Multiple myeloma with gangrene of all four extremities
Introduction: Multiple myeloma represents a malignant proliferation of plasma cells derived from a single clone and it results in bone pain or fracture, renal failure, susceptibility to infections, anemia, and hypercalcemia. The hyperviscosity syndrome is rare. Cryoglobulins are immunoglubulins that...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2009-03-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/205 |
| _version_ | 1797716629322203136 |
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| author | Mohammad reza Mortazavizadeh Mahmood Karimi Mahmood Akhavan Tafti Hossein Soleimani Salehabadi |
| author_facet | Mohammad reza Mortazavizadeh Mahmood Karimi Mahmood Akhavan Tafti Hossein Soleimani Salehabadi |
| author_sort | Mohammad reza Mortazavizadeh |
| collection | DOAJ |
| description | Introduction: Multiple myeloma represents a malignant proliferation of plasma cells derived from a single clone and it results in bone pain or fracture, renal failure, susceptibility to infections, anemia, and hypercalcemia. The hyperviscosity syndrome is rare. Cryoglobulins are immunoglubulins that precipitate in the cold temperature less than 37˚C. Monoclonal cryoglobulins are associated with a significant hematologic disorder and are often asymptomatic. We reported the second case of multiple myeloma with gangrene of all four extremities.
Case: The Patient was a 77 year-old farmer who was referred due to 2-weeks history of blue, cold and painful fingers spread to middle of forearms and forelegs which was accompanied by feet skin erosions, dark points on auricle and discoloration of nose tip. In physical examination, quadrigangrene associated with auricle and tip of nose ischemia was seen. Serum proteins electrophoresis demonstrated monoclonal gammopathy and serum was positive for cryoglobulin. Bone marrow study showed neoplastic plasma cells infiltration. The patient with cryoglobulinemia, based on multiple myeloma was treated. |
| first_indexed | 2024-03-12T08:25:20Z |
| format | Article |
| id | doaj.art-0078ca61a02c486cb13c0dcc331abfdb |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T08:25:20Z |
| publishDate | 2009-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-0078ca61a02c486cb13c0dcc331abfdb2023-09-02T18:08:11ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072009-03-0131Multiple myeloma with gangrene of all four extremitiesMohammad reza Mortazavizadeh0Mahmood Karimi1Mahmood Akhavan Tafti2Hossein Soleimani Salehabadi3Shaheed Sadoughi Hospital, Yazd University of Medical Sciences, Yazd, Iran.Shaheed Sadoughi Hospital, Yazd University of Medical Sciences, Yazd, Iran.Shaheed Sadoughi Hospital, Yazd University of Medical Sciences, Yazd, Iran.Shaheed Sadoughi Hospital, Yazd University of Medical Sciences, Yazd, Iran.Introduction: Multiple myeloma represents a malignant proliferation of plasma cells derived from a single clone and it results in bone pain or fracture, renal failure, susceptibility to infections, anemia, and hypercalcemia. The hyperviscosity syndrome is rare. Cryoglobulins are immunoglubulins that precipitate in the cold temperature less than 37˚C. Monoclonal cryoglobulins are associated with a significant hematologic disorder and are often asymptomatic. We reported the second case of multiple myeloma with gangrene of all four extremities. Case: The Patient was a 77 year-old farmer who was referred due to 2-weeks history of blue, cold and painful fingers spread to middle of forearms and forelegs which was accompanied by feet skin erosions, dark points on auricle and discoloration of nose tip. In physical examination, quadrigangrene associated with auricle and tip of nose ischemia was seen. Serum proteins electrophoresis demonstrated monoclonal gammopathy and serum was positive for cryoglobulin. Bone marrow study showed neoplastic plasma cells infiltration. The patient with cryoglobulinemia, based on multiple myeloma was treated.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/205Multiple myelomacryoglobulinemiagangrene |
| spellingShingle | Mohammad reza Mortazavizadeh Mahmood Karimi Mahmood Akhavan Tafti Hossein Soleimani Salehabadi Multiple myeloma with gangrene of all four extremities International Journal of Hematology-Oncology and Stem Cell Research Multiple myeloma cryoglobulinemia gangrene |
| title | Multiple myeloma with gangrene of all four extremities |
| title_full | Multiple myeloma with gangrene of all four extremities |
| title_fullStr | Multiple myeloma with gangrene of all four extremities |
| title_full_unstemmed | Multiple myeloma with gangrene of all four extremities |
| title_short | Multiple myeloma with gangrene of all four extremities |
| title_sort | multiple myeloma with gangrene of all four extremities |
| topic | Multiple myeloma cryoglobulinemia gangrene |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/205 |
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