Enhancement of Antitumor Vaccination by Targeting Dendritic Cell-Related IL-10
Understanding mechanisms associated to dendritic cell (DC) functions has allowed developing new antitumor therapeutic vaccination strategies. However, these vaccines have demonstrated limited clinical results. Although the low immunogenicity of tumor antigens used and the presence of tumor-associate...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01923/full |
| _version_ | 1811192567160635392 |
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| author | Diana Llopiz Diana Llopiz Marta Ruiz Marta Ruiz Leyre Silva Leyre Silva Pablo Sarobe Pablo Sarobe |
| author_facet | Diana Llopiz Diana Llopiz Marta Ruiz Marta Ruiz Leyre Silva Leyre Silva Pablo Sarobe Pablo Sarobe |
| author_sort | Diana Llopiz |
| collection | DOAJ |
| description | Understanding mechanisms associated to dendritic cell (DC) functions has allowed developing new antitumor therapeutic vaccination strategies. However, these vaccines have demonstrated limited clinical results. Although the low immunogenicity of tumor antigens used and the presence of tumor-associated suppressive factors may in part account for these results, intrinsic vaccine-related factors may also be involved. Vaccines modulate DC functions by inducing activating and inhibitory signals that determine ensuing T cell responses. In this mini review, we focus on IL-10, inhibitory cytokine induced in DC upon vaccination, which defines a suppressive cell subset, discussing its implications as a potential target in combined vaccination immunotherapies. |
| first_indexed | 2024-04-11T23:55:50Z |
| format | Article |
| id | doaj.art-0081d4676bc442c9838910660c2e8051 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T23:55:50Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0081d4676bc442c9838910660c2e80512022-12-22T03:56:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-09-01910.3389/fimmu.2018.01923410692Enhancement of Antitumor Vaccination by Targeting Dendritic Cell-Related IL-10Diana Llopiz0Diana Llopiz1Marta Ruiz2Marta Ruiz3Leyre Silva4Leyre Silva5Pablo Sarobe6Pablo Sarobe7Programa de Inmunología e Inmunoterapia, Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pamplona, SpainInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, SpainPrograma de Inmunología e Inmunoterapia, Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pamplona, SpainInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, SpainPrograma de Inmunología e Inmunoterapia, Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pamplona, SpainInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, SpainPrograma de Inmunología e Inmunoterapia, Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pamplona, SpainInstituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, SpainUnderstanding mechanisms associated to dendritic cell (DC) functions has allowed developing new antitumor therapeutic vaccination strategies. However, these vaccines have demonstrated limited clinical results. Although the low immunogenicity of tumor antigens used and the presence of tumor-associated suppressive factors may in part account for these results, intrinsic vaccine-related factors may also be involved. Vaccines modulate DC functions by inducing activating and inhibitory signals that determine ensuing T cell responses. In this mini review, we focus on IL-10, inhibitory cytokine induced in DC upon vaccination, which defines a suppressive cell subset, discussing its implications as a potential target in combined vaccination immunotherapies.https://www.frontiersin.org/article/10.3389/fimmu.2018.01923/fullantitumor therapeutic vaccinationdendritic cellsinterleukin 10immunosuppressive cellsPD-L1type I IFN |
| spellingShingle | Diana Llopiz Diana Llopiz Marta Ruiz Marta Ruiz Leyre Silva Leyre Silva Pablo Sarobe Pablo Sarobe Enhancement of Antitumor Vaccination by Targeting Dendritic Cell-Related IL-10 Frontiers in Immunology antitumor therapeutic vaccination dendritic cells interleukin 10 immunosuppressive cells PD-L1 type I IFN |
| title | Enhancement of Antitumor Vaccination by Targeting Dendritic Cell-Related IL-10 |
| title_full | Enhancement of Antitumor Vaccination by Targeting Dendritic Cell-Related IL-10 |
| title_fullStr | Enhancement of Antitumor Vaccination by Targeting Dendritic Cell-Related IL-10 |
| title_full_unstemmed | Enhancement of Antitumor Vaccination by Targeting Dendritic Cell-Related IL-10 |
| title_short | Enhancement of Antitumor Vaccination by Targeting Dendritic Cell-Related IL-10 |
| title_sort | enhancement of antitumor vaccination by targeting dendritic cell related il 10 |
| topic | antitumor therapeutic vaccination dendritic cells interleukin 10 immunosuppressive cells PD-L1 type I IFN |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.01923/full |
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