Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology

Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology

Brain morphology has been shown to be highly heritable, yet only a small portion of the heritability is explained by the genetic variants discovered so far. Here we extended the Multivariate Omnibus Statistical Test (MOSTest) and applied it to genome-wide association studies (GWAS) of vertex-wise st...

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Bibliographic Details
Main Authors: Alexey A. Shadrin, Tobias Kaufmann, Dennis van der Meer, Clare E. Palmer, Carolina Makowski, Robert Loughnan, Terry L. Jernigan, Tyler M. Seibert, Donald J Hagler, Olav B. Smeland, Ehsan Motazedi, Yunhan Chu, Aihua Lin, Weiqiu Cheng, Guy Hindley, Wesley K. Thompson, Chun C. Fan, Dominic Holland, Lars T. Westlye, Oleksandr Frei, Ole A. Andreassen, Anders M. Dale
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:NeuroImage
Subjects:
Multivariate vertex-wise analysis
Cortical surface area
Cortical thickness
Genome-wide association study
Distributed polygenic architecture
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811921008764

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