In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China
Contezolid is a novel oxazolidinone, which exhibits potent activity against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and penicillin-resistant Streptococcus pneumoniae (PRSP). In this study, the in vitro activity of...
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| Format: | Article |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.729900/full |
| _version_ | 1818577176161681408 |
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| author | Siheng Wang Chang Cai Yingbo Shen Chengtao Sun Qingxin Shi Ningjun Wu Shufang Zheng Jiao Qian Rong Zhang Hongwei Zhou |
| author_facet | Siheng Wang Chang Cai Yingbo Shen Chengtao Sun Qingxin Shi Ningjun Wu Shufang Zheng Jiao Qian Rong Zhang Hongwei Zhou |
| author_sort | Siheng Wang |
| collection | DOAJ |
| description | Contezolid is a novel oxazolidinone, which exhibits potent activity against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and penicillin-resistant Streptococcus pneumoniae (PRSP). In this study, the in vitro activity of contezolid was compared with linezolid (LZD), tigecycline (TGC), teicoplanin (TEC), vancomycin (VA), daptomycin (DAP), and florfenicol (FFC) against MRSA and VRE strains isolated from China. Contezolid revealed considerable activity against MRSA and VRE isolates with MIC90 values of 0.5 and 1.0 μg/mL, respectively. For VRE strains with different resistance genotypes, including vanA- and vanM-type strains, contezolid did not exhibit significantly differential antibacterial activity. Furthermore, the antimicrobial activity of contezolid is similar to or slightly better than that of linezolid against MRSA and VRE strains. Subsequently, the activity of contezolid was tested against strains carrying linezolid resistance genes, including Staphylococcus capitis carrying cfr gene and Enterococcus faecalis carrying optrA gene. The results showed that contezolid exhibited similar antimicrobial efficacy to linezolid against strains with linezolid resistance genes. In general, contezolid may have potential benefits to treat the infections caused by MRSA and VRE pathogens. |
| first_indexed | 2024-12-16T06:25:45Z |
| format | Article |
| id | doaj.art-008bd330979f49a08d81568384f2a3c2 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-16T06:25:45Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-008bd330979f49a08d81568384f2a3c22022-12-21T22:41:00ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-08-011210.3389/fmicb.2021.729900729900In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From ChinaSiheng Wang0Chang Cai1Yingbo Shen2Chengtao Sun3Qingxin Shi4Ningjun Wu5Shufang Zheng6Jiao Qian7Rong Zhang8Hongwei Zhou9Clinical Microbiology Laboratory, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, ChinaChina Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology, Zhejiang Agricultural and Forestry University, Hangzhou, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaClinical Laboratory Department, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, ChinaClinical Laboratory, Lishui People’s Hospital, Lishui, ChinaDepartment of Laboratory Medicine, Jinhua People’s Hospital, Jinhua, ChinaClinical Laboratory Department, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, ChinaClinical Microbiology Laboratory, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, ChinaClinical Microbiology Laboratory, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, ChinaContezolid is a novel oxazolidinone, which exhibits potent activity against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and penicillin-resistant Streptococcus pneumoniae (PRSP). In this study, the in vitro activity of contezolid was compared with linezolid (LZD), tigecycline (TGC), teicoplanin (TEC), vancomycin (VA), daptomycin (DAP), and florfenicol (FFC) against MRSA and VRE strains isolated from China. Contezolid revealed considerable activity against MRSA and VRE isolates with MIC90 values of 0.5 and 1.0 μg/mL, respectively. For VRE strains with different resistance genotypes, including vanA- and vanM-type strains, contezolid did not exhibit significantly differential antibacterial activity. Furthermore, the antimicrobial activity of contezolid is similar to or slightly better than that of linezolid against MRSA and VRE strains. Subsequently, the activity of contezolid was tested against strains carrying linezolid resistance genes, including Staphylococcus capitis carrying cfr gene and Enterococcus faecalis carrying optrA gene. The results showed that contezolid exhibited similar antimicrobial efficacy to linezolid against strains with linezolid resistance genes. In general, contezolid may have potential benefits to treat the infections caused by MRSA and VRE pathogens.https://www.frontiersin.org/articles/10.3389/fmicb.2021.729900/fullcontezolidmethicillin-resistant Staphylococcus aureusvancomycin-resistant Enterococcuslinezolidantibioticsantimicrobial activity |
| spellingShingle | Siheng Wang Chang Cai Yingbo Shen Chengtao Sun Qingxin Shi Ningjun Wu Shufang Zheng Jiao Qian Rong Zhang Hongwei Zhou In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China Frontiers in Microbiology contezolid methicillin-resistant Staphylococcus aureus vancomycin-resistant Enterococcus linezolid antibiotics antimicrobial activity |
| title | In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China |
| title_full | In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China |
| title_fullStr | In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China |
| title_full_unstemmed | In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China |
| title_short | In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China |
| title_sort | in vitro activity of contezolid against methicillin resistant staphylococcus aureus vancomycin resistant enterococcus and strains with linezolid resistance genes from china |
| topic | contezolid methicillin-resistant Staphylococcus aureus vancomycin-resistant Enterococcus linezolid antibiotics antimicrobial activity |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.729900/full |
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