Simulating Evaluation Method on Heating Performances of Magnetic Nanoparticles with Temperature-Dependent Heating Efficiencies in Tumor Hyperthermia
The magnetic nanoparticles (MNPs) with decreasing heating efficiency (characterized by specific loss power, <i>SLP</i>) with temperature increase, especially around the Curie temperature (<i>T</i><sub>C</sub>), are expected to realize the self-regulated temperatur...
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MDPI AG
2022-06-01
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| Series: | Magnetochemistry |
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| Online Access: | https://www.mdpi.com/2312-7481/8/6/63 |
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| author | Shuai-Wen Ding Cheng-Wei Wu Xiao-Gang Yu Chao Dai Wei Zhang Jian-Po Gong |
| author_facet | Shuai-Wen Ding Cheng-Wei Wu Xiao-Gang Yu Chao Dai Wei Zhang Jian-Po Gong |
| author_sort | Shuai-Wen Ding |
| collection | DOAJ |
| description | The magnetic nanoparticles (MNPs) with decreasing heating efficiency (characterized by specific loss power, <i>SLP</i>) with temperature increase, especially around the Curie temperature (<i>T</i><sub>C</sub>), are expected to realize the self-regulated temperature hyperthermia of the tumor. However, the actual decrease of the <i>SLP</i> is gradual, resulting in the deviation of self-regulated temperatures from the measured <i>T</i><sub>C</sub>. So far, no method is available for evaluating the heating performances of those MNPs. Here, by simulating the temperature-dependent <i>SLP</i>, the heating performances of MNPs are evaluated from three clinically concerning aspects: the capacity for effective heating, the temperature uniformity in the tumor, and the temperature stability under environmental changes such as MNP loss or tumor progression. The developed methods were applied to ZnCoCrFeO, Fe<sub>3</sub>O<sub>4</sub>, and <i>γ</i>-Fe<sub>2</sub>O<sub>3</sub> MNPs. It was found that the uniform temperature distribution relies on lowering the heating power in the inner regions of the tumor, and the stable control of temperature depends on the dynamic adaptation of the heating power to the tumor temperature change. The proposed method may be used to predict the heating ability of MNPs and help the selection of MNPs for hyperthermia. |
| first_indexed | 2024-03-09T23:13:18Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2312-7481 |
| language | English |
| last_indexed | 2024-03-09T23:13:18Z |
| publishDate | 2022-06-01 |
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| record_format | Article |
| series | Magnetochemistry |
| spelling | doaj.art-0079750af5d24b0498f0b63014b10f932023-11-23T17:40:15ZengMDPI AGMagnetochemistry2312-74812022-06-01866310.3390/magnetochemistry8060063Simulating Evaluation Method on Heating Performances of Magnetic Nanoparticles with Temperature-Dependent Heating Efficiencies in Tumor HyperthermiaShuai-Wen Ding0Cheng-Wei Wu1Xiao-Gang Yu2Chao Dai3Wei Zhang4Jian-Po Gong5State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, ChinaState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, ChinaState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, ChinaState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, ChinaState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, ChinaWeichai Ballard Hy-Energy Technologies Co., Ltd., Weifang 261061, ChinaThe magnetic nanoparticles (MNPs) with decreasing heating efficiency (characterized by specific loss power, <i>SLP</i>) with temperature increase, especially around the Curie temperature (<i>T</i><sub>C</sub>), are expected to realize the self-regulated temperature hyperthermia of the tumor. However, the actual decrease of the <i>SLP</i> is gradual, resulting in the deviation of self-regulated temperatures from the measured <i>T</i><sub>C</sub>. So far, no method is available for evaluating the heating performances of those MNPs. Here, by simulating the temperature-dependent <i>SLP</i>, the heating performances of MNPs are evaluated from three clinically concerning aspects: the capacity for effective heating, the temperature uniformity in the tumor, and the temperature stability under environmental changes such as MNP loss or tumor progression. The developed methods were applied to ZnCoCrFeO, Fe<sub>3</sub>O<sub>4</sub>, and <i>γ</i>-Fe<sub>2</sub>O<sub>3</sub> MNPs. It was found that the uniform temperature distribution relies on lowering the heating power in the inner regions of the tumor, and the stable control of temperature depends on the dynamic adaptation of the heating power to the tumor temperature change. The proposed method may be used to predict the heating ability of MNPs and help the selection of MNPs for hyperthermia.https://www.mdpi.com/2312-7481/8/6/63magnetic nanomaterialmagnetic nanoparticleself-regulating temperaturehyperthermianumerical simulation |
| spellingShingle | Shuai-Wen Ding Cheng-Wei Wu Xiao-Gang Yu Chao Dai Wei Zhang Jian-Po Gong Simulating Evaluation Method on Heating Performances of Magnetic Nanoparticles with Temperature-Dependent Heating Efficiencies in Tumor Hyperthermia Magnetochemistry magnetic nanomaterial magnetic nanoparticle self-regulating temperature hyperthermia numerical simulation |
| title | Simulating Evaluation Method on Heating Performances of Magnetic Nanoparticles with Temperature-Dependent Heating Efficiencies in Tumor Hyperthermia |
| title_full | Simulating Evaluation Method on Heating Performances of Magnetic Nanoparticles with Temperature-Dependent Heating Efficiencies in Tumor Hyperthermia |
| title_fullStr | Simulating Evaluation Method on Heating Performances of Magnetic Nanoparticles with Temperature-Dependent Heating Efficiencies in Tumor Hyperthermia |
| title_full_unstemmed | Simulating Evaluation Method on Heating Performances of Magnetic Nanoparticles with Temperature-Dependent Heating Efficiencies in Tumor Hyperthermia |
| title_short | Simulating Evaluation Method on Heating Performances of Magnetic Nanoparticles with Temperature-Dependent Heating Efficiencies in Tumor Hyperthermia |
| title_sort | simulating evaluation method on heating performances of magnetic nanoparticles with temperature dependent heating efficiencies in tumor hyperthermia |
| topic | magnetic nanomaterial magnetic nanoparticle self-regulating temperature hyperthermia numerical simulation |
| url | https://www.mdpi.com/2312-7481/8/6/63 |
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