Epigenetic effects toward new insights as potential therapeutic target in B-thalassemia

Epigenetic effects toward new insights as potential therapeutic target in B-thalassemia

Abstract Background Fetal hemoglobin (HbF) induction has shown promise for the treatment of β-hemoglobinopathies. HbF induction in β-thalassemia could overcome ineffective hematopoiesis and thus terminate transfusion dependency for formerly transfusion dependant patients. Several miRNAs have been fo...

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Bibliographic Details
Main Authors: Noha Hamdy Eltaweel, Ghada Youssef ElKamah, Rabab Khairat, Hanan Abd Elmawgoud Atia, Khalda S. Amr
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Journal of Genetic Engineering and Biotechnology
Subjects:
Thalassemia therapy
HbF induction
MicroRNA
miR-15a
miR-16-1
miR-96
Online Access:https://doi.org/10.1186/s43141-021-00138-x

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