Differential response to topical lubrication in patient with dry eye disease, based on age
Abstract Background To compare the Ocular surface disease index (OSDI) score, Schirmer I test (SIT), fluorescein break up time (FBUT) and fluorescence staining (FLCS) score of dry eye patients at different ages. Methods 90 eyes of 90 patients with mild to moderate dry eye from September 2020 to Sept...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-022-02609-2 |
| _version_ | 1828339542740959232 |
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| author | Yingxin Chen Yajun Wu Minghong Gao Ruiyao Gao Kai Zhang |
| author_facet | Yingxin Chen Yajun Wu Minghong Gao Ruiyao Gao Kai Zhang |
| author_sort | Yingxin Chen |
| collection | DOAJ |
| description | Abstract Background To compare the Ocular surface disease index (OSDI) score, Schirmer I test (SIT), fluorescein break up time (FBUT) and fluorescence staining (FLCS) score of dry eye patients at different ages. Methods 90 eyes of 90 patients with mild to moderate dry eye from September 2020 to September 2021 were retrospectively included and were divided into young group (20–39 years, n = 29), middle-age group (40–59 years, n = 30), and elder group (> 60 years, n = 31). Patients were given a 28-day topical lubricating ocular surface and repair-promoting drugs combined with local physical therapy. Patients were followed up at 7, 14 and 28 days. The OSDI score, SIT, FBUT and FLCS score were examined. Results There were differences between the OSDI score in three groups at each time point (all P < 0.001). SIT were different among the three groups (F = 350.61, P < 0.001), and a time effect was found (F = 80.87, P < 0.001). SIT at 14 and 28 days after treatment in middle-age and elder groups were lower than young group (all P < 0.001). SIT at 7, 14 and 28 days in elder group were lower than middle-age group (all P < 0.001). FLCS score was lower at 28 days than other time points (all P < 0.001). Conclusion Dry eye patients are given a 28-day topical lubricating ocular surface and repair-promoting drugs combined with local physical therapy, which can promote tear secretion, film stability, and the recovery of corneal integrity. Age affects the treatment effect of mild to moderate dry eye, among which tear secretion is the most significant. |
| first_indexed | 2024-04-13T22:44:15Z |
| format | Article |
| id | doaj.art-008ed0983023498eb31a914edf5596e5 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-13T22:44:15Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-008ed0983023498eb31a914edf5596e52022-12-22T02:26:28ZengBMCBMC Ophthalmology1471-24152022-10-012211610.1186/s12886-022-02609-2Differential response to topical lubrication in patient with dry eye disease, based on ageYingxin Chen0Yajun Wu1Minghong Gao2Ruiyao Gao3Kai Zhang4Department of ophthalmology, the General Hospital of Northern Theater CommandDepartment of ophthalmology, the General Hospital of Northern Theater CommandDepartment of ophthalmology, the General Hospital of Northern Theater CommandDepartment of ophthalmology, the General Hospital of Northern Theater CommandDepartment of ophthalmology, the General Hospital of Northern Theater CommandAbstract Background To compare the Ocular surface disease index (OSDI) score, Schirmer I test (SIT), fluorescein break up time (FBUT) and fluorescence staining (FLCS) score of dry eye patients at different ages. Methods 90 eyes of 90 patients with mild to moderate dry eye from September 2020 to September 2021 were retrospectively included and were divided into young group (20–39 years, n = 29), middle-age group (40–59 years, n = 30), and elder group (> 60 years, n = 31). Patients were given a 28-day topical lubricating ocular surface and repair-promoting drugs combined with local physical therapy. Patients were followed up at 7, 14 and 28 days. The OSDI score, SIT, FBUT and FLCS score were examined. Results There were differences between the OSDI score in three groups at each time point (all P < 0.001). SIT were different among the three groups (F = 350.61, P < 0.001), and a time effect was found (F = 80.87, P < 0.001). SIT at 14 and 28 days after treatment in middle-age and elder groups were lower than young group (all P < 0.001). SIT at 7, 14 and 28 days in elder group were lower than middle-age group (all P < 0.001). FLCS score was lower at 28 days than other time points (all P < 0.001). Conclusion Dry eye patients are given a 28-day topical lubricating ocular surface and repair-promoting drugs combined with local physical therapy, which can promote tear secretion, film stability, and the recovery of corneal integrity. Age affects the treatment effect of mild to moderate dry eye, among which tear secretion is the most significant.https://doi.org/10.1186/s12886-022-02609-2Dry eyeAgeOcular surface disease index scoreSchirmer I testFluorescein break up timeCorneal fluorescence staining score |
| spellingShingle | Yingxin Chen Yajun Wu Minghong Gao Ruiyao Gao Kai Zhang Differential response to topical lubrication in patient with dry eye disease, based on age BMC Ophthalmology Dry eye Age Ocular surface disease index score Schirmer I test Fluorescein break up time Corneal fluorescence staining score |
| title | Differential response to topical lubrication in patient with dry eye disease, based on age |
| title_full | Differential response to topical lubrication in patient with dry eye disease, based on age |
| title_fullStr | Differential response to topical lubrication in patient with dry eye disease, based on age |
| title_full_unstemmed | Differential response to topical lubrication in patient with dry eye disease, based on age |
| title_short | Differential response to topical lubrication in patient with dry eye disease, based on age |
| title_sort | differential response to topical lubrication in patient with dry eye disease based on age |
| topic | Dry eye Age Ocular surface disease index score Schirmer I test Fluorescein break up time Corneal fluorescence staining score |
| url | https://doi.org/10.1186/s12886-022-02609-2 |
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