Serum cystatin C is an early renal dysfunction biomarker in patients with hepatitis C virus
Abstract Background Hepatitis C virus (HCV) may induce extrahepatic manifestations as acute or chronic renal dysfunction. The aim was to evaluate the diagnostic role of some biomarkers as cystatin C, cryoglobulins, rheumatoid factor (RF), and complement C3 for extrahepatic renal affection in newly d...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-11-01
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| Series: | Egyptian Liver Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43066-022-00231-x |
| _version_ | 1811304640141066240 |
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| author | Nagwa Mohamed Assem Amany Ibrahim Mohammed Hamed Mohamed Abdel Barry Ibrahim El Tantawy El Sayed Ibrahim Elmadbouh |
| author_facet | Nagwa Mohamed Assem Amany Ibrahim Mohammed Hamed Mohamed Abdel Barry Ibrahim El Tantawy El Sayed Ibrahim Elmadbouh |
| author_sort | Nagwa Mohamed Assem |
| collection | DOAJ |
| description | Abstract Background Hepatitis C virus (HCV) may induce extrahepatic manifestations as acute or chronic renal dysfunction. The aim was to evaluate the diagnostic role of some biomarkers as cystatin C, cryoglobulins, rheumatoid factor (RF), and complement C3 for extrahepatic renal affection in newly diagnosed patients with HCV infection. Methods Blood and urine were collected from randomized individuals screened for new HCV infection (n=400). The studied populations were divided into 3 groups: control group I: thirty healthy individuals not suffering from either liver or kidney diseases, group IIa: thirty HCV patients who have positive HCV antibody test but showed negative PCR test, and group IIb: thirty HCV patients who showed positive results for both HCV antibody and PCR tests. Results In HCV group IIb, levels of serum total bilirubin, AST and ALT, and urine albumin/creatinine ratio were increased whereas serum albumin and creatinine clearance were decreased versus other groups. However, the levels of blood urea nitrogen and serum creatinine were still within the normal range in all groups. In HCV group IIb, cystatin C, cryoglobulins, and RF levels were increased; meanwhile, serum creatinine/cystatin C ratio and complement 3 levels were decreased compared to the other groups. HCV-infected patients significantly had higher serum cystatin C (>1.24 mg/L, P<0.001) and lower creatinine/cystatin C ratio (<70.1μMol/mg, P=0.002), and cystatin C was significantly correlated with liver and kidney parameters. Conclusion High serum cystatin C and low creatinine/cystatin C ratio may be early indicators of mild renal dysfunction with normal serum levels of creatinine in HCV-infected individuals. |
| first_indexed | 2024-04-13T08:09:48Z |
| format | Article |
| id | doaj.art-00896897893f4a0bab2a1ead70e1f20f |
| institution | Directory Open Access Journal |
| issn | 2090-6226 |
| language | English |
| last_indexed | 2024-04-13T08:09:48Z |
| publishDate | 2022-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Liver Journal |
| spelling | doaj.art-00896897893f4a0bab2a1ead70e1f20f2022-12-22T02:55:00ZengSpringerOpenEgyptian Liver Journal2090-62262022-11-011211810.1186/s43066-022-00231-xSerum cystatin C is an early renal dysfunction biomarker in patients with hepatitis C virusNagwa Mohamed Assem0Amany Ibrahim Mohammed1Hamed Mohamed Abdel Barry2Ibrahim El Tantawy El Sayed3Ibrahim Elmadbouh4Department of Biochemistry, Medical Research Institute, Alexandria UniversityChemistry Department, Faculty of Science, Menoufia UniversityChemistry Department, Faculty of Science, Menoufia UniversityChemistry Department, Faculty of Science, Menoufia UniversityDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia UniversityAbstract Background Hepatitis C virus (HCV) may induce extrahepatic manifestations as acute or chronic renal dysfunction. The aim was to evaluate the diagnostic role of some biomarkers as cystatin C, cryoglobulins, rheumatoid factor (RF), and complement C3 for extrahepatic renal affection in newly diagnosed patients with HCV infection. Methods Blood and urine were collected from randomized individuals screened for new HCV infection (n=400). The studied populations were divided into 3 groups: control group I: thirty healthy individuals not suffering from either liver or kidney diseases, group IIa: thirty HCV patients who have positive HCV antibody test but showed negative PCR test, and group IIb: thirty HCV patients who showed positive results for both HCV antibody and PCR tests. Results In HCV group IIb, levels of serum total bilirubin, AST and ALT, and urine albumin/creatinine ratio were increased whereas serum albumin and creatinine clearance were decreased versus other groups. However, the levels of blood urea nitrogen and serum creatinine were still within the normal range in all groups. In HCV group IIb, cystatin C, cryoglobulins, and RF levels were increased; meanwhile, serum creatinine/cystatin C ratio and complement 3 levels were decreased compared to the other groups. HCV-infected patients significantly had higher serum cystatin C (>1.24 mg/L, P<0.001) and lower creatinine/cystatin C ratio (<70.1μMol/mg, P=0.002), and cystatin C was significantly correlated with liver and kidney parameters. Conclusion High serum cystatin C and low creatinine/cystatin C ratio may be early indicators of mild renal dysfunction with normal serum levels of creatinine in HCV-infected individuals.https://doi.org/10.1186/s43066-022-00231-xHCVAKICryoglobulinsCystatin CComplement C3RF |
| spellingShingle | Nagwa Mohamed Assem Amany Ibrahim Mohammed Hamed Mohamed Abdel Barry Ibrahim El Tantawy El Sayed Ibrahim Elmadbouh Serum cystatin C is an early renal dysfunction biomarker in patients with hepatitis C virus Egyptian Liver Journal HCV AKI Cryoglobulins Cystatin C Complement C3 RF |
| title | Serum cystatin C is an early renal dysfunction biomarker in patients with hepatitis C virus |
| title_full | Serum cystatin C is an early renal dysfunction biomarker in patients with hepatitis C virus |
| title_fullStr | Serum cystatin C is an early renal dysfunction biomarker in patients with hepatitis C virus |
| title_full_unstemmed | Serum cystatin C is an early renal dysfunction biomarker in patients with hepatitis C virus |
| title_short | Serum cystatin C is an early renal dysfunction biomarker in patients with hepatitis C virus |
| title_sort | serum cystatin c is an early renal dysfunction biomarker in patients with hepatitis c virus |
| topic | HCV AKI Cryoglobulins Cystatin C Complement C3 RF |
| url | https://doi.org/10.1186/s43066-022-00231-x |
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