Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands
Background: We investigated whether low socioeconomic status (SES), which is associated with reduced health and life expectancy, might play a role in increased risk for infectious diseases. Therefore, we explored the association between SES and immunoglobulin G (IgG) levels against various pathogens...
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| Format: | Article |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpubh.2018.00209/full |
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| author | Joske Hoes Anna G. C. Boef Mirjam J. Knol Hester E. de Melker Liesbeth Mollema Fiona R. M. van der Klis Nynke Y. Rots Debbie van Baarle Debbie van Baarle |
| author_facet | Joske Hoes Anna G. C. Boef Mirjam J. Knol Hester E. de Melker Liesbeth Mollema Fiona R. M. van der Klis Nynke Y. Rots Debbie van Baarle Debbie van Baarle |
| author_sort | Joske Hoes |
| collection | DOAJ |
| description | Background: We investigated whether low socioeconomic status (SES), which is associated with reduced health and life expectancy, might play a role in increased risk for infectious diseases. Therefore, we explored the association between SES and immunoglobulin G (IgG) levels against various pathogens.Methods: We analyzed the association between SES [educational level and net household income (NHI)] and serum IgG concentration against measles, mumps, rubella, varicella, Haemophilus influenzae type B (HiB), pneumococcus, meningococcus serogroup C (MenC), and cytomegalovirus (CMV) collected within a national cross-sectional serosurvey (2006/2007) using linear regression analyses among non-vaccinated individuals.Results: Higher educational level was associated with higher IgG concentrations against measles (GMC ratio 1.34, 95% CI 1.18–1.53) and rubella (1.13, 1.02–1.25) compared to low education level. In contrast, higher education level was associated with lower IgG concentrations against pneumococcus (0.78, 0.70–0.88), MenC (0.54, 0.44–0.68), and CMV (0.23, 0.18–0.31) compared to low education level. This pattern was also evident when NHI was used as SES indicator.Conclusion: Our study suggests that socioeconomic status is associated with antibody levels in a pathogen-dependent manner. The results suggest that differences in serological response upon infection or differences in exposure might be involved in the variation in IgG levels between SES groups. |
| first_indexed | 2024-12-14T13:48:37Z |
| format | Article |
| id | doaj.art-008c368be6b64d86b8f637044117987e |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-14T13:48:37Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-008c368be6b64d86b8f637044117987e2022-12-21T22:59:12ZengFrontiers Media S.A.Frontiers in Public Health2296-25652018-07-01610.3389/fpubh.2018.00209341301Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the NetherlandsJoske Hoes0Anna G. C. Boef1Mirjam J. Knol2Hester E. de Melker3Liesbeth Mollema4Fiona R. M. van der Klis5Nynke Y. Rots6Debbie van Baarle7Debbie van Baarle8Centre for Epidemiology and Surveillance of Infectious Diseases, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, NetherlandsCentre for Epidemiology and Surveillance of Infectious Diseases, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, NetherlandsCentre for Epidemiology and Surveillance of Infectious Diseases, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, NetherlandsCentre for Epidemiology and Surveillance of Infectious Diseases, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, NetherlandsCentre for Epidemiology and Surveillance of Infectious Diseases, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, NetherlandsCentre for Immunology of Infectious Diseases and Vaccines, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, NetherlandsCentre for Immunology of Infectious Diseases and Vaccines, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, NetherlandsCentre for Immunology of Infectious Diseases and Vaccines, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, NetherlandsLaboratory for Translational Immunology, Department Immunology, University Medical Centre Utrecht, Utrecht, NetherlandsBackground: We investigated whether low socioeconomic status (SES), which is associated with reduced health and life expectancy, might play a role in increased risk for infectious diseases. Therefore, we explored the association between SES and immunoglobulin G (IgG) levels against various pathogens.Methods: We analyzed the association between SES [educational level and net household income (NHI)] and serum IgG concentration against measles, mumps, rubella, varicella, Haemophilus influenzae type B (HiB), pneumococcus, meningococcus serogroup C (MenC), and cytomegalovirus (CMV) collected within a national cross-sectional serosurvey (2006/2007) using linear regression analyses among non-vaccinated individuals.Results: Higher educational level was associated with higher IgG concentrations against measles (GMC ratio 1.34, 95% CI 1.18–1.53) and rubella (1.13, 1.02–1.25) compared to low education level. In contrast, higher education level was associated with lower IgG concentrations against pneumococcus (0.78, 0.70–0.88), MenC (0.54, 0.44–0.68), and CMV (0.23, 0.18–0.31) compared to low education level. This pattern was also evident when NHI was used as SES indicator.Conclusion: Our study suggests that socioeconomic status is associated with antibody levels in a pathogen-dependent manner. The results suggest that differences in serological response upon infection or differences in exposure might be involved in the variation in IgG levels between SES groups.https://www.frontiersin.org/article/10.3389/fpubh.2018.00209/fullvaccine preventable diseasesimmunoglobulin Gsocioeconomic statusantibody levelcytomegalovirus |
| spellingShingle | Joske Hoes Anna G. C. Boef Mirjam J. Knol Hester E. de Melker Liesbeth Mollema Fiona R. M. van der Klis Nynke Y. Rots Debbie van Baarle Debbie van Baarle Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands Frontiers in Public Health vaccine preventable diseases immunoglobulin G socioeconomic status antibody level cytomegalovirus |
| title | Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands |
| title_full | Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands |
| title_fullStr | Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands |
| title_full_unstemmed | Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands |
| title_short | Socioeconomic Status Is Associated With Antibody Levels Against Vaccine Preventable Diseases in the Netherlands |
| title_sort | socioeconomic status is associated with antibody levels against vaccine preventable diseases in the netherlands |
| topic | vaccine preventable diseases immunoglobulin G socioeconomic status antibody level cytomegalovirus |
| url | https://www.frontiersin.org/article/10.3389/fpubh.2018.00209/full |
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