The Roles of Coenzyme A Binding Pocket Residues in Short and Medium Chain Acyl-CoA Synthetases

The Roles of Coenzyme A Binding Pocket Residues in Short and Medium Chain Acyl-CoA Synthetases

Short- and medium-chain acyl-CoA synthetases catalyze similar two-step reactions in which acyl substrate and ATP bind to form an enzyme-bound acyl-adenylate, then CoA binds for formation of the acyl-CoA product. We investigated the roles of active site residues in CoA binding in acetyl-CoA synthetas...

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Bibliographic Details
Main Authors: Yu Meng, Cheryl Ingram-Smith, Oly Ahmed, Kerry Smith
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Life
Subjects:
acetyl-CoA
coenzyme A
acetyl-CoA synthetase
acyl-CoA synthetase
methanoarchaea
Online Access:https://www.mdpi.com/2075-1729/13/8/1643

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