Variability of adiposity indices and incident heart failure among adults with type 2 diabetes
Abstract Background It remains unclear how the variability of adiposity indices relates to incident HF. This study evaluated the associations of the variability in several adiposity indices with incident heart failure (HF) in individuals with type 2 diabetes (T2DM). Methods We included 4073 particip...
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-021-01440-1 |
| _version_ | 1818500887305256960 |
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| author | Arnaud D. Kaze Sebhat Erqou Prasanna Santhanam Alain G. Bertoni Rexford S. Ahima Gregg C. Fonarow Justin B. Echouffo-Tcheugui |
| author_facet | Arnaud D. Kaze Sebhat Erqou Prasanna Santhanam Alain G. Bertoni Rexford S. Ahima Gregg C. Fonarow Justin B. Echouffo-Tcheugui |
| author_sort | Arnaud D. Kaze |
| collection | DOAJ |
| description | Abstract Background It remains unclear how the variability of adiposity indices relates to incident HF. This study evaluated the associations of the variability in several adiposity indices with incident heart failure (HF) in individuals with type 2 diabetes (T2DM). Methods We included 4073 participants from the Look AHEAD (Action for Health in Diabetes) study. We assessed variability of body mass index (BMI), waist circumference (WC), and body weight across four annual visits using three variability metrics, the variability independent of the mean (VIM), coefficient of variation (CV), and intraindividual standard deviation (SD). Multivariable Cox regression models were used to generate adjusted hazard ratios (aHR) and 95% confidence intervals (CI) for incident HF. Results Over a median of 6.7 years, 120 participants developed incident HF. After adjusting for relevant confounders including baseline adiposity levels, the aHR for the highest (Q4) versus lowest quartile (Q1) of VIM of BMI was 3.61 (95% CI 1.91–6.80). The corresponding aHRs for CV and SD of BMI were 2.48 (95% CI 1.36–4.53) and 2.88 (1.52–5.46), respectively. Regarding WC variability, the equivalent aHRs were 1.90 (95% CI 1.11–3.26), 1.79 (95% CI 1.07–3.01), and 1.73 (1.01–2.95) for Q4 versus Q1 of VIM, CV and SD of WC, respectively. Conclusions In a large sample of adults with T2DM, a greater variability of adiposity indices was associated with higher risks of incident HF, independently of traditional risk factors and baseline adiposity levels. Registration-URL: https://clinicaltrials.gov/ct2/show/NCT00000620 . |
| first_indexed | 2024-12-10T20:48:45Z |
| format | Article |
| id | doaj.art-0077d211155f498bbef9bd9fb7f8443b |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-10T20:48:45Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-0077d211155f498bbef9bd9fb7f8443b2022-12-22T01:34:10ZengBMCCardiovascular Diabetology1475-28402022-02-012111810.1186/s12933-021-01440-1Variability of adiposity indices and incident heart failure among adults with type 2 diabetesArnaud D. Kaze0Sebhat Erqou1Prasanna Santhanam2Alain G. Bertoni3Rexford S. Ahima4Gregg C. Fonarow5Justin B. Echouffo-Tcheugui6Department of Medicine, SOVAH HealthDepartment of Medicine, Division of Cardiology, Providence VA Medical Center and Alpert Medical School of Brown UniversityDepartment of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins University School of MedicineDepartment of Epidemiology and Prevention, Wake Forest School of MedicineDepartment of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins University School of MedicineAhmanson-UCLA Cardiomyopathy Center, Ronald Reagan UCLA Medical CenterDepartment of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins University School of MedicineAbstract Background It remains unclear how the variability of adiposity indices relates to incident HF. This study evaluated the associations of the variability in several adiposity indices with incident heart failure (HF) in individuals with type 2 diabetes (T2DM). Methods We included 4073 participants from the Look AHEAD (Action for Health in Diabetes) study. We assessed variability of body mass index (BMI), waist circumference (WC), and body weight across four annual visits using three variability metrics, the variability independent of the mean (VIM), coefficient of variation (CV), and intraindividual standard deviation (SD). Multivariable Cox regression models were used to generate adjusted hazard ratios (aHR) and 95% confidence intervals (CI) for incident HF. Results Over a median of 6.7 years, 120 participants developed incident HF. After adjusting for relevant confounders including baseline adiposity levels, the aHR for the highest (Q4) versus lowest quartile (Q1) of VIM of BMI was 3.61 (95% CI 1.91–6.80). The corresponding aHRs for CV and SD of BMI were 2.48 (95% CI 1.36–4.53) and 2.88 (1.52–5.46), respectively. Regarding WC variability, the equivalent aHRs were 1.90 (95% CI 1.11–3.26), 1.79 (95% CI 1.07–3.01), and 1.73 (1.01–2.95) for Q4 versus Q1 of VIM, CV and SD of WC, respectively. Conclusions In a large sample of adults with T2DM, a greater variability of adiposity indices was associated with higher risks of incident HF, independently of traditional risk factors and baseline adiposity levels. Registration-URL: https://clinicaltrials.gov/ct2/show/NCT00000620 .https://doi.org/10.1186/s12933-021-01440-1Cardiovascular diseaseObesityDiabetes, type 2EpidemiologyHeart failure |
| spellingShingle | Arnaud D. Kaze Sebhat Erqou Prasanna Santhanam Alain G. Bertoni Rexford S. Ahima Gregg C. Fonarow Justin B. Echouffo-Tcheugui Variability of adiposity indices and incident heart failure among adults with type 2 diabetes Cardiovascular Diabetology Cardiovascular disease Obesity Diabetes, type 2 Epidemiology Heart failure |
| title | Variability of adiposity indices and incident heart failure among adults with type 2 diabetes |
| title_full | Variability of adiposity indices and incident heart failure among adults with type 2 diabetes |
| title_fullStr | Variability of adiposity indices and incident heart failure among adults with type 2 diabetes |
| title_full_unstemmed | Variability of adiposity indices and incident heart failure among adults with type 2 diabetes |
| title_short | Variability of adiposity indices and incident heart failure among adults with type 2 diabetes |
| title_sort | variability of adiposity indices and incident heart failure among adults with type 2 diabetes |
| topic | Cardiovascular disease Obesity Diabetes, type 2 Epidemiology Heart failure |
| url | https://doi.org/10.1186/s12933-021-01440-1 |
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