A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate
We report a 57-year old man with polycythemia vera, who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate. The patient was treated with this combination for 56 months, and during this period the patient has been in complete hematological remissio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | Leukemia Research Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048916300127 |
| _version_ | 1818481792272826368 |
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| author | Anders Lindholm Sørensen Klaus Kallenbach Hans Carl Hasselbalch |
| author_facet | Anders Lindholm Sørensen Klaus Kallenbach Hans Carl Hasselbalch |
| author_sort | Anders Lindholm Sørensen |
| collection | DOAJ |
| description | We report a 57-year old man with polycythemia vera, who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate. The patient was treated with this combination for 56 months, and during this period the patient has been in complete hematological remission. The JAK2-V617F allele burden has dropped from 64% to sustained values below 20%, and follow-up bone marrow biopsies have revealed no change in PV features, without any regular cytoreductive treatment. |
| first_indexed | 2024-12-10T11:39:46Z |
| format | Article |
| id | doaj.art-008c01d5289e459fa76c95295ec7fc2c |
| institution | Directory Open Access Journal |
| issn | 2213-0489 |
| language | English |
| last_indexed | 2024-12-10T11:39:46Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj.art-008c01d5289e459fa76c95295ec7fc2c2022-12-22T01:50:16ZengElsevierLeukemia Research Reports2213-04892016-01-016C202310.1016/j.lrr.2016.06.004A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronateAnders Lindholm Sørensen0Klaus Kallenbach1Hans Carl Hasselbalch2Department of Hematology, Zealand University Hospital, DenmarkDepartment of Pathology, Zealand University Hospital, DenmarkDepartment of Hematology, Zealand University Hospital, DenmarkWe report a 57-year old man with polycythemia vera, who had a remarkable hematological and molecular response during treatment with simvastatin and alendronate. The patient was treated with this combination for 56 months, and during this period the patient has been in complete hematological remission. The JAK2-V617F allele burden has dropped from 64% to sustained values below 20%, and follow-up bone marrow biopsies have revealed no change in PV features, without any regular cytoreductive treatment.http://www.sciencedirect.com/science/article/pii/S2213048916300127Myeloproliferative neoplasmsPolycythemia veraJAK2-V617F mutationSimvastatinAlendronate |
| spellingShingle | Anders Lindholm Sørensen Klaus Kallenbach Hans Carl Hasselbalch A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate Leukemia Research Reports Myeloproliferative neoplasms Polycythemia vera JAK2-V617F mutation Simvastatin Alendronate |
| title | A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate |
| title_full | A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate |
| title_fullStr | A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate |
| title_full_unstemmed | A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate |
| title_short | A remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate |
| title_sort | remarkable hematological and molecular response pattern in a patient with polycythemia vera during combination therapy with simvastatin and alendronate |
| topic | Myeloproliferative neoplasms Polycythemia vera JAK2-V617F mutation Simvastatin Alendronate |
| url | http://www.sciencedirect.com/science/article/pii/S2213048916300127 |
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