Tomato Bushy Stunt Virus Nanoparticles as a Platform for Drug Delivery to Shh-Dependent Medulloblastoma

Tomato Bushy Stunt Virus Nanoparticles as a Platform for Drug Delivery to Shh-Dependent Medulloblastoma

Medulloblastoma (MB) is a primary central nervous system tumor affecting mainly young children. New strategies of drug delivery are urgent to treat MB and, in particular, the SHH-dependent subtype—the most common in infants—in whom radiotherapy is precluded due to the severe neurological side effect...

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Bibliographic Details
Main Authors: Chiara Lico, Barbara Tanno, Luca Marchetti, Flavia Novelli, Paola Giardullo, Caterina Arcangeli, Simonetta Pazzaglia, Maurizio S. Podda, Luca Santi, Roberta Bernini, Selene Baschieri, Mariateresa Mancuso
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
plant virus nanoparticles
tomato bushy stunt virus
medulloblastoma
targeting peptides
drug loading
molecular docking and simulation
Online Access:https://www.mdpi.com/1422-0067/22/19/10523

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