Alterations of Iron Level in the Bilateral Basal Ganglia Region in Patients With Middle Cerebral Artery Occlusion
Background and Purpose: The purpose of this study was to explore the changes of iron level using quantitative susceptibility mapping (QSM) in the bilateral basal ganglia region in middle cerebral artery occlusion (MCAO) patients with long-term ischemia.Methods: Twenty-seven healthy controls and nine...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-01-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2020.608058/full |
| _version_ | 1831582046887084032 |
|---|---|
| author | Lei Du Lei Du Zifang Zhao Xiuxiu Liu Yue Chen Wenwen Gao Yige Wang Jian Liu Bing Liu Guolin Ma Guolin Ma |
| author_facet | Lei Du Lei Du Zifang Zhao Xiuxiu Liu Yue Chen Wenwen Gao Yige Wang Jian Liu Bing Liu Guolin Ma Guolin Ma |
| author_sort | Lei Du |
| collection | DOAJ |
| description | Background and Purpose: The purpose of this study was to explore the changes of iron level using quantitative susceptibility mapping (QSM) in the bilateral basal ganglia region in middle cerebral artery occlusion (MCAO) patients with long-term ischemia.Methods: Twenty-seven healthy controls and nine patients with MCAO were recruited, and their QSM images were obtained. The bilateral caudate nucleus (Cd), putamen (Pt), and globus pallidus (Gp) were selected as the regions of interest (ROIs). Susceptibility values of bilateral ROIs were calculated and compared between the affected side and unaffected side in patients with MCAO and between patients with MCAO and healthy controls. In addition, receiver operating characteristic (ROC) curves were performed to evaluate the diagnostic capability of susceptibility values in differentiating healthy controls and patients with MCAO by the area under the curve (AUC).Results: The susceptibility values of bilateral Cd were asymmetric in healthy controls; however, this asymmetry disappeared in patients with MCAO. In addition, compared with healthy controls, the average susceptibility values of the bilateral Pt in patients with MCAO were increased (P < 0.05), and the average susceptibility value of the bilateral Gp was decreased (P < 0.05). ROC curves showed that the susceptibility values of the Pt and Gp had a larger AUC (AUC = 0.700 and 0.889, respectively).Conclusion: As measured by QSM, the iron levels of the bilateral basal ganglia region were significantly changed in patients with MCAO. Iron dyshomeostasis in the basal ganglia region might be involved in the pathophysiological process of middle cerebral artery stenosis and occlusion. These findings may provide a novel insight to profoundly address the pathophysiological mechanisms of MCAO. |
| first_indexed | 2024-12-17T20:17:24Z |
| format | Article |
| id | doaj.art-007da9d133d34f36a4b06201967e3dce |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-17T20:17:24Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-007da9d133d34f36a4b06201967e3dce2022-12-21T21:34:02ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-01-011410.3389/fnins.2020.608058608058Alterations of Iron Level in the Bilateral Basal Ganglia Region in Patients With Middle Cerebral Artery OcclusionLei Du0Lei Du1Zifang Zhao2Xiuxiu Liu3Yue Chen4Wenwen Gao5Yige Wang6Jian Liu7Bing Liu8Guolin Ma9Guolin Ma10Department of Radiology, China-Japan Friendship Hospital, Beijing, ChinaGraduate School of Peking Union Medical College, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Anesthesiology, Peking University First Hospital, Peking University, Beijing, ChinaDepartment of Radiology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Radiology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Radiology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Radiology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Ultrasound Diagnosis, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Radiology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Radiology, China-Japan Friendship Hospital, Beijing, ChinaGraduate School of Peking Union Medical College, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaBackground and Purpose: The purpose of this study was to explore the changes of iron level using quantitative susceptibility mapping (QSM) in the bilateral basal ganglia region in middle cerebral artery occlusion (MCAO) patients