Glioma Mimics: Magnetic Resonance Imaging Characteristics of Granulomas in Dogs
Granulomas can “mimic” gliomas on magnetic resonance imaging (MRI) in human patients. The goal of this retrospective study was to report canine brain granulomas that were consistent with glioma based upon MRI, report their histologic diagnosis, and identify MRI criteria that might be useful to disti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fvets.2019.00286/full |
| _version_ | 1818096831672877056 |
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| author | Lauren Diangelo Aaron Cohen-Gadol Aaron Cohen-Gadol Hock Gan Heng Margaret A. Miller Devon W. Hague John H. Rossmeisl R. Timothy Bentley |
| author_facet | Lauren Diangelo Aaron Cohen-Gadol Aaron Cohen-Gadol Hock Gan Heng Margaret A. Miller Devon W. Hague John H. Rossmeisl R. Timothy Bentley |
| author_sort | Lauren Diangelo |
| collection | DOAJ |
| description | Granulomas can “mimic” gliomas on magnetic resonance imaging (MRI) in human patients. The goal of this retrospective study was to report canine brain granulomas that were consistent with glioma based upon MRI, report their histologic diagnosis, and identify MRI criteria that might be useful to distinguish granuloma from glioma. Ten granulomas, initially suspected to be glioma based on MRI, were ultimately diagnosed as granulomatous meningoencephalomyelitis (n = 5), infectious granulomas (n = 3) or other meningoencephalitis (n = 2). Age was 1.6–15.0 years and two dogs were brachycephalic breeds. MRI characteristics overlapping with glioma included intra-axial, heterogeneous, T2-weighted hyperintense, T1-weighted hypointense to isointense mass lesions with contrast-enhancement. Signals on fluid attenuation inversion recovery, gradient echo and diffusion weighted imaging also matched glioma. Peri-lesional edema and mass effect were toward the high end of findings reported for glioma. MRI characteristics that would be considered unusual for glioma included dural contact (n = 4), T2-hypointensity (n = 2), concomitant meningeal-enhancement (n = 9), and minor changes in the contralateral brain (n = 2). Cerebrospinal fluid analysis revealed albuminocytological dissociation or mild pleocytosis. These cases show that granulomas can “mimic” glioma on canine brain MRI. In individual cases, certain MRI findings may help increase the index of suspicion for granuloma. Lack of pronounced cerebrospinal fluid pleocytosis does not exclude granuloma. Signalment is very useful in the suspicion of glioma, and many of these dogs with granuloma were of ages and breeds in which glioma is less commonly seen. |
| first_indexed | 2024-12-10T23:10:53Z |
| format | Article |
| id | doaj.art-00827e856e0e44258bef1271942b5fc8 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-10T23:10:53Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-00827e856e0e44258bef1271942b5fc82022-12-22T01:29:57ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692019-08-01610.3389/fvets.2019.00286465748Glioma Mimics: Magnetic Resonance Imaging Characteristics of Granulomas in DogsLauren Diangelo0Aaron Cohen-Gadol1Aaron Cohen-Gadol2Hock Gan Heng3Margaret A. Miller4Devon W. Hague5John H. Rossmeisl6R. Timothy Bentley7Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, United StatesDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, United StatesDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, United StatesDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, United StatesDepartment of Comparative Pathobiology, Purdue University, West Lafayette, IN, United StatesDepartment of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL, United StatesDepartment of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, United StatesDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, United StatesGranulomas can “mimic” gliomas on magnetic resonance imaging (MRI) in human patients. The goal of this retrospective study was to report canine brain granulomas that were consistent with glioma based upon MRI, report their histologic diagnosis, and identify MRI criteria that might be useful to distinguish granuloma from glioma. Ten granulomas, initially suspected to be glioma based on MRI, were ultimately diagnosed as granulomatous meningoencephalomyelitis (n = 5), infectious granulomas (n = 3) or other meningoencephalitis (n = 2). Age was 1.6–15.0 years and two dogs were brachycephalic breeds. MRI characteristics overlapping with glioma included intra-axial, heterogeneous, T2-weighted hyperintense, T1-weighted hypointense to isointense mass lesions with contrast-enhancement. Signals on fluid attenuation inversion recovery, gradient echo and diffusion weighted imaging also matched glioma. Peri-lesional edema and mass effect were toward the high end of findings reported for glioma. MRI characteristics that would be considered unusual for glioma included dural contact (n = 4), T2-hypointensity (n = 2), concomitant meningeal-enhancement (n = 9), and minor changes in the contralateral brain (n = 2). Cerebrospinal fluid analysis revealed albuminocytological dissociation or mild pleocytosis. These cases show that granulomas can “mimic” glioma on canine brain MRI. In individual cases, certain MRI findings may help increase the index of suspicion for granuloma. Lack of pronounced cerebrospinal fluid pleocytosis does not exclude granuloma. Signalment is very useful in the suspicion of glioma, and many of these dogs with granuloma were of ages and breeds in which glioma is less commonly seen.https://www.frontiersin.org/article/10.3389/fvets.2019.00286/fullbraincaninefungalgranulomatous meningoencephalomyelitispseudotumor |
| spellingShingle | Lauren Diangelo Aaron Cohen-Gadol Aaron Cohen-Gadol Hock Gan Heng Margaret A. Miller Devon W. Hague John H. Rossmeisl R. Timothy Bentley Glioma Mimics: Magnetic Resonance Imaging Characteristics of Granulomas in Dogs Frontiers in Veterinary Science brain canine fungal granulomatous meningoencephalomyelitis pseudotumor |
| title | Glioma Mimics: Magnetic Resonance Imaging Characteristics of Granulomas in Dogs |
| title_full | Glioma Mimics: Magnetic Resonance Imaging Characteristics of Granulomas in Dogs |
| title_fullStr | Glioma Mimics: Magnetic Resonance Imaging Characteristics of Granulomas in Dogs |
| title_full_unstemmed | Glioma Mimics: Magnetic Resonance Imaging Characteristics of Granulomas in Dogs |
| title_short | Glioma Mimics: Magnetic Resonance Imaging Characteristics of Granulomas in Dogs |
| title_sort | glioma mimics magnetic resonance imaging characteristics of granulomas in dogs |
| topic | brain canine fungal granulomatous meningoencephalomyelitis pseudotumor |
| url | https://www.frontiersin.org/article/10.3389/fvets.2019.00286/full |
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