TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator
Transcription factor EB (TFEB) is considered the master transcriptional regulator of autophagy and lysosomal biogenesis, which regulates target gene expression through binding to CLEAR motifs. TFEB dysregulation has been linked to the development of numerous pathological conditions; however, several...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/19/3153 |
| _version_ | 1827654689656668160 |
|---|---|
| author | Berenice Franco-Juárez Cristina Coronel-Cruz Beatriz Hernández-Ochoa Saúl Gómez-Manzo Noemi Cárdenas-Rodríguez Roberto Arreguin-Espinosa Cindy Bandala Luis Miguel Canseco-Ávila Daniel Ortega-Cuellar |
| author_facet | Berenice Franco-Juárez Cristina Coronel-Cruz Beatriz Hernández-Ochoa Saúl Gómez-Manzo Noemi Cárdenas-Rodríguez Roberto Arreguin-Espinosa Cindy Bandala Luis Miguel Canseco-Ávila Daniel Ortega-Cuellar |
| author_sort | Berenice Franco-Juárez |
| collection | DOAJ |
| description | Transcription factor EB (TFEB) is considered the master transcriptional regulator of autophagy and lysosomal biogenesis, which regulates target gene expression through binding to CLEAR motifs. TFEB dysregulation has been linked to the development of numerous pathological conditions; however, several other lines of evidence show that TFEB might be a point of convergence of diverse signaling pathways and might therefore modulate other important biological processes such as cellular senescence, DNA repair, ER stress, carbohydrates, and lipid metabolism and WNT signaling-related processes. The regulation of TFEB occurs predominantly at the post-translational level, including phosphorylation, acetylation, SUMOylating, PARsylation, and glycosylation. It is noteworthy that TFEB activation is context-dependent; therefore, its regulation is subjected to coordinated mechanisms that respond not only to nutrient fluctuations but also to stress cell programs to ensure proper cell homeostasis and organismal health. In this review, we provide updated insights into novel post-translational modifications that regulate TFEB activity and give an overview of TFEB beyond its widely known role in autophagy and the lysosomal pathway, thus opening the possibility of considering TFEB as a potential therapeutic target. |
| first_indexed | 2024-03-09T21:52:25Z |
| format | Article |
| id | doaj.art-0086892a921940539eafbbee08a6ae5c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T21:52:25Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-0086892a921940539eafbbee08a6ae5c2023-11-23T20:03:42ZengMDPI AGCells2073-44092022-10-011119315310.3390/cells11193153TFEB; Beyond Its Role as an Autophagy and Lysosomes RegulatorBerenice Franco-Juárez0Cristina Coronel-Cruz1Beatriz Hernández-Ochoa2Saúl Gómez-Manzo3Noemi Cárdenas-Rodríguez4Roberto Arreguin-Espinosa5Cindy Bandala6Luis Miguel Canseco-Ávila7Daniel Ortega-Cuellar8Departamento de Neurodesarrollo y Fisiología, División de Neurociencias, Instituto de Fisiología Celular, UNAM, Mexico City 04510, MexicoDepartamento de Biología Celular y Tisular, Facultad de Medicina, UNAM, Mexico City 04510, MexicoLaboratorio de Inmunoquímica, Hospital Infantil de México Federico Gómez, Secretaría de Salud, Mexico City 06720, MexicoLaboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, MexicoLaboratorio de Neurociencias, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, MexicoDepartamento de Química de Biomacromoléculas, Instituto de Química, Universidad Nacional Autónoma de Mexico, Mexico City 04510, MexicoEscuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, MexicoFacultad de Ciencias Químicas, Campus IV, Universidad Autónoma de Chiapas, Tapachula Chiapas 30700, MexicoLaboratorio de Nutrición Experimental, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, MexicoTranscription factor EB (TFEB) is considered the master transcriptional regulator of autophagy and lysosomal biogenesis, which regulates target gene expression through binding to CLEAR motifs. TFEB dysregulation has been linked to the development of numerous pathological conditions; however, several other lines of evidence show that TFEB might be a point of convergence of diverse signaling pathways and might therefore modulate other important biological processes such as cellular senescence, DNA repair, ER stress, carbohydrates, and lipid metabolism and WNT signaling-related processes. The regulation of TFEB occurs predominantly at the post-translational level, including phosphorylation, acetylation, SUMOylating, PARsylation, and glycosylation. It is noteworthy that TFEB activation is context-dependent; therefore, its regulation is subjected to coordinated mechanisms that respond not only to nutrient fluctuations but also to stress cell programs to ensure proper cell homeostasis and organismal health. In this review, we provide updated insights into novel post-translational modifications that regulate TFEB activity and give an overview of TFEB beyond its widely known role in autophagy and the lysosomal pathway, thus opening the possibility of considering TFEB as a potential therapeutic target.https://www.mdpi.com/2073-4409/11/19/3153transcriptional factor EB (TFEB)cellular senescenceDNA damage repair and cell cycleWNT signalingendoplasmic reticulum stresscarbohydrate |
| spellingShingle | Berenice Franco-Juárez Cristina Coronel-Cruz Beatriz Hernández-Ochoa Saúl Gómez-Manzo Noemi Cárdenas-Rodríguez Roberto Arreguin-Espinosa Cindy Bandala Luis Miguel Canseco-Ávila Daniel Ortega-Cuellar TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator Cells transcriptional factor EB (TFEB) cellular senescence DNA damage repair and cell cycle WNT signaling endoplasmic reticulum stress carbohydrate |
| title | TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator |
| title_full | TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator |
| title_fullStr | TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator |
| title_full_unstemmed | TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator |
| title_short | TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator |
| title_sort | tfeb beyond its role as an autophagy and lysosomes regulator |
| topic | transcriptional factor EB (TFEB) cellular senescence DNA damage repair and cell cycle WNT signaling endoplasmic reticulum stress carbohydrate |
| url | https://www.mdpi.com/2073-4409/11/19/3153 |
| work_keys_str_mv | AT berenicefrancojuarez tfebbeyonditsroleasanautophagyandlysosomesregulator AT cristinacoronelcruz tfebbeyonditsroleasanautophagyandlysosomesregulator AT beatrizhernandezochoa tfebbeyonditsroleasanautophagyandlysosomesregulator AT saulgomezmanzo tfebbeyonditsroleasanautophagyandlysosomesregulator AT noemicardenasrodriguez tfebbeyonditsroleasanautophagyandlysosomesregulator AT robertoarreguinespinosa tfebbeyonditsroleasanautophagyandlysosomesregulator AT cindybandala tfebbeyonditsroleasanautophagyandlysosomesregulator AT luismiguelcansecoavila tfebbeyonditsroleasanautophagyandlysosomesregulator AT danielortegacuellar tfebbeyonditsroleasanautophagyandlysosomesregulator |