P2X1 receptors and the endothelium
Adenosine triphosphate (ATP) is now established as a principle vaso-active mediator in the vasculature. Its actions on arteries are complex, and are mediated by the P2X and P2Y receptor families. It is generally accepted that ATP induces a bi-phasic response in arteries, inducing contraction via the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2005-03-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900019 |
| _version_ | 1797713255754366976 |
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| author | LS Harrington JA Mitchell |
| author_facet | LS Harrington JA Mitchell |
| author_sort | LS Harrington |
| collection | DOAJ |
| description | Adenosine triphosphate (ATP) is now established as a principle vaso-active mediator in the vasculature. Its actions on arteries are complex, and are mediated by the P2X and P2Y receptor families. It is generally accepted that ATP induces a bi-phasic response in arteries, inducing contraction via the P2X and P2Y receptors on the smooth muscle cells, and vasodilation via the actions of P2Y receptors located on the endothelium. However, a number of recent studies have placed P2X1 receptors on the endothelium of some arteries. The use of a specific P2X1 receptor ligand, <FONT FACE=Symbol>a, b</FONT> methylene ATP has demonstrated that P2X1 receptors also have a bi-functional role. The actions of ATP on P2X1 receptors is therefore dependant on its location, inducing contraction when located on the smooth muscle cells, and dilation when expressed on the endothelium, comparable to that of P2Y receptors. |
| first_indexed | 2024-03-12T07:33:43Z |
| format | Article |
| id | doaj.art-007cf712090745499aa94d7897983ddc |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T07:33:43Z |
| publishDate | 2005-03-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-007cf712090745499aa94d7897983ddc2023-09-02T21:33:30ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602005-03-0110011111210.1590/S0074-02762005000900019P2X1 receptors and the endotheliumLS HarringtonJA MitchellAdenosine triphosphate (ATP) is now established as a principle vaso-active mediator in the vasculature. Its actions on arteries are complex, and are mediated by the P2X and P2Y receptor families. It is generally accepted that ATP induces a bi-phasic response in arteries, inducing contraction via the P2X and P2Y receptors on the smooth muscle cells, and vasodilation via the actions of P2Y receptors located on the endothelium. However, a number of recent studies have placed P2X1 receptors on the endothelium of some arteries. The use of a specific P2X1 receptor ligand, <FONT FACE=Symbol>a, b</FONT> methylene ATP has demonstrated that P2X1 receptors also have a bi-functional role. The actions of ATP on P2X1 receptors is therefore dependant on its location, inducing contraction when located on the smooth muscle cells, and dilation when expressed on the endothelium, comparable to that of P2Y receptors.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900019P2X1 receptorendotheliumsmooth muscle cellsadenosine triphosphate |
| spellingShingle | LS Harrington JA Mitchell P2X1 receptors and the endothelium Memorias do Instituto Oswaldo Cruz P2X1 receptor endothelium smooth muscle cells adenosine triphosphate |
| title | P2X1 receptors and the endothelium |
| title_full | P2X1 receptors and the endothelium |
| title_fullStr | P2X1 receptors and the endothelium |
| title_full_unstemmed | P2X1 receptors and the endothelium |
| title_short | P2X1 receptors and the endothelium |
| title_sort | p2x1 receptors and the endothelium |
| topic | P2X1 receptor endothelium smooth muscle cells adenosine triphosphate |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900019 |
| work_keys_str_mv | AT lsharrington p2x1receptorsandtheendothelium AT jamitchell p2x1receptorsandtheendothelium |