The association between Acinetobacter baumannii infections and the COVID-19 pandemic in an intensive care unit
Abstract We aimed to describe the increased rate of Acinetobacter baumannii infections during the COVID-19 pandemic and define its significance within the last five years. This study was performed in a tertiary hospital with 280 beds and included all patients infected with A. baumannii in the intens...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25493-8 |
| _version_ | 1811190442151116800 |
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| author | Jale Boral Zeliha Genç Fatihan Pınarlık Güz Ekinci Mert A. Kuskucu Pelin İrkören Mahir Kapmaz Süda Tekin Nahit Çakar Evren Şentürk Fatma Yurdakul Bilge Dikenelli Fusun Can Onder Ergonul |
| author_facet | Jale Boral Zeliha Genç Fatihan Pınarlık Güz Ekinci Mert A. Kuskucu Pelin İrkören Mahir Kapmaz Süda Tekin Nahit Çakar Evren Şentürk Fatma Yurdakul Bilge Dikenelli Fusun Can Onder Ergonul |
| author_sort | Jale Boral |
| collection | DOAJ |
| description | Abstract We aimed to describe the increased rate of Acinetobacter baumannii infections during the COVID-19 pandemic and define its significance within the last five years. This study was performed in a tertiary hospital with 280 beds and included all patients infected with A. baumannii in the intensive care unit between January 1, 2018, and June 30, 2022. A. baumannii-infected patients in the intensive care unit 27 months before the pandemic and 27 months during the pandemic were included. Pulsed-field gel electrophoresis was performed to assess clonal relatedness. The infection control measures were specified based on the findings and targeted elimination. In total, 5718 patients were admitted to the intensive care unit from January 1st, 2018, to June 30th, 2022. A. baumannii infection was detected in 81 patients. Compared to the pre-pandemic era, the rate of A. baumannii infection during the pandemic was 1.90 times higher (OR: 1.90, 95% CI: [1.197, 3.033]). Clonality assessment of multidrug-resistant A. baumannii samples revealed eight clusters with one main cluster comprising 14/27 isolates between 2021 and 2022. The case fatality rate of the pre-pandemic and pandemic era was not different statistically (83.33% vs. 81.48%, p = 0.835). Univariate analysis revealed the association of mechanical ventilation (p = 0.002) and bacterial growth in tracheal aspirate (p = 0.001) with fatality. During the COVID-19 pandemic, potential deficits in infection control measures may lead to persistent nosocomial outbreaks. In this study, the introduction of enhanced and customized infection control measures has resulted in the containment of an A. baumannii outbreak. |
| first_indexed | 2024-04-11T14:50:12Z |
| format | Article |
| id | doaj.art-008207f86a964b53b5bc62205473b1b7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T14:50:12Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-008207f86a964b53b5bc62205473b1b72022-12-22T04:17:28ZengNature PortfolioScientific Reports2045-23222022-12-011211710.1038/s41598-022-25493-8The association between Acinetobacter baumannii infections and the COVID-19 pandemic in an intensive care unitJale Boral0Zeliha Genç1Fatihan Pınarlık2Güz Ekinci3Mert A. Kuskucu4Pelin İrkören5Mahir Kapmaz6Süda Tekin7Nahit Çakar8Evren Şentürk9Fatma Yurdakul10Bilge Dikenelli11Fusun Can12Onder Ergonul13Graduate School of Health Sciences, Koç UniversityInfectious Diseases and Clinical Microbiology, Koç University HospitalGraduate School of Health Sciences, Koç UniversityGraduate School of Health Sciences, Koç UniversityKoç University İşBank Center for Infectious Diseases, Koç University HospitalInfectious Diseases and Clinical Microbiology, Koç University HospitalInfectious Diseases and Clinical Microbiology, Koç University HospitalDepartment of Infectious Diseases and Clinical Microbiology, School of Medicine, Koç UniversityDepartment of Anesthesiology and Reanimation, Koç University School of MedicineDepartment of Anesthesiology and Reanimation, Koç University School of MedicineDepartment of Anesthesiology and Reanimation, Koç University School of MedicineClinical Microbiology Laboratory, Koç University HospitalGraduate School of Health Sciences, Koç UniversityKoç University İşBank Center for Infectious Diseases, Koç University HospitalAbstract We aimed to describe the increased rate of Acinetobacter baumannii infections during the COVID-19 pandemic and define its significance within the last five years. This study was performed in a tertiary hospital with 280 beds and included all patients infected with A. baumannii in the intensive care unit between January 1, 2018, and June 30, 2022. A. baumannii-infected patients in the intensive care unit 27 months before the pandemic and 27 months during the pandemic were included. Pulsed-field gel electrophoresis was performed to assess clonal relatedness. The infection control measures were specified based on the findings and targeted elimination. In total, 5718 patients were admitted to the intensive care unit from January 1st, 2018, to June 30th, 2022. A. baumannii infection was detected in 81 patients. Compared to the pre-pandemic era, the rate of A. baumannii infection during the pandemic was 1.90 times higher (OR: 1.90, 95% CI: [1.197, 3.033]). Clonality assessment of multidrug-resistant A. baumannii samples revealed eight clusters with one main cluster comprising 14/27 isolates between 2021 and 2022. The case fatality rate of the pre-pandemic and pandemic era was not different statistically (83.33% vs. 81.48%, p = 0.835). Univariate analysis revealed the association of mechanical ventilation (p = 0.002) and bacterial growth in tracheal aspirate (p = 0.001) with fatality. During the COVID-19 pandemic, potential deficits in infection control measures may lead to persistent nosocomial outbreaks. In this study, the introduction of enhanced and customized infection control measures has resulted in the containment of an A. baumannii outbreak.https://doi.org/10.1038/s41598-022-25493-8 |
| spellingShingle | Jale Boral Zeliha Genç Fatihan Pınarlık Güz Ekinci Mert A. Kuskucu Pelin İrkören Mahir Kapmaz Süda Tekin Nahit Çakar Evren Şentürk Fatma Yurdakul Bilge Dikenelli Fusun Can Onder Ergonul The association between Acinetobacter baumannii infections and the COVID-19 pandemic in an intensive care unit Scientific Reports |
| title | The association between Acinetobacter baumannii infections and the COVID-19 pandemic in an intensive care unit |
| title_full | The association between Acinetobacter baumannii infections and the COVID-19 pandemic in an intensive care unit |
| title_fullStr | The association between Acinetobacter baumannii infections and the COVID-19 pandemic in an intensive care unit |
| title_full_unstemmed | The association between Acinetobacter baumannii infections and the COVID-19 pandemic in an intensive care unit |
| title_short | The association between Acinetobacter baumannii infections and the COVID-19 pandemic in an intensive care unit |
| title_sort | association between acinetobacter baumannii infections and the covid 19 pandemic in an intensive care unit |
| url | https://doi.org/10.1038/s41598-022-25493-8 |
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