Diversity and evolution of drug resistance mechanisms in Mycobacterium tuberculosis
Mashael Al-Saeedi, Sahal Al-Hajoj Department of Infection and Immunity, Mycobacteriology Research Section, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia Abstract: Despite the efficacy of antibiotics to protect humankind against many deadly pathogens, such as Myco...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-10-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/diversity-and-evolution-of-drug-resistance-mechanisms-in-mycobacterium-peer-reviewed-article-IDR |
| _version_ | 1811259076793860096 |
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| author | Al-Saeedi M Al-Hajoj S |
| author_facet | Al-Saeedi M Al-Hajoj S |
| author_sort | Al-Saeedi M |
| collection | DOAJ |
| description | Mashael Al-Saeedi, Sahal Al-Hajoj Department of Infection and Immunity, Mycobacteriology Research Section, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia Abstract: Despite the efficacy of antibiotics to protect humankind against many deadly pathogens, such as Mycobacterium tuberculosis, nothing can prevent the emergence of drug-resistant strains. Several mechanisms facilitate drug resistance in M. tuberculosis including compensatory evolution, epistasis, clonal interference, cell wall integrity, efflux pumps, and target mimicry. In this study, we present recent findings relevant to these mechanisms, which can enable the discovery of new drug targets and subsequent development of novel drugs for treatment of drug-resistant M. tuberculosis. Keywords: Mycobacterium tuberculosis, antibiotic resistance, compensatory evolution, epistasis, efflux pumps, fitness cost |
| first_indexed | 2024-04-12T18:25:02Z |
| format | Article |
| id | doaj.art-00813caa66a74b338fa803ced273d039 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-12T18:25:02Z |
| publishDate | 2017-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-00813caa66a74b338fa803ced273d0392022-12-22T03:21:17ZengDove Medical PressInfection and Drug Resistance1178-69732017-10-01Volume 1033334235177Diversity and evolution of drug resistance mechanisms in Mycobacterium tuberculosisAl-Saeedi MAl-Hajoj SMashael Al-Saeedi, Sahal Al-Hajoj Department of Infection and Immunity, Mycobacteriology Research Section, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia Abstract: Despite the efficacy of antibiotics to protect humankind against many deadly pathogens, such as Mycobacterium tuberculosis, nothing can prevent the emergence of drug-resistant strains. Several mechanisms facilitate drug resistance in M. tuberculosis including compensatory evolution, epistasis, clonal interference, cell wall integrity, efflux pumps, and target mimicry. In this study, we present recent findings relevant to these mechanisms, which can enable the discovery of new drug targets and subsequent development of novel drugs for treatment of drug-resistant M. tuberculosis. Keywords: Mycobacterium tuberculosis, antibiotic resistance, compensatory evolution, epistasis, efflux pumps, fitness costhttps://www.dovepress.com/diversity-and-evolution-of-drug-resistance-mechanisms-in-mycobacterium-peer-reviewed-article-IDRMycobacterium tuberculosisAntibiotic resistanceCompensatory evolutionEpistasisEfflux pumpsFitness cost |
| spellingShingle | Al-Saeedi M Al-Hajoj S Diversity and evolution of drug resistance mechanisms in Mycobacterium tuberculosis Infection and Drug Resistance Mycobacterium tuberculosis Antibiotic resistance Compensatory evolution Epistasis Efflux pumps Fitness cost |
| title | Diversity and evolution of drug resistance mechanisms in Mycobacterium tuberculosis |
| title_full | Diversity and evolution of drug resistance mechanisms in Mycobacterium tuberculosis |
| title_fullStr | Diversity and evolution of drug resistance mechanisms in Mycobacterium tuberculosis |
| title_full_unstemmed | Diversity and evolution of drug resistance mechanisms in Mycobacterium tuberculosis |
| title_short | Diversity and evolution of drug resistance mechanisms in Mycobacterium tuberculosis |
| title_sort | diversity and evolution of drug resistance mechanisms in mycobacterium tuberculosis |
| topic | Mycobacterium tuberculosis Antibiotic resistance Compensatory evolution Epistasis Efflux pumps Fitness cost |
| url | https://www.dovepress.com/diversity-and-evolution-of-drug-resistance-mechanisms-in-mycobacterium-peer-reviewed-article-IDR |
| work_keys_str_mv | AT alsaeedim diversityandevolutionofdrugresistancemechanismsinmycobacteriumtuberculosis AT alhajojs diversityandevolutionofdrugresistancemechanismsinmycobacteriumtuberculosis |