Formation and characterization of zein electrosprayed nanoparticles containing bioactive compounds
The objective of this work is to investigate the nanoencapsulation of valuable bioactive compounds with the innovative electrohydrodynamic technology. More specifically, electrospraying, was applied for the encapsulation of three different active agents with lipolytic, anti-aging and antioxidant act...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-04-01
|
| Series: | South African Journal of Chemical Engineering |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1026918522000051 |
| _version_ | 1811260526864367616 |
|---|---|
| author | Margarita Panagiotopoulou Sofia Papadaki Magdalini Krokida |
| author_facet | Margarita Panagiotopoulou Sofia Papadaki Magdalini Krokida |
| author_sort | Margarita Panagiotopoulou |
| collection | DOAJ |
| description | The objective of this work is to investigate the nanoencapsulation of valuable bioactive compounds with the innovative electrohydrodynamic technology. More specifically, electrospraying, was applied for the encapsulation of three different active agents with lipolytic, anti-aging and antioxidant activity: Deoxycholic acid (DCA), olive leaves’ enzymatically modified extract and a hybrid of Deoxycholic acid-Hydroxytyrosol (DCA-HXT) in zein (ZN) biodegradable polymer. The resulting powders were evaluated regarding the system's: compositional and chemical characteristics, thermal stability and humidity effect, morphology, shape and size, encapsulation efficiency and release kinetics from the wall material. Encapsulation led to stable nanosystems, regarding the moisture and temperature effect, with high glass Transition Temperatures (Tg between 130-139 °C), and a mean particle size of 400-600 nm. Finally, high encapsulation efficiencies (DCA= 84.01%, DCA-HXT = 79.34% and modified extract =80.75%) and long-term release profiles (DCA=192 h, DCA-HXT=228 h and mod. extract=100 h) were measured for all three systems. Based on these results, we conclude that electrospraying process is an effective methodology for the development of bioactive agents’ nanosystems with excellent physicochemical properties and increased bioavailability; a crucial factor for the formation of high added-value products such as cosmetics. |
| first_indexed | 2024-04-12T18:48:44Z |
| format | Article |
| id | doaj.art-00877557c104468e92e0850ca8abd1ca |
| institution | Directory Open Access Journal |
| issn | 1026-9185 |
| language | English |
| last_indexed | 2024-04-12T18:48:44Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | South African Journal of Chemical Engineering |
| spelling | doaj.art-00877557c104468e92e0850ca8abd1ca2022-12-22T03:20:32ZengElsevierSouth African Journal of Chemical Engineering1026-91852022-04-01403247Formation and characterization of zein electrosprayed nanoparticles containing bioactive compoundsMargarita Panagiotopoulou0Sofia Papadaki1Magdalini Krokida2Corresponding author,; Laboratory of Process Analysis and Design, School of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str., Zografou Campus, 15780 Athens, GreeceLaboratory of Process Analysis and Design, School of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str., Zografou Campus, 15780 Athens, GreeceLaboratory of Process Analysis and Design, School of Chemical Engineering, National Technical University of Athens, 9 Iroon Polytechniou Str., Zografou Campus, 15780 Athens, GreeceThe objective of this work is to investigate the nanoencapsulation of valuable bioactive compounds with the innovative electrohydrodynamic technology. More specifically, electrospraying, was applied for the encapsulation of three different active agents with lipolytic, anti-aging and antioxidant activity: Deoxycholic acid (DCA), olive leaves’ enzymatically modified extract and a hybrid of Deoxycholic acid-Hydroxytyrosol (DCA-HXT) in zein (ZN) biodegradable polymer. The resulting powders were evaluated regarding the system's: compositional and chemical characteristics, thermal stability and humidity effect, morphology, shape and size, encapsulation efficiency and release kinetics from the wall material. Encapsulation led to stable nanosystems, regarding the moisture and temperature effect, with high glass Transition Temperatures (Tg between 130-139 °C), and a mean particle size of 400-600 nm. Finally, high encapsulation efficiencies (DCA= 84.01%, DCA-HXT = 79.34% and modified extract =80.75%) and long-term release profiles (DCA=192 h, DCA-HXT=228 h and mod. extract=100 h) were measured for all three systems. Based on these results, we conclude that electrospraying process is an effective methodology for the development of bioactive agents’ nanosystems with excellent physicochemical properties and increased bioavailability; a crucial factor for the formation of high added-value products such as cosmetics.http://www.sciencedirect.com/science/article/pii/S1026918522000051Electrohydrodynamic processElectrosprayingEncapsulation efficiencyNanoparticlesPhysicochemical propertiesRelease Mechanism |
| spellingShingle | Margarita Panagiotopoulou Sofia Papadaki Magdalini Krokida Formation and characterization of zein electrosprayed nanoparticles containing bioactive compounds South African Journal of Chemical Engineering Electrohydrodynamic process Electrospraying Encapsulation efficiency Nanoparticles Physicochemical properties Release Mechanism |
| title | Formation and characterization of zein electrosprayed nanoparticles containing bioactive compounds |
| title_full | Formation and characterization of zein electrosprayed nanoparticles containing bioactive compounds |
| title_fullStr | Formation and characterization of zein electrosprayed nanoparticles containing bioactive compounds |
| title_full_unstemmed | Formation and characterization of zein electrosprayed nanoparticles containing bioactive compounds |
| title_short | Formation and characterization of zein electrosprayed nanoparticles containing bioactive compounds |
| title_sort | formation and characterization of zein electrosprayed nanoparticles containing bioactive compounds |
| topic | Electrohydrodynamic process Electrospraying Encapsulation efficiency Nanoparticles Physicochemical properties Release Mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S1026918522000051 |
| work_keys_str_mv | AT margaritapanagiotopoulou formationandcharacterizationofzeinelectrosprayednanoparticlescontainingbioactivecompounds AT sofiapapadaki formationandcharacterizationofzeinelectrosprayednanoparticlescontainingbioactivecompounds AT magdalinikrokida formationandcharacterizationofzeinelectrosprayednanoparticlescontainingbioactivecompounds |