Paraneoplastic endocrinopathy in Castleman disease and POEMS syndrome
Polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes (POEMS) syndrome is a rare paraneoplastic syndrome associated with Castleman disease, monoclonal gammopathy of undetermined significance, symptomatic hemoblastosis or systemic autoimmune diseases. Slow development, nonspecifity of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2020-10-01
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| Series: | Онкогематология |
| Subjects: | |
| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/433 |
| _version_ | 1797855515452112896 |
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| author | V. I. Odin A. S. Polyakov A. V. Kovalev S. V. ondarchuk V. V. Tyrenko A. M. Mykhailov T. Yu. Bogovskaya |
| author_facet | V. I. Odin A. S. Polyakov A. V. Kovalev S. V. ondarchuk V. V. Tyrenko A. M. Mykhailov T. Yu. Bogovskaya |
| author_sort | V. I. Odin |
| collection | DOAJ |
| description | Polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes (POEMS) syndrome is a rare paraneoplastic syndrome associated with Castleman disease, monoclonal gammopathy of undetermined significance, symptomatic hemoblastosis or systemic autoimmune diseases. Slow development, nonspecifity of most clinical manifestations and lack of awareness of physicians are the main reasons for the late access to medical care and a long, sometimes many years, diagnostic search. Even after diagnosis, the use of modern methods of immunosuppressive, immunomodulating or antitumor therapy is significantly limited by the difficulties of taxonomic classification of the diagnosis, the lack of unified therapeutic approaches, and related unresolved issues of profiling and drug provision of patients. The article provides an overview of the basic information about the pathogenesis and clinical manifestations of POEMS syndrome. Using the example of a patient with Castleman’s disease, the difficulties of primary diagnosis of POEMS syndrome and the problems of interdisciplinary interaction of doctors of various specialties are demonstrated. The significance of endocrine disorders in the diagnosis and treatment planning is analyzed. |
| first_indexed | 2024-04-09T20:23:51Z |
| format | Article |
| id | doaj.art-008a7eaca7064c73b3c5eacea24f001e |
| institution | Directory Open Access Journal |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| last_indexed | 2024-04-09T20:23:51Z |
| publishDate | 2020-10-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-008a7eaca7064c73b3c5eacea24f001e2023-03-30T20:15:13ZrusABV-pressОнкогематология1818-83462413-40232020-10-01153677910.17650/1818-8346-2020-15-3-67-79360Paraneoplastic endocrinopathy in Castleman disease and POEMS syndromeV. I. Odin0A. S. Polyakov1A. V. Kovalev2S. V. ondarchuk3V. V. Tyrenko4A. M. Mykhailov5T. Yu. Bogovskaya6Department and Clinic of Faculty Therapy named after S. P. Botkin, C. M. Kirov Military Medical Academy, Russian Defense MinistryDepartment and Clinic of Faculty Therapy named after S. P. Botkin, C. M. Kirov Military Medical Academy, Russian Defense MinistryDepartment and Clinic of Faculty Therapy named after S. P. Botkin, C. M. Kirov Military Medical Academy, Russian Defense MinistryDepartment and Clinic of Faculty Therapy named after S. P. Botkin, C. M. Kirov Military Medical Academy, Russian Defense MinistryDepartment and Clinic of Faculty Therapy named after S. P. Botkin, C. M. Kirov Military Medical Academy, Russian Defense MinistryDepartment of Hospital Therapy and Cardiology named after M. S. Kushakovsky, I. I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaLabTestPolyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes (POEMS) syndrome is a rare paraneoplastic syndrome associated with Castleman disease, monoclonal gammopathy of undetermined significance, symptomatic hemoblastosis or systemic autoimmune diseases. Slow development, nonspecifity of most clinical manifestations and lack of awareness of physicians are the main reasons for the late access to medical care and a long, sometimes many years, diagnostic search. Even after diagnosis, the use of modern methods of immunosuppressive, immunomodulating or antitumor therapy is significantly limited by the difficulties of taxonomic classification of the diagnosis, the lack of unified therapeutic approaches, and related unresolved issues of profiling and drug provision of patients. The article provides an overview of the basic information about the pathogenesis and clinical manifestations of POEMS syndrome. Using the example of a patient with Castleman’s disease, the difficulties of primary diagnosis of POEMS syndrome and the problems of interdisciplinary interaction of doctors of various specialties are demonstrated. The significance of endocrine disorders in the diagnosis and treatment planning is analyzed.https://oncohematology.abvpress.ru/ongm/article/view/433poems-syndromecastleman diseaseparaneoplastic endocrinopathyendocrinopathytestosteronehypogonadismhypothyroidismdermopathyneuropathyvegf |
| spellingShingle | V. I. Odin A. S. Polyakov A. V. Kovalev S. V. ondarchuk V. V. Tyrenko A. M. Mykhailov T. Yu. Bogovskaya Paraneoplastic endocrinopathy in Castleman disease and POEMS syndrome Онкогематология poems-syndrome castleman disease paraneoplastic endocrinopathy endocrinopathy testosterone hypogonadism hypothyroidism dermopathy neuropathy vegf |
| title | Paraneoplastic endocrinopathy in Castleman disease and POEMS syndrome |
| title_full | Paraneoplastic endocrinopathy in Castleman disease and POEMS syndrome |
| title_fullStr | Paraneoplastic endocrinopathy in Castleman disease and POEMS syndrome |
| title_full_unstemmed | Paraneoplastic endocrinopathy in Castleman disease and POEMS syndrome |
| title_short | Paraneoplastic endocrinopathy in Castleman disease and POEMS syndrome |
| title_sort | paraneoplastic endocrinopathy in castleman disease and poems syndrome |
| topic | poems-syndrome castleman disease paraneoplastic endocrinopathy endocrinopathy testosterone hypogonadism hypothyroidism dermopathy neuropathy vegf |
| url | https://oncohematology.abvpress.ru/ongm/article/view/433 |
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