Study on the correlation between mineral bone metabolism and CRP in patients with SHPT during perioperative period
Abstract Objective This study mainly observes changes in perioperative mineral bone metabolism‐related indicators and inflammatory factors in patients with secondary hyperparathyroidism (SHPT), and analyzed the correlation between mineral bone metabolism‐related indicators and inflammatory factors....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Immunity, Inflammation and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/iid3.828 |
| _version_ | 1797830887598981120 |
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| author | Lei Yan Qiuyue Xiong Qin Xu Pengru Ren Tiantian Li Huixia Cao Fengmin Shao |
| author_facet | Lei Yan Qiuyue Xiong Qin Xu Pengru Ren Tiantian Li Huixia Cao Fengmin Shao |
| author_sort | Lei Yan |
| collection | DOAJ |
| description | Abstract Objective This study mainly observes changes in perioperative mineral bone metabolism‐related indicators and inflammatory factors in patients with secondary hyperparathyroidism (SHPT), and analyzed the correlation between mineral bone metabolism‐related indicators and inflammatory factors. Methods Clinical data were collected. The study detects mineral bone metabolism‐related indicators and inflammatory factor of perioperative patients with SHPT before and 4 days after operation. The production of high‐sensitivity c‐reactive protein (hs‐CRP) in human hepatocytes cells (LO2 cells) stimulated by different concentrations of parathyroid hormone‐associated protein was detected by enzyme‐linked immunosorbent assay, reverse‐transcription polymerase chain reaction (RT‐PCR), and western blot. Results The levels of mineral bone metabolism‐related indicators and hs‐CRP in SHPT group were significantly higher than those of control group. After operation, serum calcium, serum phosphorus, iPTH, FGF‐23 decreased, and the level of osteoblast active biomarkers increased, while the level of osteoclast active biomarkers decreased. The levels of hs‐CRP decreased significantly after operation. With the increase of PTHrP concentration, hs‐CRP level in supernatant of LO2 cells decreased first and then increased. RT‐PCR and western blot shows the same trend. Conclusion Parathyroidectomy can significantly improve bone resorption and inflammation in SHPT patients. We speculate that there may be an optimal range of PTH concentrations to minimize inflammation in the body. |
| first_indexed | 2024-04-09T13:43:35Z |
| format | Article |
| id | doaj.art-008d761398634f67820c9bb3b81274b7 |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-04-09T13:43:35Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-008d761398634f67820c9bb3b81274b72023-05-09T06:57:15ZengWileyImmunity, Inflammation and Disease2050-45272023-04-01114n/an/a10.1002/iid3.828Study on the correlation between mineral bone metabolism and CRP in patients with SHPT during perioperative periodLei Yan0Qiuyue Xiong1Qin Xu2Pengru Ren3Tiantian Li4Huixia Cao5Fengmin Shao6Department of Nephrology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan Provincial Key Laboratory of Kidney Disease and Immunology Henan Provincial Clinical Research Center for Kidney Disease Zhengzhou ChinaDepartment of Nephrology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan Provincial Key Laboratory of Kidney Disease and Immunology Henan Provincial Clinical Research Center for Kidney Disease Zhengzhou ChinaDepartment of Nephrology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan Provincial Key Laboratory of Kidney Disease and Immunology Henan Provincial Clinical Research Center for Kidney Disease Zhengzhou ChinaDepartment of Nephrology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan Provincial Key Laboratory of Kidney Disease and Immunology Henan Provincial Clinical Research Center for Kidney Disease Zhengzhou ChinaDepartment of Nephrology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan Provincial Key Laboratory of Kidney Disease and Immunology Henan Provincial Clinical Research Center for Kidney Disease Zhengzhou ChinaDepartment of Nephrology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan Provincial Key Laboratory of Kidney Disease and Immunology Henan Provincial Clinical Research Center for Kidney Disease Zhengzhou ChinaDepartment of Nephrology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Henan Provincial Key Laboratory of Kidney Disease and Immunology Henan Provincial Clinical Research Center for Kidney Disease Zhengzhou ChinaAbstract Objective This study mainly observes changes in perioperative mineral bone metabolism‐related indicators and inflammatory factors in patients with secondary hyperparathyroidism (SHPT), and analyzed the correlation between mineral bone metabolism‐related indicators and inflammatory factors. Methods Clinical data were collected. The study detects mineral bone metabolism‐related indicators and inflammatory factor of perioperative patients with SHPT before and 4 days after operation. The production of high‐sensitivity c‐reactive protein (hs‐CRP) in human hepatocytes cells (LO2 cells) stimulated by different concentrations of parathyroid hormone‐associated protein was detected by enzyme‐linked immunosorbent assay, reverse‐transcription polymerase chain reaction (RT‐PCR), and western blot. Results The levels of mineral bone metabolism‐related indicators and hs‐CRP in SHPT group were significantly higher than those of control group. After operation, serum calcium, serum phosphorus, iPTH, FGF‐23 decreased, and the level of osteoblast active biomarkers increased, while the level of osteoclast active biomarkers decreased. The levels of hs‐CRP decreased significantly after operation. With the increase of PTHrP concentration, hs‐CRP level in supernatant of LO2 cells decreased first and then increased. RT‐PCR and western blot shows the same trend. Conclusion Parathyroidectomy can significantly improve bone resorption and inflammation in SHPT patients. We speculate that there may be an optimal range of PTH concentrations to minimize inflammation in the body.https://doi.org/10.1002/iid3.828chronic kidney diseaseinflammationmineral bone metabolism disordersparathyroidectomysecondary hyperparathyroidism |
| spellingShingle | Lei Yan Qiuyue Xiong Qin Xu Pengru Ren Tiantian Li Huixia Cao Fengmin Shao Study on the correlation between mineral bone metabolism and CRP in patients with SHPT during perioperative period Immunity, Inflammation and Disease chronic kidney disease inflammation mineral bone metabolism disorders parathyroidectomy secondary hyperparathyroidism |
| title | Study on the correlation between mineral bone metabolism and CRP in patients with SHPT during perioperative period |
| title_full | Study on the correlation between mineral bone metabolism and CRP in patients with SHPT during perioperative period |
| title_fullStr | Study on the correlation between mineral bone metabolism and CRP in patients with SHPT during perioperative period |
| title_full_unstemmed | Study on the correlation between mineral bone metabolism and CRP in patients with SHPT during perioperative period |
| title_short | Study on the correlation between mineral bone metabolism and CRP in patients with SHPT during perioperative period |
| title_sort | study on the correlation between mineral bone metabolism and crp in patients with shpt during perioperative period |
| topic | chronic kidney disease inflammation mineral bone metabolism disorders parathyroidectomy secondary hyperparathyroidism |
| url | https://doi.org/10.1002/iid3.828 |
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