Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis
Epidemiological and experimental evidence has emerged that a dysregulated inflammation is associated with most of the tumors, and many studies have begun to unravel the molecular pathways linking inflammation and cancer. As a typical example linking these associations, Helicobacter pylori (H. pylori...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/3/3/3018/ |
| _version_ | 1797765922598944768 |
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| author | Ki Baik Hahm Hua Hong Eun-Hee Kim Kyung-Sook Hong |
| author_facet | Ki Baik Hahm Hua Hong Eun-Hee Kim Kyung-Sook Hong |
| author_sort | Ki Baik Hahm |
| collection | DOAJ |
| description | Epidemiological and experimental evidence has emerged that a dysregulated inflammation is associated with most of the tumors, and many studies have begun to unravel the molecular pathways linking inflammation and cancer. As a typical example linking these associations, Helicobacter pylori (H. pylori) infection-associated atrophic gastritis has been recognized as precursor lesion of gastric cancer. The identification of transcription factors such as NF-κB and STAT3, and their gene products such as IL-8, COX-2, iNOS, cytokines, chemokines and their receptors, etc have laid the molecular foundation for our understanding of the decisive role of inflammation in carcinogenesis. In addition to the role as the initiator of cancer, inflammation contributes to survival and proliferation of malignant cells, tumor angiogenesis, and even metastasis. In this review, the fundamental mechanisms of H. pylori-induced carcinogenesis as well as the possibility of cancer prevention through suppressing H. pylori-induced inflammation are introduced. We infer that targeting inflammatory pathways have a potential role to detour the unpleasant journey to H. pylori-associated gastric carcinogenesis. |
| first_indexed | 2024-03-12T20:17:06Z |
| format | Article |
| id | doaj.art-008c974ab6b440d59435f2001dd36a5a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T20:17:06Z |
| publishDate | 2011-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-008c974ab6b440d59435f2001dd36a5a2023-08-02T01:11:46ZengMDPI AGCancers2072-66942011-07-01333018302810.3390/cancers3033018Detouring the Undesired Route of Helicobacter pylori-Induced Gastric CarcinogenesisKi Baik HahmHua HongEun-Hee KimKyung-Sook HongEpidemiological and experimental evidence has emerged that a dysregulated inflammation is associated with most of the tumors, and many studies have begun to unravel the molecular pathways linking inflammation and cancer. As a typical example linking these associations, Helicobacter pylori (H. pylori) infection-associated atrophic gastritis has been recognized as precursor lesion of gastric cancer. The identification of transcription factors such as NF-κB and STAT3, and their gene products such as IL-8, COX-2, iNOS, cytokines, chemokines and their receptors, etc have laid the molecular foundation for our understanding of the decisive role of inflammation in carcinogenesis. In addition to the role as the initiator of cancer, inflammation contributes to survival and proliferation of malignant cells, tumor angiogenesis, and even metastasis. In this review, the fundamental mechanisms of H. pylori-induced carcinogenesis as well as the possibility of cancer prevention through suppressing H. pylori-induced inflammation are introduced. We infer that targeting inflammatory pathways have a potential role to detour the unpleasant journey to H. pylori-associated gastric carcinogenesis.http://www.mdpi.com/2072-6694/3/3/3018/gastric cancerinflammationHelicobacter pyloricancer prevention |
| spellingShingle | Ki Baik Hahm Hua Hong Eun-Hee Kim Kyung-Sook Hong Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis Cancers gastric cancer inflammation Helicobacter pylori cancer prevention |
| title | Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis |
| title_full | Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis |
| title_fullStr | Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis |
| title_full_unstemmed | Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis |
| title_short | Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis |
| title_sort | detouring the undesired route of helicobacter pylori induced gastric carcinogenesis |
| topic | gastric cancer inflammation Helicobacter pylori cancer prevention |
| url | http://www.mdpi.com/2072-6694/3/3/3018/ |
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