with long-term ischemia.Methods: Twenty-seven healthy controls and nine patients with MCAO were recruited, and their QSM images were obtained. The bilateral caudate nucleus (Cd), putamen (Pt), and globus pallidus (Gp) were selected as the regions of interest (ROIs). Susceptibility values of bilateral ROIs were calculated and compared between the affected side and unaffected side in patients with MCAO and between patients with MCAO and healthy controls. In addition, receiver operating characteristic (ROC) curves were performed to evaluate the diagnostic capability of susceptibility values in differentiating healthy controls and patients with MCAO by the area under the curve (AUC).Results: The susceptibility values of bilateral Cd were asymmetric in healthy controls; however, this asymmetry disappeared in patients with MCAO. In addition, compared with healthy controls, the average susceptibility values of the bilateral Pt in patients with MCAO were increased (P < 0.05), and the average susceptibility value of the bilateral Gp was decreased (P < 0.05). ROC curves showed that the susceptibility values of the Pt and Gp had a larger AUC (AUC = 0.700 and 0.889, respectively).Conclusion: As measured by QSM, the iron levels of the bilateral basal ganglia region were significantly changed in patients with MCAO. Iron dyshomeostasis in the basal ganglia region might be involved in the pathophysiological process of middle cerebral artery stenosis and occlusion. These findings may provide a novel insight to profoundly address the pathophysiological mechanisms of MCAO.https://www.frontiersin.org/articles/10.3389/fnins.2020.608058/fullmiddle cerebral artery occlusionquantitative susceptibility mappingironsusceptibilitybasal ganglia region |
| spellingShingle | Lei Du Lei Du Zifang Zhao Xiuxiu Liu Yue Chen Wenwen Gao Yige Wang Jian Liu Bing Liu Guolin Ma Guolin Ma Alterations of Iron Level in the Bilateral Basal Ganglia Region in Patients With Middle Cerebral Artery Occlusion Frontiers in Neuroscience middle cerebral artery occlusion quantitative susceptibility mapping iron susceptibility basal ganglia region |
| title | Alterations of Iron Level in the Bilateral Basal Ganglia Region in Patients With Middle Cerebral Artery Occlusion |
| title_full | Alterations of Iron Level in the Bilateral Basal Ganglia Region in Patients With Middle Cerebral Artery Occlusion |
| title_fullStr | Alterations of Iron Level in the Bilateral Basal Ganglia Region in Patients With Middle Cerebral Artery Occlusion |
| title_full_unstemmed | Alterations of Iron Level in the Bilateral Basal Ganglia Region in Patients With Middle Cerebral Artery Occlusion |
| title_short | Alterations of Iron Level in the Bilateral Basal Ganglia Region in Patients With Middle Cerebral Artery Occlusion |
| title_sort | alterations of iron level in the bilateral basal ganglia region in patients with middle cerebral artery occlusion |
| topic | middle cerebral artery occlusion quantitative susceptibility mapping iron susceptibility basal ganglia region |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2020.608058/full |
| work_keys_str_mv | AT leidu alterationsofironlevelinthebilateralbasalgangliaregioninpatientswithmiddlecerebralarteryocclusion AT leidu alterationsofironlevelinthebilateralbasalgangliaregioninpatientswithmiddlecerebralarteryocclusion AT zifangzhao alterationsofironlevelinthebilateralbasalgangliaregioninpatientswithmiddlecerebralarteryocclusion AT xiuxiuliu alterationsofironlevelinthebilateralbasalgangliaregioninpatientswithmiddlecerebralarteryocclusion AT yuechen alterationsofironlevelinthebilateralbasalgangliaregioninpatientswithmiddlecerebralarteryocclusion AT wenwengao alterationsofironlevelinthebilateralbasalgangliaregioninpatientswithmiddlecerebralarteryocclusion AT yigewang alterationsofironlevelinthebilateralbasalgangliaregioninpatientswithmiddlecerebralarteryocclusion AT jianliu alterationsofironlevelinthebilateralbasalgangliaregioninpatientswithmiddlecerebralarteryocclusion AT bingliu alterationsofironlevelinthebilateralbasalgangliaregioninpatientswithmiddlecerebralarteryocclusion AT guolinma alterationsofironlevelinthebilateralbasalgangliaregioninpatientswithmiddlecerebralarteryocclusion AT guolinma alterationsofironlevelinthebilateralbasalgangliaregioninpatientswithmiddlecerebralarteryocclusion |