Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol—A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling

Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol—A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling

The CB<sub>1</sub> cannabinoid receptor (CB<sub>1</sub>R) contains one of the longest N termini among class A G protein-coupled receptors. Mutagenesis studies suggest that the allosteric binding site of cannabidiol (CBD) involves residues from the N terminal domain. In order...

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Bibliographic Details
Main Authors: Jakub Jakowiecki, Renata Abel, Urszula Orzeł, Paweł Pasznik, Robert Preissner, Sławomir Filipek
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
CB1
cannabinoid receptor
GPCRs
allosteric modulation
CBD
THC
Online Access:https://www.mdpi.com/1420-3049/26/9/2456

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