Effect of hydroalcoholic extract of Aloe vera and Teucrium on serum glucose and lipid profile in streptozotocin diabetic male rats
Background and Aim: Aloe vera (Aloe barbadensis) and Teucrium (Teucrium polium) are used in traditional medicine as anti-diabetic herbs. The present study examined the effects of TP and aloe vera extracts on some metabolites like glucose, total cholesterol, LDL, HDL, VLDL and triglycerides in strept...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | fas |
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Birjand University of Medical Sciences and Health Services
2013-08-01
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| Series: | مجله دانشگاه علوم پزشکی بیرجند |
| Subjects: | |
| Online Access: | http://journal.bums.ac.ir/browse.php?a_code=A-10-870-3&slc_lang=en&sid=1 |
| _version_ | 1817977980251537408 |
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| author | Alireza Ayoubi Arash Omidi Reza Valizade Amir Mousaei |
| author_facet | Alireza Ayoubi Arash Omidi Reza Valizade Amir Mousaei |
| author_sort | Alireza Ayoubi |
| collection | DOAJ |
| description | Background and Aim: Aloe vera (Aloe barbadensis) and Teucrium (Teucrium polium) are used in traditional medicine as anti-diabetic herbs. The present study examined the effects of TP and aloe vera extracts on some metabolites like glucose, total cholesterol, LDL, HDL, VLDL and triglycerides in streptozotocin-induced diabetic Wistar rats.
Materials and Methods: In this experimental research, forty rats were randomly divided into five equal groups. Trials in the study included the control group, diabetics (50 mg/kg STZ), diabetics+extract of Aloe vera (300mg/kg), diabetics+Teucrium (300mg/kg), and diabetics+glibenclamide (5mg/kg). All solutions were given orally for 14 days. Blood samples of the rats were derived from their hearts on the 15th day of the experiment and their serum was isolated.
Results: Blood glucose in diabetic rats significantly reduced by aloe vera and Teucrium extracts (P≤0.05). It was found that concentration of total cholesterol, HDL, VLDL and triglycerides in rats receiving Aloe vera and Teucrium extracts and glibenclamide was significantly lower than diabetic rats (P≤0.05). Aloe vera and Teucrium were more effective than glibenclamide in reducing blood cholesterol levels. Compared with Aloe vera and glibenclamidettreatment with Teucrium had less effect on serum triglycerides. Serum insulin levels in diabetic animals receiving the herbs extracts significantly increased in comparison with diabetic rats.
Conclusion: The use of Aloe vera and Teucrium extracts improve insulin secretion and reduce blood glucose and LDL |
| first_indexed | 2024-04-13T22:23:27Z |
| format | Article |
| id | doaj.art-00899e1574734ed995d364cee458aa1f |
| institution | Directory Open Access Journal |
| issn | 1607-2197 2423-6152 |
| language | fas |
| last_indexed | 2024-04-13T22:23:27Z |
| publishDate | 2013-08-01 |
| publisher | Birjand University of Medical Sciences and Health Services |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی بیرجند |
| spelling | doaj.art-00899e1574734ed995d364cee458aa1f2022-12-22T02:27:07ZfasBirjand University of Medical Sciences and Health Servicesمجله دانشگاه علوم پزشکی بیرجند1607-21972423-61522013-08-01202144152Effect of hydroalcoholic extract of Aloe vera and Teucrium on serum glucose and lipid profile in streptozotocin diabetic male ratsAlireza Ayoubi0Arash Omidi1Reza Valizade2Amir Mousaei3 in Animal Physiology, Department of Animal Science, Ferdowsi University of Mashhad Department of Animal Health Management, Faculty of Veterinary Medicine, Shiraz Department of Animal Science, Ferdowsi University of Mashhad Department of Animal Science, Ferdowsi University of Mashhad Background and Aim: Aloe vera (Aloe barbadensis) and Teucrium (Teucrium polium) are used in traditional medicine as anti-diabetic herbs. The present study examined the effects of TP and aloe vera extracts on some metabolites like glucose, total cholesterol, LDL, HDL, VLDL and triglycerides in streptozotocin-induced diabetic Wistar rats. Materials and Methods: In this experimental research, forty rats were randomly divided into five equal groups. Trials in the study included the control group, diabetics (50 mg/kg STZ), diabetics+extract of Aloe vera (300mg/kg), diabetics+Teucrium (300mg/kg), and diabetics+glibenclamide (5mg/kg). All solutions were given orally for 14 days. Blood samples of the rats were derived from their hearts on the 15th day of the experiment and their serum was isolated. Results: Blood glucose in diabetic rats significantly reduced by aloe vera and Teucrium extracts (P≤0.05). It was found that concentration of total cholesterol, HDL, VLDL and triglycerides in rats receiving Aloe vera and Teucrium extracts and glibenclamide was significantly lower than diabetic rats (P≤0.05). Aloe vera and Teucrium were more effective than glibenclamide in reducing blood cholesterol levels. Compared with Aloe vera and glibenclamidettreatment with Teucrium had less effect on serum triglycerides. Serum insulin levels in diabetic animals receiving the herbs extracts significantly increased in comparison with diabetic rats. Conclusion: The use of Aloe vera and Teucrium extracts improve insulin secretion and reduce blood glucose and LDLhttp://journal.bums.ac.ir/browse.php?a_code=A-10-870-3&slc_lang=en&sid=1Diabetes Aloe vera Teucrium Lipid profile Glucose Insulin |
| spellingShingle | Alireza Ayoubi Arash Omidi Reza Valizade Amir Mousaei Effect of hydroalcoholic extract of Aloe vera and Teucrium on serum glucose and lipid profile in streptozotocin diabetic male rats مجله دانشگاه علوم پزشکی بیرجند Diabetes Aloe vera Teucrium Lipid profile Glucose Insulin |
| title | Effect of hydroalcoholic extract of Aloe vera and Teucrium on serum glucose and lipid profile in streptozotocin diabetic male rats |
| title_full | Effect of hydroalcoholic extract of Aloe vera and Teucrium on serum glucose and lipid profile in streptozotocin diabetic male rats |
| title_fullStr | Effect of hydroalcoholic extract of Aloe vera and Teucrium on serum glucose and lipid profile in streptozotocin diabetic male rats |
| title_full_unstemmed | Effect of hydroalcoholic extract of Aloe vera and Teucrium on serum glucose and lipid profile in streptozotocin diabetic male rats |
| title_short | Effect of hydroalcoholic extract of Aloe vera and Teucrium on serum glucose and lipid profile in streptozotocin diabetic male rats |
| title_sort | effect of hydroalcoholic extract of aloe vera and teucrium on serum glucose and lipid profile in streptozotocin diabetic male rats |
| topic | Diabetes Aloe vera Teucrium Lipid profile Glucose Insulin |
| url | http://journal.bums.ac.ir/browse.php?a_code=A-10-870-3&slc_lang=en&sid=1 |
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