report persisting complaints. While young males are usually affected, patients with persisting symptoms were predominantly females and older. The severity of the initial cardiac involvement not predicting these symptoms may suggest an extracardiac origin.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1204232/fullcovid vaccinationmyocarditispersistent symptomspredictorsoutcome |
| spellingShingle | Daniel Schroth Ria Garg Xhoi Bocova Jochen Hansmann Markus Haass Andrew Yan Carlos Fernando Binita Chacko Anastasia Oikonomou James White Muhammad Mustafa Alhussein Sorin Giusca Andreas Ochs Grigorios Korosoglou Florian André Matthias G. Friedrich Marco Ochs Predictors of persistent symptoms after mRNA SARS-CoV-2 vaccine-related myocarditis (myovacc registry) Frontiers in Cardiovascular Medicine covid vaccination myocarditis persistent symptoms predictors outcome |
| title | Predictors of persistent symptoms after mRNA SARS-CoV-2 vaccine-related myocarditis (myovacc registry) |
| title_full | Predictors of persistent symptoms after mRNA SARS-CoV-2 vaccine-related myocarditis (myovacc registry) |
| title_fullStr | Predictors of persistent symptoms after mRNA SARS-CoV-2 vaccine-related myocarditis (myovacc registry) |
| title_full_unstemmed | Predictors of persistent symptoms after mRNA SARS-CoV-2 vaccine-related myocarditis (myovacc registry) |
| title_short | Predictors of persistent symptoms after mRNA SARS-CoV-2 vaccine-related myocarditis (myovacc registry) |
| title_sort | predictors of persistent symptoms after mrna sars cov 2 vaccine related myocarditis myovacc registry |
| topic | covid vaccination myocarditis persistent symptoms predictors outcome |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1204232/full |
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